GLORIA

GEOMAR Library Ocean Research Information Access

X

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
Filter
Material
Publisher
Person/Organisation
Language
Years
FID
Subjects(RVK)
  • 1
    Online Resource
    Online Resource
    Assessment of the Herd Immunity to SARS-CoV-2 among the Population of the Leningrad Region during the COVID-19 Epidemic
    Russian Research Anti-Plague Institute Microbe ; 2020
    In:  Problems of Particularly Dangerous Infections , No. 3 ( 2020-10-22), p. 114-123
    Details
    In: Problems of Particularly Dangerous Infections, Russian Research Anti-Plague Institute Microbe, , No. 3 ( 2020-10-22), p. 114-123
    Abstract: The first case of COVID-19 was registered in the Leningrad Region on March 13, 2020. The period of increasing intensity of the epidemic process lasted 8 weeks. One month after reaching the maximum incidence rate, a study was organized to determine seroprevalence to COVID-19 among the population of the Region. Objective of the study was to determine the level and structure of community immunity to SARS-CoV-2 virus in the population of the Leningrad Region in the period of intensive COVID-19 transmission. Materials and methods . The work was carried out within the framework of the Rospotrebnadzor project on assessment of community immunity to the SARS-CoV-2 virus in the population of the Russian Federation. The content of antibodies to SARS-CoV-2 was determined applying ELISA using a kit for the analysis of human serum or blood plasma for the presence of specific IgG to the nucleocapsid of the SARS-CoV-2 virus , manufactured by the State Scientific Center of Applied Microbiology and Biotechnology (Obolensk) in accordance with the instructions for use. Results and discussion . The study has showed that the herd immunity of the population of the Leningrad Region was 20.7 %. The maximum level has been established in children 1–6 years old (42.3 %) and people over 70 years old (29.0 %). The highest level of seropositivity, except for children and older people, was found among the unemployed (25.1 %). The lowest level of seroprevalence was detected in civil servants (12.8 %) and military personnel (16.7 %). It has been shown that the risk of infection increases by 1.5 times in case of contacts with COVID-19 patients. After exposure to COVID-19 virus, antibodies are produced in 82.1 % of the cases. In individuals with a positive PCR test result obtained earlier, antibodies are detected in 82.8 % of cases. The share of asymptomatic forms among seropositive residents of the Leningrad Region was 86.9 %. The results of assessing the herd immunity to SARS-CoV-2 in the population of the Leningrad Region indicate that during the period of intensive COVID-19 transmission, an average level of seroprevalence was formed. A significant proportion of asymptomatic forms of infection characterizes the high intensity of the latently developing epidemic process. The results obtained should be taken into account when organizing preventive measures, including vaccination, and predicting morbidity rates. 
    Type of Medium: Online Resource
    ISSN: 2658-719X , 0370-1069
    URL: Article
    DOI: 10.21055/0370-1069-2020-3-114-123
    Language: Unknown
    Publisher: Russian Research Anti-Plague Institute Microbe
    Publication Date: 2020
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 2
    Online Resource
    Online Resource
    Evaluation of the main regulators of extracellular matrix metabolism in healthy adolescents in the Far North
    The National Academy of Pediatric Science and Innovation ; 2023
    In:  Rossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics) Vol. 68, No. 1 ( 2023-03-02), p. 117-122
    Details
    In: Rossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics), The National Academy of Pediatric Science and Innovation, Vol. 68, No. 1 ( 2023-03-02), p. 117-122
    Abstract: Myocardial remodeling is well-known to be both an adaptive option under certain conditions of life (sports, pregnancy, etc.), and the result of cardiovascular pathology. The study of the features of cardiac remodeling includes the involvement of cardiomyocytes in the process by the level of troponins, creatine phosphokinase, and its cardiac isoform as markers of ischemia and necrosis. Also, neurohormonal rearrangement is evaluated using a natriuretic peptide, and endothelial dysfunction is determined using a C–reactive protein. The level of matrix metalloproteinases (MMP) and their tissue inhibitors (TIMP) reflects the degree of the proteolytic activity and collagen fibers’ degradation. However, there are no clear biochemical markers of “adaptive heart” and pathological changes in different age periods, in the climatic environment, various types and severity of sports loads, especially when evaluating matrix metalloproteinases and their tissue inhibitors. The primary task in determining the criteria for pathological remodeling of the myocardium becomes the definition of normative indicators.The aim of the study was to determine the reference values of the main biochemical markers of cardiac remodeling in healthy adolescents living in the Far North. The levels of troponin I, creatine phosphokinase-MV, aspartate aminotransferase did not exceed the generally accepted standard values. There were correlations between lactate dehydrogenase, aspartate aminotransferase, and mass-growth indicators of adolescents. Markers of extracellular matrix degradation (MMP-9, TIMP-1 and TIMP-4, MMP-9/ TIMP-1) differed from the data available in the published studies, which is probably due to the influence of tissue hypoxia associated with the climatic living conditions and the age in children of the study group.
