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  • 1
    Online Resource
    Online Resource
    EDP Sciences ; 2021
    In:  E3S Web of Conferences Vol. 245 ( 2021), p. 03089-
    In: E3S Web of Conferences, EDP Sciences, Vol. 245 ( 2021), p. 03089-
    Abstract: Objective: Studying new carrier materials to solve the problems of bioavailability and side effects of drugs in the body and choose the suitable carrier to coat the drug. This carrier not only improves the release and absorption of drug molecules in the body, but also significantly improves the bioavailability and reduces the toxic side effects of high concentrated drugs. Therefore, this paper focuses on the research of the synthesis of a new carrier material. Methods: Using ferric nitrate as iron source, first add ferric nitrate, 1,3,5-benzene tricarbonic acid, chitosan solution and deionized water pro rata, then synthesize the product using mechanical stirring, and purify and dry the product. Results: The maximum yield of chitosan is obtained when the concentration of chitosan is 1% using mechanical stirring method, and the yield is 0.6330 g. Conclusion: The results show that the thinner the concentration of chitosan solution is, the better synthesizes the chitosan@MIL-100(Fe) and the higher the yield is. And it reaches the best result when the concentration is 1%.
    Type of Medium: Online Resource
    ISSN: 2267-1242
    Language: English
    Publisher: EDP Sciences
    Publication Date: 2021
    detail.hit.zdb_id: 2755680-3
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  • 2
    Online Resource
    Online Resource
    EDP Sciences ; 2021
    In:  E3S Web of Conferences Vol. 251 ( 2021), p. 02058-
    In: E3S Web of Conferences, EDP Sciences, Vol. 251 ( 2021), p. 02058-
    Abstract: The aqueous enzymatic method was applied to extract the common pistache oil and the optimal extraction process conditions were identified. By observing the effect of enzymatic hydrolysis time, pH value, temperature on aqueous enzymatic extraction process and performing the orthogonal experiment based on the single factor test, the optimal process parameters were obtained, namely, the optimal time, temperature, and pH value were respectively 3 h, 50℃, and 7 with a final extraction rate of 25.38 %.
    Type of Medium: Online Resource
    ISSN: 2267-1242
    Language: English
    Publisher: EDP Sciences
    Publication Date: 2021
    detail.hit.zdb_id: 2755680-3
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  • 3
    Online Resource
    Online Resource
    IOP Publishing ; 2017
    In:  IOP Conference Series: Earth and Environmental Science Vol. 69 ( 2017-06), p. 012110-
    In: IOP Conference Series: Earth and Environmental Science, IOP Publishing, Vol. 69 ( 2017-06), p. 012110-
    Type of Medium: Online Resource
    ISSN: 1755-1307 , 1755-1315
    Language: Unknown
    Publisher: IOP Publishing
    Publication Date: 2017
    detail.hit.zdb_id: 2434538-6
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  • 4
    Online Resource
    Online Resource
    IOP Publishing ; 2019
    In:  IOP Conference Series: Earth and Environmental Science Vol. 330, No. 4 ( 2019-10-01), p. 042057-
    In: IOP Conference Series: Earth and Environmental Science, IOP Publishing, Vol. 330, No. 4 ( 2019-10-01), p. 042057-
    Abstract: Response surface methodology (RSM) was used to optimize the extraction process of quercetin from pear meal and to investigate its antioxidant capacity. The solvent ratio, ultrasonic power and extraction time were taken as independent variables, and the percentage of quercetin was taken as dependent variable. Through multiple linear regression and binomial fitting of each level of independent variable, the better extraction process was selected by response surface methodology and predicted and analyzed. The antioxidant activity of quercetin was evaluated by scavenging 1.1-diphenylpicrylphenylhydrazine free radical (DPPH.) and reducing ability of iron ions (FRAP). The optimum extraction process was obtained as follows: the ratio of liquid to material was 35 mL/g, the ultrasonic power was 550 W, and the extraction time was 30 min. The content of quercetin was 1.585%. Quercetin in avocado meal has strong DPPH scavenging and iron ion reduction ability. When the concentration is 30 mg/mL, DPPH scavenging rate reaches 70%, and iron ion reduction ability almost equals 6 mmol/L FeSO4 concentration, and has a dose-effect relationship.
    Type of Medium: Online Resource
    ISSN: 1755-1307 , 1755-1315
    Language: Unknown
    Publisher: IOP Publishing
    Publication Date: 2019
    detail.hit.zdb_id: 2434538-6
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  • 5
    Online Resource
    Online Resource
    Bentham Science Publishers Ltd. ; 2021
    In:  Current Organic Synthesis Vol. 18, No. 6 ( 2021-09), p. 587-591
    In: Current Organic Synthesis, Bentham Science Publishers Ltd., Vol. 18, No. 6 ( 2021-09), p. 587-591
    Abstract: Paclitaxel, a natural diterpenoid compound, has anti-tumor effect by acting on tubulin, whereas coumarin, another kind of natural product, has anti-tumor effect, along with some other effects, such as anti-bacterial-., Moreover, it also possesses fluorescence. Objective: Multi targeting is an effective strategy in drug design to combat tumor. Therefore, a combination of paclitaxel with other active molecular drugs for exploring the novel lead with multi-functions is in demand. Materials and Methods: To synthsize paclitaxel-coumarin conjugate via click chemistry and to investigate anticancer activity by MTT assay and the scratch test. Results and Discussion: The results of MTT assay showed that compared tothe paclitaxel, the anti-tumor activity of the conjugate was significantly improved. The results of flow cytometry showed that the conjugate had a stronger ability to induce apoptosis. The scratch test results showed that the conjugate had better anti- metastasis ability than paclitaxel. Conclusion: These findings indicated that paclitaxel and coumarin had a synergistic effect, which paved the way for the development of paclitaxel through fluorescence.
