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  • 1
    Online Resource
    Online Resource
    Optimize quantum simulation using a force-gradient integrator
    IOP Publishing ; 2021
    In:  EPL (Europhysics Letters) Vol. 135, No. 1 ( 2021-07-01), p. 10004-
    Details
    In: EPL (Europhysics Letters), IOP Publishing, Vol. 135, No. 1 ( 2021-07-01), p. 10004-
    Type of Medium: Online Resource
    ISSN: 0295-5075 , 1286-4854
    URL: Article
    DOI: 10.1209/0295-5075/135/10004
    Language: Unknown
    Publisher: IOP Publishing
    Publication Date: 2021
    detail.hit.zdb_id: 1465366-7
    detail.hit.zdb_id: 165776-8
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  • 2
    Online Resource
    Online Resource
    Simultaneous Determination of Phenolic Acids, Anthraquinones, and Flavonoids in the Aerial Part and the Fruit of Xanthium Sibiricum by LC- ESI- QTRAP-MS/MS
    Bentham Science Publishers Ltd. ; 2019
    In:  Current Pharmaceutical Analysis Vol. 15, No. 5 ( 2019-05-23), p. 542-553
    Details
    In: Current Pharmaceutical Analysis, Bentham Science Publishers Ltd., Vol. 15, No. 5 ( 2019-05-23), p. 542-553
    Abstract: Xanthium sibiricum is a well-known traditional Chinese medicine (TCM) that has been commonly used to treat rhinitis and related nasal diseases. The aim of this study was to develop a comprehensive analytical method based on high-performance liquid chromatographyelectrospray ionization coupled with triple quadrupole-linear ion trap mass spectrometry (LC-ESIQTRAP- MS/MS) for the simultaneous determination of phenolic acids, anthraquinones, and flavonoids in the aerial part and fruit of Xanthium sibiricum. Methods: The separation was completed on Agilent ZORBAX SB-C18 column (250 × 4.6 mm, 5μm) using methanol and 0.2% (v/v) aqueous formic acid as the mobile phase. The target components were analyzed in negative ion mode with accurate and sensitive multiple reaction monitoring (MRM) mode. Results: The correlation coefficients of all the calibration curves were higher than 0.9994. Relative standard deviations of intra- and inter-day precisions of the eighteen components were all lower than 2.87% and the recoveries were in the range from 97.73% to 101.82%. The validated method was successfully applied to possess forty Xanthium sibiricum samples (Xanthii Herba, Xanthii Fructus, and processed Xanthii Fructus) collected from different places in P. R. China. Furthermore, principal component analysis (PCA) was performed to evaluate and classify the samples according to the contents of the eighteen bioactive components. Conclusion: All the results demonstrated that the developed method was useful and could be applied for the overall assessment of the quality of Xanthii Herba and Xanthii Fructus.
    Type of Medium: Online Resource
    ISSN: 1573-4129
    URL: Article
    DOI: 10.2174/1573412914666180502125549
    Language: English
    Publisher: Bentham Science Publishers Ltd.