    Type of Medium: Online Resource
    ISSN: 2500-2228 , 1027-4065
    URL: Article
    DOI: 10.21508/1027-4065-2023-68-1-117-122
    Language: Unknown
    Publisher: The National Academy of Pediatric Science and Innovation
    Publication Date: 2023
    detail.hit.zdb_id: 2953971-7
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 3
    Online Resource
    Online Resource
    ChemInform Abstract: Synthesis of Binuclear Ge-Substituted 1,4-Bis(dimethylgermylmethyl)-2, 5-piperazinediones.
    Wiley ; 2010
    In:  ChemInform Vol. 22, No. 35 ( 2010-08-22), p. no-no
    Details
    In: ChemInform, Wiley, Vol. 22, No. 35 ( 2010-08-22), p. no-no
    Type of Medium: Online Resource
    ISSN: 0931-7597
    URL: Article
    DOI: 10.1002/chin.199135217
    Language: English
    Publisher: Wiley
    Publication Date: 2010
    detail.hit.zdb_id: 2110203-X
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 4
    Online Resource
    Online Resource
    Estimation of erythrocyte parameters of general blood analysis in patients with SARS-CoV-2 -associated pneumonia
    EKOlab ; 2022
    In:  Russian Clinical Laboratory Diagnostics Vol. 67, No. 1 ( 2022-01-21), p. 24-30
    Details
    In: Russian Clinical Laboratory Diagnostics, EKOlab, Vol. 67, No. 1 ( 2022-01-21), p. 24-30
    Abstract: The study of the features and dynamics of the erythrocyte parameters of general blood analysis in patients with cardiovascular diseases who underwent SARS-CoV-2 associated pneumonia is of great practical importance. That was a prospective study. The study included 106 patients with SARS-CoV-2-associated pneumonia. All patients were divided into 2 groups. The first group included 51 patients without CVD, the second group included 55 patients with CVD .Patients in both groups underwent laboratory examination of blood samples at the time of hospitalization and 3 months after discharge from the hospital. Parameters of the erythroid series of the general blood test were assessed. Among inflammatory biomarkers, we examined the concentration of C-reactive protein (CRP), high-sensitivity CRP (hs-CRP) and homocysteine. Initially all patients underwent computed tomography of the chest organs. Revealed what indicators of the erythroid series in the groups of patients with and without CVD had significant differences in a number of parameters: ESR; RDW-SD and RDW-CV with significant excess of parameters in group 2. Three months after discharge from the hospital, patients in both groups had a significant increase in HCT, MCV, MCH. There was detected decrease in both groups in MCHC, RDW-CV (p 〈 0.001 for all parameters), ESR level in group 2.At baseline, CRP exceeded reference values in both groups of patients, reaching maximum values in group 2. After 3 months CRP decreased significantly only in group 1. Increased CRP was associated with elevated hs-CRP in 3 months after discharge and elevated homocysteine levels in both groups, indicating the persistence of prolonged inflammatory vascular reaction in patients after SARS-CoV-2 associated pneumonia, more pronounced in group 2 patients. RDW-CV over 13.6 and lymphocytes / CRP less than 0.6 increase the likelihood of having lung tissue damage over 50% by 9.3 and 5.9 times, respectively. Thus, the data obtained confirm that RDW-CV, the coefficient of variation of erythrocyte distribution width, associated with the parameters of inflammatory response and the lymphocytes / CRP is lung volume marker and of COVID-19 severity. Careful consideration of already known laboratory parameters allows us to expand the number of indicators influencing the risk of COVID-19 complications and enable an earlier response to a difficult situation.