    Type of Medium: Online Resource
    ISSN: 1570-1794
    Language: English
    Publisher: Bentham Science Publishers Ltd.
    Publication Date: 2021
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  • 6
    Online Resource
    Online Resource
    Informa UK Limited ; 2005
    In:  Instrumentation Science & Technology Vol. 33, No. 3 ( 2005-05), p. 339-354
    In: Instrumentation Science & Technology, Informa UK Limited, Vol. 33, No. 3 ( 2005-05), p. 339-354
    Type of Medium: Online Resource
    ISSN: 1073-9149 , 1525-6030
    Language: English
    Publisher: Informa UK Limited
    Publication Date: 2005
    detail.hit.zdb_id: 2020639-2
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  • 7
    Online Resource
    Online Resource
    EDP Sciences ; 2020
    In:  E3S Web of Conferences Vol. 213 ( 2020), p. 01001-
    In: E3S Web of Conferences, EDP Sciences, Vol. 213 ( 2020), p. 01001-
    Abstract: Objective: To explore the effect of culture medium made of peptide fragments of different sizes of globin hydrolyzed by protease on the culture of Escherichia coli. Method: with fresh pig blood as raw material, hydrolyze pig blood protein under fixed conditions, and screen out the enzyme with the highest degree of hydrolysis. Then conduct orthogonal test on the enzyme to determine the best hydrolysis conditions; the beads were obtained under the best hydrolysis conditions. The Escherichia coli was cultured on different peptone culture bases that were prepared by hydrolysate going through different pore size ultrafiltration membrane samples. The culture of Escherichia coli at different hydrolysis depths is determined by detecting the total amount with Escherichia coli detection method. Results: Trypsin has the best hydrolysis effect. The best hydrolysis conditions are as follows: enzyme dosage of 0.2%, hydrolysis time of 12h, temperature of 50°C, initial pH of 7.5 and mass fraction of substrate protein of 8%. Through growth curves of Escherichia coli, it is known that the smaller the pore size of the ultrafiltration membrane, the smaller the molecular weight of the peptide fragment, and the greater the density of the Escherichia coli bacterial solution. Conclusion: Through analyzing the production curves of Escherichia coli in different culture medium, it is concluded that the smaller the molecular weight of the protein peptides, the higher the density of Escherichia coli solution in the LB liquid medium prepared by it, and the better the Escherichia coli culture effect.
    Type of Medium: Online Resource
    ISSN: 2267-1242
    Language: English
    Publisher: EDP Sciences
    Publication Date: 2020
    detail.hit.zdb_id: 2755680-3
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  • 8
    Online Resource
    Online Resource
    IOP Publishing ; 2020
    In:  IOP Conference Series: Earth and Environmental Science Vol. 565 ( 2020-10-01), p. 012053-
    In: IOP Conference Series: Earth and Environmental Science, IOP Publishing, Vol. 565 ( 2020-10-01), p. 012053-
    Type of Medium: Online Resource
    ISSN: 1755-1315
    Language: Unknown
    Publisher: IOP Publishing
    Publication Date: 2020
    detail.hit.zdb_id: 2434538-6
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  • 9
    In: Processes, MDPI AG, Vol. 10, No. 10 ( 2022-10-01), p. 1988-
    Abstract: To study the mechanism of galangal in the treatment of gastric cancer by network pharmacology. The TCMSP database was used to collect the effective compounds and potential targets of galangal, and the genes associated with gastric cancer were obtained through the GeneCards database, and Venn obtained the interaction genes of the effective compound targets of galangal and gastric cancer targets, plotted the interaction genes into PPI networks, and screened out key targets. The interacting genes were imported into Metascape database for GO enrichment analysis and KEGG signal enrichment. A total of 13 active compounds and 207 potential downstream target genes were screened by TCMSP database. Have 5222 gastric cancer target genes through GeneCards database, there were a total of 150 interactive genes and 6 key genes: TP53, AKT1, JUN, HSP90AA1, IL6, and CASP3. These interacting genes involved 30 typical GO entries and 20 KEGG signals. Galangal may play a role in the treatment of gastric cancer by means of multi-component, multi-target and multi-signal pathway.
    Type of Medium: Online Resource
    ISSN: 2227-9717
    Language: English
    Publisher: MDPI AG
    Publication Date: 2022
    detail.hit.zdb_id: 2720994-5
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  • 10
    Online Resource
    Online Resource
    EDP Sciences ; 2021
    In:  E3S Web of Conferences Vol. 251 ( 2021), p. 02052-
    In: E3S Web of Conferences, EDP Sciences, Vol. 251 ( 2021), p. 02052-
    Abstract: Using pitaya as raw material, this paper used ethanol subsiding method to study the extraction technology of pitaya polysaccharide by single factor test and orthogonal test. Through orthogonal test, we have found the optimum extraction conditions of pitaya polysaccharide as follows: extraction temperature 60℃, solid-liquid ratio 1:30, extraction time 3h. Under the optimal extraction conditions, the yield of pitaya polysaccharide was 1.13%.
    Type of Medium: Online Resource
    ISSN: 2267-1242
    Language: English
    Publisher: EDP Sciences
    Publication Date: 2021
    detail.hit.zdb_id: 2755680-3
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