In:
Molecular Cancer Therapeutics, American Association for Cancer Research (AACR), Vol. 10, No. 11_Supplement ( 2011-11-12), p. C134-C134
Abstract:
We have recently demonstrated the feasibility of using targeted, polymer-based siRNA nanoparticles in the clinic1. This delivery system involved the use of the human protein transferrin (Tf) that is displayed on the surface of the nanoparticles to engage cancer cell surface, transferrin receptors (TfR). Here, we demonstrate the modular nature of this siRNA delivery system by tailoring both the targeting agent and siRNA component of the nanoparticle to Her2 positive breast cancers. Specifically, we show that the siRNA nanoparticle delivery system can be modified to include an antibody targeting agent (Herceptin) without any significant alteration to size, charge, and pharmacokinetic behavior. We also show that in vivo treatment of Her2 positive breast cancer tumor xenografts with Herceptin-targeted nanoparticles containing siRNA against Her2 results in a more robust anti-tumor response than either Herceptin alone or Herceptin-targeted nanoparticles containing control siRNA. These data demonstrate how nanoparticles containing the combination of antibodies and siRNA can be used to achieve enhanced therapeutic treatment against clinically validated cancer targets. References: 1. Davis, M.E. et al. Evidence of RNAi in humans from systemically administered siRNA via targeted nanoparticles. Nature 464, 1067–1070 (2010). Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the AACR-NCI-EORTC International Conference: Molecular Targets and Cancer Therapeutics; 2011 Nov 12-16; San Francisco, CA. Philadelphia (PA): AACR; Mol Cancer Ther 2011;10(11 Suppl):Abstract nr C134.
Type of Medium:
Online Resource
ISSN:
1535-7163
,
1538-8514
DOI:
10.1158/1535-7163.TARG-11-C134
Language:
English
Publisher:
American Association for Cancer Research (AACR)
Publication Date:
2011
detail.hit.zdb_id:
2062135-8
SSG:
12
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