In:
APMIS, Wiley, Vol. 125, No. 6 ( 2017-06), p. 511-522
Abstract:
Chronic lymphocytic leukemia ( CLL ) is the most common leukemia in adults. Its clinical course is typically indolent; however, based on a series of pathobiological, clinical, genetic, and phenotypic parameters, patient survival varies from less than 5 to more than 20 years. In this paper, we show for the first time that the expression of the interferon‐inducible DNA sensor IFI 16, a member of the PYHIN protein family involved in proliferation inhibition and apoptosis regulation, is associated with the clinical outcome in CLL . We studied 99 CLL s cases by immunohistochemistry and 10 CLL s cases by gene expression profiling. We found quite variable degrees of IFI 16 expression among CLL s cases. Noteworthy, we observed that a reduced IFI 16 expression was associated with a very poor survival, but only in cases with ZAP 70/ CD 38 expression. Furthermore, we found that IFI 16 expression was associated with a specific gene expression signature. As IFI 16 can be easily detected by immunohistochemistry or flow cytometry, it may become a part of phenotypic screening in CLL patients if its prognostic role is confirmed in independent series.
Type of Medium:
Online Resource
ISSN:
0903-4641
,
1600-0463
DOI:
10.1111/apm.2017.125.issue-6
Language:
English
Publisher:
Wiley
Publication Date:
2017
detail.hit.zdb_id:
2098213-6
SSG:
12
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