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  • 1
    Online Resource
    Online Resource
    Astrocytic Epoxyeicosatrienoic Acid Signaling in the Medial Prefrontal Cortex Modulates Depressive-like Behaviors
    Society for Neuroscience ; 2019
    In:  The Journal of Neuroscience Vol. 39, No. 23 ( 2019-06-05), p. 4606-4623
    Details
    In: The Journal of Neuroscience, Society for Neuroscience, Vol. 39, No. 23 ( 2019-06-05), p. 4606-4623
    Type of Medium: Online Resource
    ISSN: 0270-6474 , 1529-2401
    URL: Article
    URL: Article
    DOI: 10.1523/JNEUROSCI.3069-18.2019
    DOI: 10.1523/JNEUROSCI.3069-18.2019.f1-1
    Language: English
    Publisher: Society for Neuroscience
    Publication Date: 2019
    detail.hit.zdb_id: 1475274-8
    SSG: 12
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  • 2
    Online Resource
    Online Resource
    14,15-Epoxyeicosatrienoic Acid Alleviates Pathology in a Mouse Model of Alzheimer's Disease
    Society for Neuroscience ; 2020
    In:  The Journal of Neuroscience Vol. 40, No. 42 ( 2020-10-14), p. 8188-8203
    Details
    In: The Journal of Neuroscience, Society for Neuroscience, Vol. 40, No. 42 ( 2020-10-14), p. 8188-8203
    Abstract: Alzheimer's disease (AD) is the leading cause of late-onset dementia, and there exists an unmet medical need for effective treatments for AD. The accumulation of neurotoxic amyloid-β (Aβ) plaques contributes to the pathophysiology of AD. EPHX2 encoding soluble epoxide hydrolase (sEH)—a key enzyme for epoxyeicosatrienoic acid (EET) signaling that is mainly expressed in lysosomes of astrocytes in the adult brain—is cosited at a locus associated with AD, but it is unclear whether and how it contributes to the pathophysiology of AD. In this report, we show that the pharmacologic inhibition of sEH with 1-trifluoromethoxyphenyl- 3-(1-propionylpiperidin-4-yl) urea (TPPU) or the genetic deletion of Ephx2 reduces Aβ deposition in the brains of both male and female familial Alzheimer's disease (5×FAD) model mice. The inhibition of sEH with TPPU or the genetic deletion of Ephx2 alleviated cognitive deficits and prevented astrocyte reactivation in the brains of 6-month-old male 5×FAD mice. 14,15-EET levels in the brains of these mice were also increased by sEH inhibition. In cultured adult astrocytes treated with TPPU or 14,15-EET, astrocyte Aβ clearance was increased through enhanced lysosomal biogenesis. Infusion of 14,15-EET into the hippocampus of 5×FAD mice prevented the aggregation of Aβ. Notably, a higher concentration of 14,15-EET (200 ng/ml) infusion into the hippocampus reversed Aβ deposition in the brains of 6-month-old male 5×FAD mice. These results indicate that EET signaling, especially 14,15-EET, plays a key role in the pathophysiology of AD, and that targeting this pathway is a potential therapeutic strategy for the treatment of AD. SIGNIFICANCE STATEMENT There are limited treatment options for Alzheimer's disease (AD). EPHX2 encoding soluble epoxide hydrolase (sEH) is located at a locus that is linked to late-onset AD, but its contribution to the pathophysiology of AD is unclear. Here, we demonstrate that sEH inhibition or Ephx2 deletion alleviates pathology in familial Alzheimer's disease (5×FAD) mice. Inhibiting sEH or increasing 14,15-epoxyeicosatrienoic acid (EET) enhanced lysosomal biogenesis and amyloid-β (Aβ) clearance in cultured adult astrocytes. Moreover, the infusion of 14,15-EET into the hippocampus of 5×FAD mice not only prevented the aggregation of Aβ, but also reversed the deposition of Aβ. Thus, 14,15-EET plays a key role in the pathophysiology of AD and therapeutic strategies that target this pathway may be an effective treatment.
