In:
The Journal of Immunology, The American Association of Immunologists, Vol. 194, No. 1_Supplement ( 2015-05-01), p. 59.15-59.15
Abstract:
Bcl6, a POZ transcription factor, plays an essential role in the tumorgenensis, inflammation and development, but its role in the antiviral response has never been established. Here, we demonstrate that Bcl6 unexpectedly functions to inhibit RIG-I-mediated antiviral signaling and impedes the clearance of viral infection. More importantly, we identify that miR-127 as a upstream regulator of Bcl6, and the subsequent co-repressive complex in the initiation of RIG-I-driven response. This finding extends our knowledge about mitochondrial antiviral mechanisms and proposes a novel corepressor network required for the coordination of the innate immune response.
Type of Medium:
Online Resource
ISSN:
0022-1767
,
1550-6606
DOI:
10.4049/jimmunol.194.Supp.59.15
Language:
English
Publisher:
The American Association of Immunologists
Publication Date:
2015
detail.hit.zdb_id:
1475085-5
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