    Type of Medium: Online Resource
    ISSN: 2412-1320 , 0869-2084
    URL: Issue
    URL: Article
    DOI: 10.51620/0869-2084-2022-67-1
    DOI: 10.51620/0869-2084-2022-67-1-24-30
    Language: Unknown
    Publisher: EKOlab
    Publication Date: 2022
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 5
    Online Resource
    Online Resource
    Equilibrium constants of the intermolecular interaction of barbiturates with dihalonitrophenols and their relationship to physiological activity
    Springer Science and Business Media LLC ; 1982
    In:  Pharmaceutical Chemistry Journal Vol. 16, No. 3 ( 1982-03), p. 172-174
    Details
    In: Pharmaceutical Chemistry Journal, Springer Science and Business Media LLC, Vol. 16, No. 3 ( 1982-03), p. 172-174
    Type of Medium: Online Resource
    ISSN: 0091-150X , 1573-9031
    URL: Article
    DOI: 10.1007/BF00777262
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 1982
    detail.hit.zdb_id: 2039418-4
    SSG: 15,3
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 6
    Online Resource
    Online Resource
    Changes in the content and structure of the liver coenzyme a reserves in diabetic (db/db) mice during nicotinamide therapy
    Springer Science and Business Media LLC ; 1987
    In:  Bulletin of Experimental Biology and Medicine Vol. 103, No. 5 ( 1987-5), p. 634-636
    Details
    In: Bulletin of Experimental Biology and Medicine, Springer Science and Business Media LLC, Vol. 103, No. 5 ( 1987-5), p. 634-636
    Type of Medium: Online Resource
    ISSN: 0007-4888 , 1573-8221
    URL: Article
    DOI: 10.1007/BF00841821
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 1987
    detail.hit.zdb_id: 2037110-X
    SSG: 12
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 7
    Online Resource
    Online Resource
    Growth differentiation factor 15 as an integral marker of the clinical and functional status of patients with non-valvular atrial fibrillation
    Institute of Cardio Technics - INCART ; 2021
    In:  Journal of Arrhythmology Vol. 28 ( 2021-10-26), p. 32-38
    Details
    In: Journal of Arrhythmology, Institute of Cardio Technics - INCART, Vol. 28 ( 2021-10-26), p. 32-38
    Abstract: Aim.  To study the relationship between growth differentiation factor 15 (GDF-15) level in blood serum and patient clinical and functional status parameters, and to determine predictors of GDF-15 level in pts with non-valvular atrial fibrillation (AF). Material and methods.  Eighty-seven pts (with the mean age of 56.9±9.2 years) with non-valvular AF were studied. A general clinical examination, as well as echocardiography and laboratory tests were performed. These included fasting serum glucose (mmol/l), highly sensitive C-reactive protein (h/s CRP) (mg/l), creatinine level (μmol/l) and subsequent calculation of glomerular filtration rate (ml/min/1.73m2), and N-terminal pro-B-type natriuretic peptide (NT-proBNP) (pg/ml). The level of GDF-15 (pg/ml) in blood serum was determined using an enzyme immunoassay with a human ELISA analytical kit. Results.  An increase in GDF-15 level was associated with age, ischemic heart disease, severity of hypertension, and heart failure, resulting in a higher risk of stroke, according to the CHA2DS2 -VASc score, carbohydrate metabolism disorders and obesity, increased h/s CRP and NT-proBNP levels, enlargement of the right and left atria, signs of diastolic left ventricular dysfunction and structural remodeling in the form of eccentric hypertrophy. Multiple linear regression analysis revealed 2 independent predictors of GDF-15 levels: age and fasting glucose. Conclusion.  GDF-15 is an integral biomarker of age-related metabolic disorders and structural and functional changes in the heart, which opens up prospects for further study of its prognostic significance in pts with non-valvular AF.
    Type of Medium: Online Resource
    ISSN: 2658-7327 , 1561-8641
    URL: Article
    DOI: 10.35336/VA-2021-E-32-38
    Language: Unknown
    Publisher: Institute of Cardio Technics - INCART
    Publication Date: 2021
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 8
    Online Resource
    Online Resource
    Intensification of ethyl alcohol technology due to multienzyme composition
    IOP Publishing ; 2022
    In:  IOP Conference Series: Earth and Environmental Science Vol. 1052, No. 1 ( 2022-07-01), p. 012111-
    Details
    In: IOP Conference Series: Earth and Environmental Science, IOP Publishing, Vol. 1052, No. 1 ( 2022-07-01), p. 012111-
    Abstract: The effect of the complex enzyme preparation Bruzaym BGX on the viscosity of rye kneading was studied. The dynamics of glucose accumulation in the wort is shown, as well as the possibility of reducing the dosage of glucoamylase when using a multi-enzyme complex at the stage of water-heat treatment. The effect of the enzyme complex on the fermentation kinetics of rye wort was studied. It was found that the use of a multienzyme complex at the stage of water-heat treatment allows one to increase the glucose content in the wort by 34.7 %, compared with the control. This increases the yield of alcohol by 1.4 decalitres/t of conditional starch, reduces the duration of fermentation to 50 – 52 hours and reduces the total content of impurities in the mature brew by 10%.