    Type of Medium: Online Resource
    ISSN: 0270-6474 , 1529-2401
    URL: Article
    DOI: 10.1523/JNEUROSCI.1246-20.2020
    Language: English
    Publisher: Society for Neuroscience
    Publication Date: 2020
    detail.hit.zdb_id: 1475274-8
    SSG: 12
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  • 3
    Online Resource
    Online Resource
    DataSheet_1.doc
    Frontiers Media SA ; 2023
    In:  Frontiers in Cellular and Infection Microbiology Vol. 12 ( 2023-2-2)
    Details
    In: Frontiers in Cellular and Infection Microbiology, Frontiers Media SA, Vol. 12 ( 2023-2-2)
    Abstract: Cyprinid herpesvirus 2 (CyHV-2) infects gibel carp ( Carassius auratus gibelio ) and causes severe losses. Microbiota in animal guts involves nutrition intake, development, immunity, and disease resistance. However, the relationship between gibel carp gut microbiota and CyHV-2 infection is not well known. Herein, we analyzed the gut microbiota composition and metabolite profiles in CyHV-2-infected and -uninfected fish using high-throughput sequencing and gas chromatography/mass spectrometry. Results showed that CyHV-2 infection significantly changed gut microbiota and metabolite profiles ( p & lt; 0.05). High-throughput sequencing demonstrated that the relative abundance of Aeromonas in the midgut increased dramatically while Cetobacterium decreased. Time-course analysis showed that the number of Aeromonas in the midgut of infected fish increased more than 1,000 times within 5 days post infection. Metabolome analysis illustrated that CyHV-2 infection significantly altered 24 metabolites in the midgut of gibel carp, annotating to the anomaly of digestion and metabolisms of amino acids, carbohydrates, and lipids, such as tryptophan (Trp) metabolism. The Mantel test demonstrated that gut microbiota and metabolite profiles were well related (r = 0.89). Furthermore, Trp metabolism responded to CyHV-2 infection closely was taken as one example to prove the correlation among CyHV-2 infection, metabolites and microbiota in the midgut, and host immunity. Results showed that modulating Trp metabolism could affect the relative abundance of Aeromonas in the midgut of fish, transcription of antiviral cytokines, and CyHV-2 infection. Therefore, we can conclude that CyHV-2 infection significantly perturbed the gut microbiome, disrupted its’ metabolic functions, and caused the proliferation of the opportunistic pathogen Aeromonas . This study also suggests that modulation of the gut microbiome will open a therapeutic opportunity to control CyHV-2 infection in gibel carp.
    Type of Medium: Online Resource
    ISSN: 2235-2988
    URL: Article
    URL: Article
    DOI: 10.3389/fcimb.2022.1017165
    DOI: 10.3389/fcimb.2022.1017165.s001
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2023
    detail.hit.zdb_id: 2619676-1
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  • 4
    Online Resource
    Online Resource
    Dietary PHB Supplementation Strengthens the Gill Immune Barrier and Disease Resistance of Carassius auratus gibelio against CyHV-2 Early Infection
    Hindawi Limited ; 2023
    In:  Aquaculture Research Vol. 2023 ( 2023-6-7), p. 1-15
    Details
    In: Aquaculture Research, Hindawi Limited, Vol. 2023 ( 2023-6-7), p. 1-15
    Abstract: Gibel carp (Carassius auratus gibelio) is an important economic fish species in China, but its development is seriously restricted by the crucian carp hematopoietic organ necrosis caused by Cyprinid herpesvirus 2 (CyHV-2). Gill is the key portal for CyHV-2 primary invasion, and the gill immune barrier is the first defense line against infection. Our previous studies showed that dietary poly-β-hydroxybutyrate (PHB) supplementation can enhance the disease resistance of gibel carps against CyHV-2 infection, and antioxidants play an important role against this infection. However, the effect of PHB supplementation on the gill immune barrier and primary proliferation of CyHV-2 in the gill is unclear. Herein, results showed that (1) PHB supplementation significantly increased the activities of SOD, GST, and other antioxidant-related enzymes in the gill and gill mucus; (2) PHB significantly upregulated the transcription of genes involved in the JAK/STAT signaling pathway, Th1 and Th2 cell differentiation, tryptophan metabolism, and MAPK signaling pathway; (3) PHB effectively reduced the cumulative mortality of fish post-CyHV-2 infection; (4) PHB significantly inhibited primary CyHV-2 proliferation in the gill; (5) at the early stage (6 hpi) of CyHV-2 infection, the transcription of IFN-γ, IFN-γR, TNF-α, JUN, TCR-β, IL-4R, STAT1, and AhR in the gill was significantly upregulated by 14.15-folds, 6.55-folds, 9.32-folds, 6.77-folds, 9.84-folds, 5.55-folds, 9.11-folds and 13.06-folds, respectively; and (6) during the late stages (96 hpi and 168 hpi) of infection, some genes in the kidney and intestine were continuously upregulated. In conclusion, PHB can improve the antioxidant capacity of the gill, enhance the immune response, and inhibit the viral proliferation in the gill at the early infection stage. It is of great significance for us to develop novel prevention strategies to control CyHV-2 infection, considering immuno-modulation of the primary invasion organ, the gill, and host antioxidation.
