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  • 1
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    Table1.XLSX
    Frontiers Media SA ; 2023
    In:  Frontiers in Earth Science Vol. 11 ( 2023-8-30)
    Details
    In: Frontiers in Earth Science, Frontiers Media SA, Vol. 11 ( 2023-8-30)
    Abstract: Thick and hard key stratum working faces are characterized by frequent mine tremors and significant ground tremors during mining which seriously threaten the safety production of the mine. With working face (4-5) 06 of Xinjiang Liuhuanggou Coal Mine as the engineering background, using field investigation, microseismic monitoring, and theoretical analysis, a mining-induced seismicity prediction method and damage assessment of surface buildings for thick and hard key stratum working faces is proposed, which is based on the evolution characteristics of overlying strata spatial structure and the motion state of the key stratum. The results of the study are as follows: 1) The movement law of overlying strata is the basis of mining-induced seismicity prediction for working faces. The magnitude of the risk of mining-induced seismicity occurrence is mainly related to the boundary conditions of the working face, the thickness of the key stratum, the distance from the coal seam to the key stratum, the height of the overlying strata spatial structure, and the fracture step of the key stratum. 2) The mining-induced seismicity energy contains the original accumulation elastic energy of the key stratum, the transfer elastic energy of low rock strata, and the accumulation elastic energy of gravity work. Based on this, a mechanical model of surface building damage induced by the release of mining-induced seismicity energy was established. A ground vibration damage boundary and vibration induction boundary under the action of strong mining-induced seismicity were proposed, and the service life of buildings when they reach the critical damage value under the action of frequent mining-induced seismicity was obtained. 3) The temporal and spatial distribution law of mining-induced seismicity activities in thick and hard key stratum working faces was revealed. According to the results of micro-seismic monitoring, the “zonality” characteristics of the time series and the “transition” law of spatial distribution of mining-induced seismicity verified the reliability of the mining-induced seismicity prediction method. The research results provide a theoretical basis for predicting mining-induced seismicity and assessing the risk of induced disasters during the mining process of thick and hard key stratum working faces, and can provide technical support for mining-induced seismicity prevention and control and safety production in mines with similar conditions.
    Type of Medium: Online Resource
    ISSN: 2296-6463
    URL: Article
    URL: Article
    DOI: 10.3389/feart.2023.1238055
    DOI: 10.3389/feart.2023.1238055.s001
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2023
    detail.hit.zdb_id: 2741235-0
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  • 2
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    Optimization Analysis of Over-Sized Section Open-Off Cut Failure and Support
    Springer Science and Business Media LLC ; 2020
    In:  Geotechnical and Geological Engineering Vol. 38, No. 3 ( 2020-06), p. 3283-3290
    Details
    In: Geotechnical and Geological Engineering, Springer Science and Business Media LLC, Vol. 38, No. 3 ( 2020-06), p. 3283-3290
    Type of Medium: Online Resource
    ISSN: 0960-3182 , 1573-1529
    URL: Article
    DOI: 10.1007/s10706-019-01174-8
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2020
    detail.hit.zdb_id: 2012363-2
    SSG: 19,1
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  • 3
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    The Single-Channel Microseismic Mine Signal Denoising Method and Application Based on Frequency Domain Singular Value Decomposition (FSVD)
    MDPI AG ; 2023
    In:  Sustainability Vol. 15, No. 13 ( 2023-07-05), p. 10588-
    Details
    In: Sustainability, MDPI AG, Vol. 15, No. 13 ( 2023-07-05), p. 10588-
    Abstract: The purpose of denoising microseismic mine signals (MMS) is to extract relevant signals from background interference, enabling their utilization in wave classification, identification, time analysis, location calculations, and detailed mining feature analysis, among other applications. To enhance the signal-to-noise ratio (SNR) of single-channel MMS, a frequency-domain denoising method based on the Fourier transform, inverse transform, and singular value decomposition was proposed, along with its processing workflow. The establishment of key parameters, such as time delay, τ, reconstruction order, k, Hankel matrix length, n, and dimension, m, were introduced. The reconstruction order for SVD was determined by introducing the energy difference spectrum, E, and the denoised two-dimensional microseismic time series was obtained based on the SVD recovery principle. Through the analysis and processing of three types of typical microseismic waveforms in mining (blast, rock burst, and background noise) and with the evaluation of four indicators, SNR, ESN, RMSE, and STI, the results show that the SNR is improved by more than 10 dB after FSVD processing, indicating a strong noise suppression capability. This method is of significant importance for the rapid analysis and processing of microseismic signals in mining, as well as subsequently and accurately picking the initial arrival times and the exploration and analysis of microseismic signal characteristics in mines.
