In:
Circulation, Ovid Technologies (Wolters Kluwer Health), Vol. 146, No. Suppl_1 ( 2022-11-08)
Abstract:
Introduction: There are more than 250,000 publications on COVID-19. However, there is incomplete information on the effects of pharmacologic therapy in hospitalized patients. Hypothesis: We hypothesize that use of statin therapy will decrease all-cause mortality in patients hospitalized for COVID-19. Methods: A dataset of 1,064 patients with first admission for COVID-19 was used in this study. Predictive models using logistic regression, support-vector machines, and neural networks were used to predict all-cause in-hospital death. Results: In-hospital case fatality of patients admitted with COVID-19 was 17.5% and was higher in the first week after admission, among older individuals, those with higher body weight, and those with longer length of stay. The use of statins was associated with lower in-hospital mortality after adjustment for other medications and the factors mentioned above. The beneficial effect of statins may not be due to their effects on lipids but is probably due to their pleiotropic antioxidant effects. Using logistic regression, the duration of therapy was positively related to the beneficial effect of statins (p=0.0002). Conclusions: In conclusion, the in-hospital case fatality of COVID-19 patients was lower in patients receiving statins after adjustment for demographics, other medications, body weight, and length of stay (Figure).
Type of Medium:
Online Resource
ISSN:
0009-7322
,
1524-4539
DOI:
10.1161/circ.146.suppl_1.10020
Language:
English
Publisher:
Ovid Technologies (Wolters Kluwer Health)
Publication Date:
2022
detail.hit.zdb_id:
1466401-X
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