In:
Journal of Applied Physiology, American Physiological Society, Vol. 15, No. 5 ( 1960-09-01), p. 953-957
Abstract:
Radioiodinated diiodo-p-aminohippuric acid (DI 131 PAH) and N-(2,4-diiodo-3-hydroxyphenyl) urea (DI 131 HPU) were synthesized and examined for their potential usefulness in measuring the cardiac output in animals. These labeled compounds were injected intravenously into rats, rabbits and 13 dogs for study. The average rate of disappearance of DI 131 PAH from the blood stream of dogs was 50% and 90% in 1.0 and 6.9 minutes, respectively. Only a very small percentage of the injected radioactivity localized in the tissues, with approximately 0.5% in the thyroid at 24 hours. Under appropriate conditions of the experiment, more than 90% of the injected radioactivity was recovered in the excreta. Cardiac output values determined with DI 131 PAH on dogs were reproducible and in the range of reported values determined with other materials. Submitted on January 25, 1960
Type of Medium:
Online Resource
ISSN:
8750-7587
,
1522-1601
DOI:
10.1152/jappl.1960.15.5.953
Language:
English
Publisher:
American Physiological Society
Publication Date:
1960
detail.hit.zdb_id:
1404365-8
SSG:
12
SSG:
31
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