    Type of Medium: Online Resource
    ISSN: 1365-2109 , 1355-557X
    URL: Article
    DOI: 10.1155/2023/7685847
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2023
    detail.hit.zdb_id: 2207423-5
    detail.hit.zdb_id: 1227359-4
    detail.hit.zdb_id: 2019895-4
    SSG: 21,3
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  • 5
    Online Resource
    Online Resource
    Rifampicin impairs adipogenesis by suppressing NRF2-ARE activity in mice fed a high-fat diet
    Elsevier BV ; 2021
    In:  Toxicology and Applied Pharmacology Vol. 413 ( 2021-02), p. 115393-
    Details
    In: Toxicology and Applied Pharmacology, Elsevier BV, Vol. 413 ( 2021-02), p. 115393-
    Type of Medium: Online Resource
    ISSN: 0041-008X
    URL: Article
    DOI: 10.1016/j.taap.2020.115393
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2021
    detail.hit.zdb_id: 1471923-X
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  • 6
    Online Resource
    Online Resource
    Adolescent expectancy-value motivation and learning: A disconnected case in physical education
    Elsevier BV ; 2010
    In:  Learning and Individual Differences Vol. 20, No. 5 ( 2010-10), p. 512-516
    Details
    In: Learning and Individual Differences, Elsevier BV, Vol. 20, No. 5 ( 2010-10), p. 512-516
    Type of Medium: Online Resource
    ISSN: 1041-6080
    URL: Article
    DOI: 10.1016/j.lindif.2010.04.013
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2010
    detail.hit.zdb_id: 2002113-6
    SSG: 5,2
    SSG: 5,3
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  • 7
    Online Resource
    Online Resource
    Improving students’ knowledge and values in physical education through Physical Best lessons
    SAGE Publications ; 2017
    In:  European Physical Education Review Vol. 23, No. 2 ( 2017-05), p. 223-236
    Details
    In: European Physical Education Review, SAGE Publications, Vol. 23, No. 2 ( 2017-05), p. 223-236
    Abstract: This study examined the effects of using Physical Best lessons to promote adolescent energy balance knowledge and task values. Seventh graders ( N = 90) were randomly assigned to the experiment and the comparison groups. The experiment group took 10 selected Physical Best lessons, while the comparison experienced 10 district lessons. Pre- and post-measurements of knowledge and task values were taken at the beginning and the end of the experiment. Analysis of covariance and multivariate analysis of variance were conducted to test the difference over time and between the groups in energy balance knowledge test scores and task values. Both groups improved knowledge test scores, but the experiment group scored significantly higher than the comparison, controlling for the pre-test. The comparison group reported higher initial attainment values which declined over time, while the experiment group increased. The findings suggested that Physical Best lessons were effective ( η p 2 =.18) in improving students’ energy balance knowledge in 10 structured lessons, and that students reported a higher perceived value about the importance of physical education after they learned energy balance and exercise principles. Perhaps these concepts should be taught in physical education to improve student knowledge and perceived values of the subject.