    Type of Medium: Online Resource
    ISSN: 1755-1307 , 1755-1315
    URL: Article
    DOI: 10.1088/1755-1315/1052/1/012111
    Language: Unknown
    Publisher: IOP Publishing
    Publication Date: 2022
    detail.hit.zdb_id: 2434538-6
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 9
    Online Resource
    Online Resource
    Age of the Sources of Metaterrigenous Rocks in the Leshchev Zone (Southern Part of the Middle Volga Megablock of the Volgo–Uralian Segment of the East European Craton)
    Pleiades Publishing Ltd ; 2022
    In:  Doklady Earth Sciences Vol. 507, No. S2 ( 2022-12), p. S231-S239
    Details
    In: Doklady Earth Sciences, Pleiades Publishing Ltd, Vol. 507, No. S2 ( 2022-12), p. S231-S239
    Type of Medium: Online Resource
    ISSN: 1028-334X , 1531-8354
    URL: Article
    DOI: 10.1134/S1028334X22601079
    Language: English
    Publisher: Pleiades Publishing Ltd
    Publication Date: 2022
    detail.hit.zdb_id: 2227421-2
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 10
    Online Resource
    Online Resource
    Features of arterial hypertension in postmenopausal women with abdominal obesity: The role of inflammatory response markers, leptin, and female sex hormones in the pathogenesis of vascular wall stiffness
    Cardiology Research Institute ; 2019
    In:  The Siberian Medical Journal Vol. 34, No. 3 ( 2019-11-04), p. 103-113
    Details
    In: The Siberian Medical Journal, Cardiology Research Institute, Vol. 34, No. 3 ( 2019-11-04), p. 103-113
    Abstract: Background . Despite overall efforts, arterial hypertension remains one of the most significant medical and social problems. The risk of developing arterial hypertension is tripled in obese individuals compared with people who have normal body weight. According to clinical studies, individual biochemical markers can be predictors of initiation of remodeling processes in systems at a preclinical level. Endothelial dysfunction is the initial stage in the development of atherosclerosis. Mechanisms of the vascular inflammatory response in arterial hypertension with obesity can be considered a factor that largely determines the onset and course of the disease, a cause of its aggravation, development, and progression. Cardiovascular risk factors, genetic predisposition, deficit of sex hormones, and aging affect the endothelium function. Aim . To study specifics of hypertension in postmenopausal women with abdominal obesity and to evaluate the role of inflammatory response markers, leptin, and female sex hormones in the pathogenesis of vascular wall stiffness. Material and Methods . The study included 164 patients divided into three groups. Group 1 consisted of 42 healthy women aged 44.43 ± 14.26 years; group 2 comprised 62 hypertensive women aged 60.69 ± 7.09 years; group 3 comprised 60 hypertensive women with abdominal obesity aged 57.24 ± 7.40 years. Patients of all groups received 24-hour blood pressure monitoring, sphygmography, and assessment of sex hormones, lipids, inflammatory, and biochemical parameters in blood serum. Results . Results of analysis showed that patients of group 3 had significantly higher blood pressure compared with that in group 2. Higher pulse wave velocity was observed in women of group 2. Groups 2 and 3 had lower levels of sex hormones and significant increases in the levels of inflammatory markers compared with those in control group. Multiple multidirectional correlations between the studied parameters were revealed. Conclusions . Features of hypertension in postmenopausal women with obesity consist in a systolic-diastolic variant of hypertension, an increase in systolic blood pressure variability at night, an increase in diastolic blood pressure during the daytime, and increases in systolic and diastolic blood pressure at night. The method of logistic regression allowed to identify biochemical markers that determine the elastic properties of the vascular wall in this category of patients, namely: leptin, highsensitivity C-reactive protein, and endothelin-1. 
    Type of Medium: Online Resource
    ISSN: 2073-8552
    URL: Issue
    URL: Article
    DOI: 10.29001/2073-8552-2019-34-3
    DOI: 10.29001/2073-8552-2019-34-3-103-113
    Language: Unknown
    Publisher: Cardiology Research Institute
    Publication Date: 2019
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...