In:
International Journal of Cancer, Wiley, Vol. 147, No. 8 ( 2020-10-15), p. 2065-2074
Abstract:
What's new? Early‐onset pancreatic cancer (EOPC), diagnosed between ages 45 and 60, accounts for about one‐fifth of all pancreatic cancers. Nonetheless, while multiple epidemiological risk factors for EOPC have been identified, very little is known about genetic susceptibility. The present genome‐wide association study identifies four novel single nucleotide polymorphisms specific for patients diagnosed with pancreatic cancer at younger ages. Among the variants, 13q22.3_rs2328991 was associated with elevated risk in an independent set of pancreatic cancer patients, some of whom experienced disease onset at age 50 or younger. The findings highlight a need for further research on the genetics of EOPC.
Type of Medium:
Online Resource
ISSN:
0020-7136
,
1097-0215
Language:
English
Publisher:
Wiley
Publication Date:
2020
detail.hit.zdb_id:
218257-9
detail.hit.zdb_id:
1474822-8
Permalink