    Publication Date: 2019
    SSG: 15,3
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  • 3
    Online Resource
    Online Resource
    Silencing MYH9 blocks HBx-induced GSK3β ubiquitination and degradation to inhibit tumor stemness in hepatocellular carcinoma
    Springer Science and Business Media LLC ; 2020
    In:  Signal Transduction and Targeted Therapy Vol. 5, No. 1 ( 2020-02-14)
    Details
    In: Signal Transduction and Targeted Therapy, Springer Science and Business Media LLC, Vol. 5, No. 1 ( 2020-02-14)
    Abstract: MYH9 has dual functions in tumors. However, its role in inducing tumor stemness in hepatocellular carcinoma (HCC) is not yet determined. Here, we found that MYH9 is an effective promoter of tumor stemness that facilitates hepatocellular carcinoma pathogenesis. Importantly, targeting MYH9 remarkably improved the survival of hepatocellular carcinoma-bearing mice and promoted sorafenib sensitivity of hepatocellular carcinoma cells in vivo. Mechanistic analysis suggested that MYH9 interacted with GSK3β and reduced its protein expression by ubiquitin-mediated degradation, which therefore dysregulated the β-catenin destruction complex and induced the downstream tumor stemness phenotype, epithelial–mesenchymal transition, and c-Jun signaling in HCC. C-Jun transcriptionally stimulated MYH9 expression and formed an MYH9/GSK3β/β-catenin/c-Jun feedback loop. X protein is a hepatitis B virus (HBV)-encoded key oncogenic protein that promotes HCC pathogenesis. Interestingly, we observed that HBV X protein (HBX) interacted with MYH9 and induced its expression by modulating GSK3β/β-catenin/c-Jun signaling. Targeting MYH9 blocked HBX-induced GSK3β ubiquitination to activate the β-catenin destruction complex and suppressed cancer stemness and EMT. Based on TCGA database analysis, MYH9 was found to be elevated and conferred poor prognosis for hepatocellular carcinoma patients. In clinical samples, high MYH9 expression levels predicted poor prognosis of hepatocellular carcinoma patients. These findings identify the suppression of MYH9 as an alternative approach for the effective eradication of CSC properties to inhibit cancer migration, invasion, growth, and sorafenib resistance in HCC patients. Our study demonstrated that MYH9 is a crucial therapeutic target in HCC.
    Type of Medium: Online Resource
    ISSN: 2059-3635
    URL: Article
    DOI: 10.1038/s41392-020-0111-4
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2020
    detail.hit.zdb_id: 2886872-9
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  • 4
    Online Resource
    Online Resource
    Sulforaphane suppresses EMT and metastasis in human lung cancer through miR-616-5p-mediated GSK3β/β-catenin signaling pathways
    Springer Science and Business Media LLC ; 2017
    In:  Acta Pharmacologica Sinica Vol. 38, No. 2 ( 2017-2), p. 241-251
    Details
    In: Acta Pharmacologica Sinica, Springer Science and Business Media LLC, Vol. 38, No. 2 ( 2017-2), p. 241-251
    Type of Medium: Online Resource
    ISSN: 1671-4083 , 1745-7254
    URL: Article
    DOI: 10.1038/aps.2016.122
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2017
    detail.hit.zdb_id: 2088565-9
    SSG: 15,3
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  • 5
    Online Resource
    Online Resource
    A new setup to tune the center wavelength of FBGs
    Springer Science and Business Media LLC ; 2005
    In:  Optoelectronics Letters Vol. 1, No. 2 ( 2005-9), p. 107-109
    Details
    In: Optoelectronics Letters, Springer Science and Business Media LLC, Vol. 1, No. 2 ( 2005-9), p. 107-109
    Type of Medium: Online Resource
    ISSN: 1673-1905 , 1993-5013
    URL: Article
    DOI: 10.1007/BF03033679
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2005
    detail.hit.zdb_id: 2375972-0
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  • 6
    Online Resource
    Online Resource
    Investigation of Hot Workability and Microstructure Evolution of VGCNFs-Reinforced Aluminum Matrix Composites
    Springer Science and Business Media LLC ; 2020
    In:  Metallurgical and Materials Transactions A Vol. 51, No. 8 ( 2020-08), p. 4100-4112
    Details
    In: Metallurgical and Materials Transactions A, Springer Science and Business Media LLC, Vol. 51, No. 8 ( 2020-08), p. 4100-4112
    Type of Medium: Online Resource
    ISSN: 1073-5623 , 1543-1940
    URL: Article
    DOI: 10.1007/s11661-020-05834-w
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2020
    detail.hit.zdb_id: 1179415-X