    Type of Medium: Online Resource
    ISSN: 1356-336X , 1741-2749
    URL: Article
    DOI: 10.1177/1356336X16645366
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2017
    detail.hit.zdb_id: 2025496-9
    SSG: 31
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  • 8
    Online Resource
    Online Resource
    The meaning of youth physical activity experiences among individuals with psoriasis: A retrospective inquiry
    SAGE Publications ; 2019
    In:  European Physical Education Review Vol. 25, No. 2 ( 2019-05), p. 374-388
    Details
    In: European Physical Education Review, SAGE Publications, Vol. 25, No. 2 ( 2019-05), p. 374-388
    Abstract: The purpose of this study was to examine the meaning that individuals with psoriasis ascribed to their youth physical activity experiences. This qualitative, retrospective inquiry was based on an interpretative phenomenological analysis. A purposive sample of six participants (ages 20–46; four female, two male) residing in the United States were included. Semi-structured, audio-taped telephone interviews and reflective field notes acted as sources of data for this study. Thematic development was undertaken using a four-step interpretative phenomenological analysis process and themes identified across participants were summarized, presented as results, and discussed concurrently. Based on the data analysis, three interrelated themes were constructed from the participant transcripts: (a) “I just stopped signing up”: the impact of physical discomfort; (b) “kids started calling me ‘Flake’”: embarrassment, social anxiety, and bullying; and (c) “I felt like he was calling me out”: disclosing psoriasis to stakeholders. These three constructed themes provide unique insight into the embodied experiences of those with psoriasis, and fill a previous gap in the extant literature. Practitioners aiming to increase physical activity engagement among this population can use these findings to design more effective programmes and strategies that address the needs identified in this investigation.
    Type of Medium: Online Resource
    ISSN: 1356-336X , 1741-2749
    URL: Article
    DOI: 10.1177/1356336X17740143
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2019
    detail.hit.zdb_id: 2025496-9
    SSG: 31
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  • 9
    Online Resource
    Online Resource
    Fitness testing experiences in integrated physical education as reflected by adults with visual impairments
    SAGE Publications ; 2020
    In:  European Physical Education Review Vol. 26, No. 4 ( 2020-11), p. 747-763
    Details
    In: European Physical Education Review, SAGE Publications, Vol. 26, No. 4 ( 2020-11), p. 747-763
    Abstract: The purpose of this study was to describe the experiences of adults with visual impairments regarding fitness testing during their integrated physical education experiences. An interpretative phenomenological analysis research approach was used and 11 adults (ages 20–35 years) with visual impairments acted as participants. The primary sources of data were semi-structured audiotaped telephone interviews and reflective interview notes. Thematic development was undertaken using a three-step analytical process. Based on the data analysis, the following three interrelated themes were constructed from the data: (a) ‘decent at sit-ups, but the others were embarrassing’: mixed feelings about performance; (b) ‘I couldn’t reach my full potential’: forced exclusion/inclusion; and (c) ‘I felt like a museum exhibit’: navigating unwanted social attention. These themes extend the current literature by describing salient features of fitness testing that influence the meaning that individuals with visual impairments place on those experiences.
    Type of Medium: Online Resource
    ISSN: 1356-336X , 1741-2749
    URL: Article
    DOI: 10.1177/1356336X19882057
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2020
    detail.hit.zdb_id: 2025496-9
    SSG: 31
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  • 10
    Online Resource
    Online Resource
    Muyin extract inhibits non-small-cell lung cancer growth by inducing autophagy and apoptosis in vitro and in vivo
    Elsevier BV ; 2022
    In:  Phytomedicine Vol. 96 ( 2022-02), p. 153834-
    Details
    In: Phytomedicine, Elsevier BV, Vol. 96 ( 2022-02), p. 153834-
    Type of Medium: Online Resource
    ISSN: 0944-7113
    URL: Article
    DOI: 10.1016/j.phymed.2021.153834
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2022
    detail.hit.zdb_id: 2040195-4
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