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  • 1
    In: Autophagy, Informa UK Limited, Vol. 12, No. 1 ( 2016-01-02), p. 1-222
    Type of Medium: Online Resource
    ISSN: 1554-8627 , 1554-8635
    Language: English
    Publisher: Informa UK Limited
    Publication Date: 2016
    detail.hit.zdb_id: 2262043-6
    SSG: 12
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  • 2
    In: World Journal of Otorhinolaryngology - Head and Neck Surgery, Wiley, Vol. 10, No. 2 ( 2024-06), p. 113-120
    Abstract: This cross‐sectional study aimed to determine the epidemiology of olfactory and gustatory dysfunctions related to COVID‐19 in China. Methods This study was conducted by 45 tertiary Grade‐A hospitals in China. Online and offline questionnaire data were obtained from patients infected with COVID‐19 between December 28, 2022, and February 21, 2023. The collected information included basic demographics, medical history, smoking and drinking history, vaccination history, changes in olfactory and gustatory functions before and after infection, and other postinfection symptoms, as well as the duration and improvement status of olfactory and gustatory disorders. Results Complete questionnaires were obtained from 35,566 subjects. The overall incidence of olfactory and taste dysfunction was 67.75%. Being female or being a cigarette smoker increased the likelihood of developing olfactory and taste dysfunction. Having received four doses of the vaccine or having good oral health or being a alcohol drinker decreased the risk of such dysfunction. Before infection, the average olfactory and taste VAS scores were 8.41 and 8.51, respectively; after infection, they decreased to 3.69 and 4.29 and recovered to 5.83 and 6.55 by the time of the survey. The median duration of dysosmia and dysgeusia was 15 and 12 days, respectively, with 0.5% of patients having symptoms lasting for more than 28 days. The overall self‐reported improvement rate was 59.16%. Recovery was higher in males, never smokers, those who received two or three vaccine doses, and those that had never experienced dental health issues, or chronic accompanying symptoms. Conclusions The incidence of dysosmia and dysgeusia following infection with the SARS‐CoV‐2 virus is high in China. Incidence and prognosis are influenced by several factors, including sex, SARS‐CoV‐2 vaccination, history of head‐facial trauma, nasal and oral health status, smoking and drinking history, and the persistence of accompanying symptoms.
    Type of Medium: Online Resource
    ISSN: 2095-8811 , 2589-1081
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2024
    detail.hit.zdb_id: 2999715-X
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  • 3
    Online Resource
    Online Resource
    Acta Physica Sinica, Chinese Physical Society and Institute of Physics, Chinese Academy of Sciences ; 2024
    In:  Acta Physica Sinica Vol. 73, No. 7 ( 2024), p. 072801-
    In: Acta Physica Sinica, Acta Physica Sinica, Chinese Physical Society and Institute of Physics, Chinese Academy of Sciences, Vol. 73, No. 7 ( 2024), p. 072801-
    Abstract: Neutron capture reaction is one of the neutron reactions and plays an important role in using reactor control rods and shell materials, designing nuclear device structures, and studying nuclear astrophysics S processes and element origins. The 4π BaF 〈 sub 〉 2 〈 /sub 〉 detection device has advantages such as high time resolution, low neutron sensitivity, and high detection efficiency, thus making it suitable for measuring neutron radiation capture reaction cross-section data. In order to fill the gap in our neutron capture reaction data in the keV energy range and improve their accuracy, the Key Laboratory of Nuclear Data at the Chinese Institute of Atomic Energy (CIAE) has established a Gamma Total Absorption Facility (GTAF), which consists of 28 hexagonal BaF 〈 sub 〉 2 〈 /sub 〉 crystals and 12 pentagonal BaF 〈 sub 〉 2 〈 /sub 〉 crystals to form a spherical shell with an external diameter of 25 cm and an internal diameter of 10 cm, covering 95.2% of the solid angles. The Back-n beam line of the Chinese Spallation Neutron Source (CSNS) is a back-streaming white beam line that covers neutron energy ranging from a few eV to several hundred MeV, making it suitable for measuring neutron capture cross-sections. The reaction cross-section data of 〈 sup 〉 197 〈 /sup 〉 Au is measured by using GTAF on the Back-n beam line. The measurement data are preliminarily background deducted through energy screening, PSD method, and crystal multiplicity screening. Subsequently, the background is analyzed and deducted based on the measurement data of 〈 sup 〉 nat 〈 /sup 〉 C and empty samples, and the yield of 〈 sup 〉 197 〈 /sup 〉 Au capture reaction is obtained. Resonance parameters are a set of parameters extracted from experimental data to describe the resonance curve, which can eliminate the influence of experimental conditions on resonance data and are more important than the cross-section obtained from experiments. The resonance energy, neutron resonance width, and gamma resonance width parameters of 〈 sup 〉 197 〈 /sup 〉 Au at 1–100 eV are fitted by using the SAMMY program. From the comparison between the resonance curves obtained from experimental measurements and the resonance parameters obtained from fitting with the ENDF/B-VIII.0 database, it can follow that the experimental measurement results are in good agreement with the database, nevertheless, there exist some differences in the resonance parameter, which may be due to the GTAF energy resolution, Back-n neutron spectrum measurement accuracy, and the experimental background deduction method. Our next work is to identify the sources of difference.