    detail.hit.zdb_id: 2037517-7
    detail.hit.zdb_id: 192156-3
    SSG: 19,1
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  • 7
    Online Resource
    Online Resource
    Dynamic Changes of Eight Bioactive Constituents in Magnoliae Officinalis Cortex Based on UFLC-QTRAP-MS/MS Combined with Grey Relational Analysis
    Bentham Science Publishers Ltd. ; 2019
    In:  Current Pharmaceutical Analysis Vol. 15, No. 5 ( 2019-05-23), p. 497-504
    Details
    In: Current Pharmaceutical Analysis, Bentham Science Publishers Ltd., Vol. 15, No. 5 ( 2019-05-23), p. 497-504
    Abstract: Magnoliae Officinalis Cortex is a well-known traditional Chinese herbal medicine with vast clinical consumption owing to its positive effects. However, little attention has been devoted to analyzing the dynamic changes of the chemical constituents of Magnoliae Officinalis Cortex in different growth periods. Methods: In this study, all analyses were performed on UFLC -20ADXR system and a SynergiTM Hydro-RP 100 Å column (100 mm×2.0 mm, 2.5µm). The mobile phase consisted of water containing 0.1% formic acid (A) and acetonitrile containing 0.1% formic acid (B). The target constituents, including two lignans, two alkaloids, two flavonoids, one phenylpropanoid glycoside, and one organic acid, were analyzed in both positive and negative ion modes with accurate and sensitive multiple reaction monitoring (MRM) mode. Results: The correlation coefficients of all the calibration curves were higher than 0.9992. Relative standard deviations of intra- and inter-day precisions of the eight analytes were all lower than 4.01% and the recoveries were in the range from 98.62% to 102.46%. Grey relational analysis was performed to evaluate the samples according to the contents of 8 constituents. The results showed that the quality of Magnoliae Officinalis Cortex collected at traditional harvest time was much better, and the higher the age, the better the quality. Conclusion: The proposed method is useful for the assessment on the quality of Magnoliae Officinalis Cortex, and this study provides the basis for exploring the quality forming mechanism of Magnoliae Officinalis Cortex medicinal materials and choosing the suitable harvesting period.
    Type of Medium: Online Resource
    ISSN: 1573-4129
    URL: Article
    DOI: 10.2174/1573412914666180903123749
    Language: English
    Publisher: Bentham Science Publishers Ltd.
    Publication Date: 2019
    SSG: 15,3
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  • 8
    Online Resource
    Online Resource
    Studying What Influences the Effects of Environmental Education on Visitors of Fuzhou National Park in China—The Mediating Role of Place Attachment
    MDPI AG ; 2022
    In:  Forests Vol. 13, No. 10 ( 2022-10-20), p. 1735-
    Details
    In: Forests, MDPI AG, Vol. 13, No. 10 ( 2022-10-20), p. 1735-
    Abstract: With the rapid and vigorous growth of forest tourism, the irresponsible environmental behavior of tourists has caused enormous strain on forests’ ecological systems. Carrying out environmental education in forest parks is conducive to promoting the sustainable development of forest tourism. To explore the impact of human–place emotion on environmental education effects, this study took Fuzhou National Forest Park as an example to construct a structural equation model composed of landscape perception, environment interpretation, place attachment, and the effects of environmental education (EEE). The relationship between the four elements and the mechanism of action was clarified. A questionnaire was used with 480 visitors. Statistical analysis showed that: (1) The value of scientific research and education (0.774) influences landscape perception. Reliability (0.770) and tangibility (0.718) contribute to environmental interpretation. Place identification and dependence are represented by environmental identity (0.771) and are activity-dependent (0.792), respectively. Knowledge (0.860) and behavior (0.869) are essential factors in driving the EEE. (2) Place attachment and environment interpretation had a significant positive impact on the environmental education effect (p 〈 0.001), and there was no direct effect between landscape perception and EEE. (3) Landscape perception and environmental interpretation indirectly influence EEE with place attachment as full and partial mediators, respectively. This paper aims to provide theoretical support for better synergistic growth of forest park ecology, economy, and environment.
    Type of Medium: Online Resource
    ISSN: 1999-4907
    URL: Article
    DOI: 10.3390/f13101735
    Language: English
    Publisher: MDPI AG
    Publication Date: 2022
    detail.hit.zdb_id: 2527081-3
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  • 9
    Online Resource
    Online Resource
    Quality Evaluation of Prunellae Spica Based on Simultaneous Determination of Multiple Bioactive Constituents Combined with Grey Relational Analysis
    SAGE Publications ; 2017
    In:  Natural Product Communications Vol. 12, No. 7 ( 2017-07), p. 1934578X1701200-
    Details
    In: Natural Product Communications, SAGE Publications, Vol. 12, No. 7 ( 2017-07), p. 1934578X1701200-
    Abstract: Prunellae Spica (PS) is an important traditional Chinese herbal medicine (TCM) with massive consumption because of its therapeutical and seasoning effects. However, little attention has been paid to simultaneous analyze its bioactive components for quality control of PS based on its different growing habitats and different growth periods. In this study, the quality of PS was evaluated based on simultaneous determination of multiple bioactive components combined with grey relational analysis (GRA). A reliable method based on high-performance liquid chromatography tandem triple quadrupole mass spectrometry (HPLC-QTRAP-MS/MS) was established to simultaneously determine the contents of 21 components in PS, including 9 phenolic acids, 3 coumarins, 8 flavonoids and 1 pentacyclic triterpene. Furthermore, GRA was performed to evaluate the quality of PS samples according to the contents of these 21 components. The results showed that the quality of PS harvested on withering period, cultivated in Anhui was better than that of other PS samples. The proposed method is useful for the overall assessment on the quality of PS, and this study provides valuable information for revealing the dynamic change laws of metabolite accumulation in PS and choosing the most suitable harvesting time and genuine producing area of PS to obtain the best quality.
    Type of Medium: Online Resource
    ISSN: 1934-578X , 1555-9475
    URL: Article
    DOI: 10.1177/1934578X1701200729
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2017
    detail.hit.zdb_id: 2430442-6
    SSG: 15,3
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  • 10
    Online Resource
    Online Resource
    Chemical Differentiation of Pseudostellariae Radix from Different Cultivated Fields and Germplasms by UPLC-Triple TOF-MS/MS Coupled with Multivariate Statistical Analysis
    SAGE Publications ; 2016
    In:  Natural Product Communications Vol. 11, No. 12 ( 2016-12), p. 1934578X1601101-
    Details
    In: Natural Product Communications, SAGE Publications, Vol. 11, No. 12 ( 2016-12), p. 1934578X1601101-
    Abstract: To explore rapidly the potential chemical markers for differentiating Pseudostellariae Radix from different cultivated fields and germplasms, a method is proposed based on ultra-performance liquid chromatography-triple time-of-flight mass/mass spectrometry (UPLC-Triple TOF-MS/MS) coupled with multivariate statistical analysis. Peak matching, peak alignment, and noise filtering were used in analyzing mass spectrometric data. Accurate m/z value analysis of MS data based on software of database search and MS/MS fragment analysis were applied to identify constituents. The obtained data were statistically analyzed with hierarchical cluster analysis (HCA), principal component analysis (PCA), and partial least squared-discriminant analysis (PLS-DA) to compare the differences among these samples. The PLS-DA loading plot obtained from all mass data showed that 21 compounds were identified as the potential chemical markers to characterize the samples. The results provide experimental data to reveal the influence of ecological environments and germplasms on metabolite biosynthesis in Pseudostellariae Radix.
    Type of Medium: Online Resource
    ISSN: 1934-578X , 1555-9475
    URL: Article
    DOI: 10.1177/1934578X1601101214
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2016
    detail.hit.zdb_id: 2430442-6
    SSG: 15,3
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