    Type of Medium: Online Resource
    ISSN: 1000-3290 , 1000-3290
    Language: Unknown
    Publisher: Acta Physica Sinica, Chinese Physical Society and Institute of Physics, Chinese Academy of Sciences
    Publication Date: 2024
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  • 4
    Online Resource
    Online Resource
    Acta Physica Sinica, Chinese Physical Society and Institute of Physics, Chinese Academy of Sciences ; 2021
    In:  Acta Physica Sinica Vol. 70, No. 22 ( 2021), p. 222801-
    In: Acta Physica Sinica, Acta Physica Sinica, Chinese Physical Society and Institute of Physics, Chinese Academy of Sciences, Vol. 70, No. 22 ( 2021), p. 222801-
    Abstract: The data of neutron capture cross section are very important for the research of nuclear astrophysics, advanced nuclear energy development. Owing to the limitation of neutron source and detector, the experimental data of neutron capture cross section in an energy range of 1 eV–10 keV were almost blank in China. The first Chinese gamma-ray total absorption facility has been constructed in the key laboratory of nuclear data at China institute of atomic energy, which consists of 40 BaF〈sub〉2〈/sub〉 detector units. The BaF〈sub〉2〈/sub〉 crystal shell with a thickness of 15 cm and an inner radius of 10 cm covers 95.2% of the solid angle. On-line measurement method of neutron capture reaction cross section is established on the back-streaming white neutron source of China spallation neutron source by using the upgraded facility. The cross section of 〈sup〉197〈/sup〉Au neutron capture reaction is measured for the first time under the experimental condition of irregular 30 mm neutron beam spot. The measured position of resonance peak is well consistent with the relevant data of ENDF evaluation database, which verifies the reliability of the measurement device and measurement technology, and thus laying the foundation for the acquisition of high precision cross section in future.
    Type of Medium: Online Resource
    ISSN: 1000-3290 , 1000-3290
    Language: Unknown
    Publisher: Acta Physica Sinica, Chinese Physical Society and Institute of Physics, Chinese Academy of Sciences
    Publication Date: 2021
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  • 5
    In: JAMA, American Medical Association (AMA), Vol. 327, No. 19 ( 2022-05-17), p. 1888-
    Type of Medium: Online Resource
    ISSN: 0098-7484
    RVK:
    Language: English
    Publisher: American Medical Association (AMA)
    Publication Date: 2022
    detail.hit.zdb_id: 2958-0
    detail.hit.zdb_id: 2018410-4
    SSG: 5,21
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  • 6
    Online Resource
    Online Resource
    Acta Physica Sinica, Chinese Physical Society and Institute of Physics, Chinese Academy of Sciences ; 2021
    In:  Acta Physica Sinica Vol. 70, No. 8 ( 2021), p. 082901-
    In: Acta Physica Sinica, Acta Physica Sinica, Chinese Physical Society and Institute of Physics, Chinese Academy of Sciences, Vol. 70, No. 8 ( 2021), p. 082901-
    Abstract: At present, there exist few proton-beam terminals for the detector calibration in the world. Meanwhile, most of these terminals provide monoenergetic protons. Back-n white neutron source from China Spallation Neutron Source(CSNS) was put into operation in 2018. Based on the white neutron flux ranging from 0.5 eV to 200 MeV from the CSNS Back-n white neutron source, continuous-energy protons involved in a wide energy spectrum can be acquired from the 〈sup〉1〈/sup〉H(n, el) reaction. Adopting this method, a new research platform for researches such as proton calibration is realized at CSNS. As hydrogen exists as gas at normal temperature and pressure, in the selecting of the proton-converting target, the hydrogen-rich compounds are preferential considered. Considering the reaction cross sections of the 〈sup〉1〈/sup〉H(n, el), 〈sup〉12〈/sup〉C(n, p)〈sup〉12〈/sup〉B, 〈sup〉12〈/sup〉C(n, d)〈sup〉11〈/sup〉B, 〈sup〉12〈/sup〉C(n, t)〈sup〉10〈/sup〉B, 〈sup〉12〈/sup〉C(n, 〈sup〉3〈/sup〉He)〈sup〉10〈/sup〉Be, 〈sup〉12〈/sup〉C(n, α)〈sup〉9〈/sup〉Be and 〈sup〉1〈/sup〉H(n, γ)〈sup〉2〈/sup〉H, polyethylene and polypropylene are suitable for serving as targets in this research. Based on a 3U PXIe, digitizers with 1 GSps sampling rate and 12 bit resolution are utilized to digitize and record the output signals of telescopes. The time and amplitude information of each signal are extracted from its recorded waveform. Proton fluxes can be calculated by using the neutron energy spectrum and the cross section of the 〈sup〉1〈/sup〉H(n, el) reaction. Using the γ-flash event as the starting time of the time-of-flight (TOF) and the time information of signal in detector as the stopping time, the kinematic energy of each secondary proton can be deduced from the TOF and the angle of the detector. A calibration experiment on three charged particle telescopes, with each telescope consisting of a silicon detector and a CsI(Tl) detector, is carried out on this research platform. The readout methods of the CsI(Tl) detectors in these three telescopes are different. In the calibration experiment, Δ〈i〉E-〈/i〉〈i〉E〈/i〉 two-dimensional spectra and amplitude-〈i〉E〈/i〉〈sub〉p〈/sub〉 two-dimensional spectra of these telescopes are obtained. Through comparing these particle identification spectra, the SiPM is chosen as the signal readout method for CsI(Tl) detectors in the charged particle telescopes. These researches provide experimental evidence for the construction of the charged particle telescope at Back-n, and also illustrate the feasibility of wide-energy spectrum proton calibration based on the Back-n white neutron source.
    Type of Medium: Online Resource
    ISSN: 1000-3290 , 1000-3290
    Language: Unknown
    Publisher: Acta Physica Sinica, Chinese Physical Society and Institute of Physics, Chinese Academy of Sciences
    Publication Date: 2021
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  • 7
    Online Resource
    Online Resource
    Acta Physica Sinica, Chinese Physical Society and Institute of Physics, Chinese Academy of Sciences ; 2020
    In:  Acta Physica Sinica Vol. 69, No. 17 ( 2020), p. 172901-
    In: Acta Physica Sinica, Acta Physica Sinica, Chinese Physical Society and Institute of Physics, Chinese Academy of Sciences, Vol. 69, No. 17 ( 2020), p. 172901-
    Abstract: The back-streaming neutron beam line (Back-n) was built in the beginning of 2018, which is part of the China Spallation Neutron Source (CSNS). The Back-n is the first white neutron beam line in China, and its main application is for nuclear data measurement. For most of neutron-induced nuclear reaction measurements based on white neutron facilities, the beam of gamma rays accompanied with neutron beam is one of the most important experimental backgrounds. The back streaming neutron beam is transported directly from the spallation target to the experimental station without any moderator or shielding, the flux of the in-beam gamma rays in the experimental station is much larger than those of these facilities with neutron moderator and shielding. Therefore, it is necessary to consider the influence of in-beam gamma rays on the experimental results. Studies of the in-beam gamma rays are carried out at the back-n. Monte-Carlo simulation is employed to obtain the energy distribution and the time structure of the in-beam gamma rays. According to the simulation results, when the neutron flight time is longer than 1.0 μs the energy distribution of the in-beam gamma rays does not vary with flight time. Therefore, the time structure of these gamma rays can be measured without the correction of the detection efficiency. In this work, the time structure of the in-beam gamma rays in the low neutron energy region is measured by both direct and indirect methods. In the direct measurement, a 〈sup〉6〈/sup〉Li loaded ZnS(Ag) scintillator is located on the neutron beam line and the time of flight method is used to determine the time structure of neutrons and gamma rays. The gamma rays are separated from neutrons with pulse-shape discrimination. The black filter method is used to verify the particle discrimination results. In the indirect measurement, the C〈sub〉6〈/sub〉D〈sub〉6〈/sub〉 scintillation detectors are used to measure the gamma rays scattered off a Pb sample on the way of the neutron beam. The time structure of the in-beam gamma rays is derived from that of the scattered gamma rays. The experimental results are in good agreement with the simulations with the time-of-flight between 12 μs and 2.0 ms. Besides, according to the simulation results, the intensity of the in-beam gamma rays is 1.21 × 10〈sup〉6〈/sup〉 s〈sup〉–1〈/sup〉·cm〈sup〉–2〈/sup〉 in the center of the experimental station 2 of Back-n, which is 76.5 m away from the spallation target of CSNS.
    Type of Medium: Online Resource
    ISSN: 1000-3290 , 1000-3290
    Language: Unknown
    Publisher: Acta Physica Sinica, Chinese Physical Society and Institute of Physics, Chinese Academy of Sciences
    Publication Date: 2020
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  • 8
    In: Diabetes, Obesity and Metabolism, Wiley, Vol. 20, No. 9 ( 2018-09), p. 2113-2120
    Abstract: To investigate the pharmacokinetics and pharmacodynamics of a dual‐acting glucokinase activator, dorzagliatin, and its safety, tolerability and effect on pancreatic β‐cell function in Chinese patients with type 2 diabetes (T2D). Materials and methods A total of 24 T2D patients were selected, utilizing a set of predefined clinical biomarkers, and were randomized to receive dorzagliatin 75 mg twice or once daily (BID, QD respectively) for 28 days. Changes in HbA1c and glycaemic parameters from baseline to Day 28 were assessed. In addition, changes in β‐cell function from baseline to Day 32 were evaluated. Results Significant reductions in HbA1c were observed in both regimens on Day 28 (−0.79%, 75 mg BID; −1.22%, 75 mg QD). Similar trends were found in the following parameters, including reductions from baseline in fasting plasma glucose by 1.20 mmol/L and 1.51 mmol/L, in 2‐hour postprandial glucose by 2.48 mmol/L and 5.03 mmol/L, and in glucose AUC 0–24 by 18.59% and 20.98%, for the BID and QD groups, respectively. Both regimens resulted in improvement in β‐cell function as measured by steady state HOMA 2 parameter, %B, which increased by 36.31% and 40.59%, and by dynamic state parameter, ΔC 30 /ΔG 30 , which increased by 24.66% and 167.67%, for the BID and QD groups, respectively. Dorzagliatin was well tolerated in both regimens, with good pharmacokinetic profiles. Conclusions Dorzagliatin treatment for 28 days in Chinese T2D patients, selected according to predefined biomarkers, resulted in significant improvement in β‐cell function and glycaemic control. The safety and pharmacokinetic profile of dorzagliatin supports a subsequent Phase II trial design and continued clinical development.
    Type of Medium: Online Resource
    ISSN: 1462-8902 , 1463-1326
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2018
    detail.hit.zdb_id: 2004918-3
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  • 9
    In: Psychoradiology, Oxford University Press (OUP), Vol. 2, No. 1 ( 2022-06-09), p. 32-42
    Abstract: Despite a growing neuroimaging literature on the pathophysiology of major depressive disorder (MDD), reproducible findings are lacking, probably reflecting mostly small sample sizes and heterogeneity in analytic approaches. To address these issues, the Depression Imaging REsearch ConsorTium (DIRECT) was launched. The REST-meta-MDD project, pooling 2428 functional brain images processed with a standardized pipeline across all participating sites, has been the first effort from DIRECT. In this review, we present an overview of the motivations, rationale, and principal findings of the studies so far from the REST-meta-MDD project. Findings from the first round of analyses of the pooled repository have included alterations in functional connectivity within the default mode network, in whole-brain topological properties, in dynamic features, and in functional lateralization. These well-powered exploratory observations have also provided the basis for future longitudinal hypothesis-driven research. Following these fruitful explorations, DIRECT has proceeded to its second stage of data sharing that seeks to examine ethnicity in brain alterations in MDD by extending the exclusive Chinese original sample to other ethnic groups through international collaborations. A state-of-the-art, surface-based preprocessing pipeline has also been introduced to improve sensitivity. Functional images from patients with bipolar disorder and schizophrenia will be included to identify shared and unique abnormalities across diagnosis boundaries. In addition, large-scale longitudinal studies targeting brain network alterations following antidepressant treatment, aggregation of diffusion tensor images, and the development of functional magnetic resonance imaging-guided neuromodulation approaches are underway. Through these endeavours, we hope to accelerate the translation of functional neuroimaging findings to clinical use, such as evaluating longitudinal effects of antidepressant medications and developing individualized neuromodulation targets, while building an open repository for the scientific community.
    Type of Medium: Online Resource
    ISSN: 2634-4416
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2022
    detail.hit.zdb_id: 3076092-6
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  • 10
    In: Journal of Vascular Surgery: Venous and Lymphatic Disorders, Elsevier BV, ( 2023-5)
    Type of Medium: Online Resource
    ISSN: 2213-333X
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2023
    detail.hit.zdb_id: 2701667-5
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