    Type of Medium: Online Resource
    ISSN: 2071-1050
    URL: Article
    DOI: 10.3390/su151310588
    Language: English
    Publisher: MDPI AG
    Publication Date: 2023
    detail.hit.zdb_id: 2518383-7
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  • 4
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    Identification of Darunavir Derivatives for Inhibition of SARS-CoV-2 3CLpro
    MDPI AG ; 2022
    In:  International Journal of Molecular Sciences Vol. 23, No. 24 ( 2022-12-16), p. 16011-
    Details
    In: International Journal of Molecular Sciences, MDPI AG, Vol. 23, No. 24 ( 2022-12-16), p. 16011-
    Abstract: The effective antiviral agents that treat severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are urgently needed around the world. The 3C-like protease (3CLpro) of SARS-CoV-2 plays a pivotal role in virus replication; it also has become an important therapeutic target for the infection of SARS-CoV-2. In this work, we have identified Darunavir derivatives that inhibit the 3CLpro through a high-throughput screening method based on a fluorescence resonance energy transfer (FRET) assay in vitro. We found that the compounds 29# and 50# containing polyphenol and caffeine derivatives as the P2 ligand, respectively, exhibited favorable anti-3CLpro potency with EC50 values of 6.3 μM and 3.5 μM and were shown to bind to SARS-CoV-2 3CLpro in vitro. Moreover, we analyzed the binding mode of the DRV in the 3CLpro through molecular docking. Importantly, 29# and 50# exhibited a similar activity against the protease in Omicron variants. The inhibitory effect of compounds 29# and 50# on the SARS-CoV-2 3CLpro warrants that they are worth being the template to design functionally improved inhibitors for the treatment of COVID-19.
    Type of Medium: Online Resource
    ISSN: 1422-0067
    URL: Article
    DOI: 10.3390/ijms232416011
    Language: English
    Publisher: MDPI AG
    Publication Date: 2022
    detail.hit.zdb_id: 2019364-6
    SSG: 12
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  • 5
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    Discovery and optimization of 2-((1H-indol-3-yl)thio)-N-benzyl-acetamides as novel SARS-CoV-2 RdRp inhibitors
    Elsevier BV ; 2021
    In:  European Journal of Medicinal Chemistry Vol. 223 ( 2021-11), p. 113622-
    Details
    In: European Journal of Medicinal Chemistry, Elsevier BV, Vol. 223 ( 2021-11), p. 113622-
    Type of Medium: Online Resource
    ISSN: 0223-5234
    URL: Article
    DOI: 10.1016/j.ejmech.2021.113622
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2021
    detail.hit.zdb_id: 2005170-0
    SSG: 15,3
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  • 6
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    Salvianolic Acid B Regulates Oxidative Stress, Autophagy and Apoptosis against Cyclophosphamide-Induced Hepatic Injury in Nile Tilapia (Oreochromis niloticus)
    MDPI AG ; 2023
    In:  Animals Vol. 13, No. 3 ( 2023-01-18), p. 341-
    Details
    In: Animals, MDPI AG, Vol. 13, No. 3 ( 2023-01-18), p. 341-
    Abstract: Salvianolic acid B (Sal B), as one of the main water-soluble components of Salvia miltiorrhizae, has significant pharmacological activities, including antioxidant, free radical elimination and biofilm protection actions. However, the protective effect of Sal B on Nile tilapia and the underlying mechanism are rarely reported. Therefore, the aim of this study was to evaluate the effects of Sal B on antioxidant stress, apoptosis and autophagy in Nile tilapia liver. In this experiment, Nile tilapia were fed diets containing sal B (0.25, 0.50 and 0.75 g·kg−1) for 60 days, and then the oxidative hepatic injury of the tilapia was induced via intrapleural injection of 50 g·kg−1 cyclophosphamide (CTX) three times. After the final exposure to CTX, the Nile tilapia were weighed and blood and liver samples were collected for the detection of growth and biochemical indicators, pathological observations and TUNEL detection, as well as the determination of mRNA expression levels. The results showed that after the CTX treatment, the liver was severely damaged, the antioxidant capacity of the Nile tilapia was significantly decreased and the hepatocyte autophagy and apoptosis levels were significantly increased. Meanwhile, dietary Sal B can not only significantly improve the growth performance of tilapia and effectively reduce CTX-induced liver morphological lesions, but can also alleviate CTX-induced hepatocyte autophagy and apoptosis. In addition, Sal B also significantly regulated the expression of genes related to antioxidative stress, autophagy and apoptosis pathways. This suggested that the hepatoprotective effect of Sal B may be achieved through various pathways, including scavenging free radicals and inhibiting hepatocyte apoptosis and autophagy.
    Type of Medium: Online Resource
    ISSN: 2076-2615
    URL: Article
    DOI: 10.3390/ani13030341
    Language: English
    Publisher: MDPI AG
    Publication Date: 2023
    detail.hit.zdb_id: 2606558-7
    SSG: 23
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  • 7
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    An Experimental Investigation on the Relationship between MS Frequency Response and Coal and Gas Outburst
    Hindawi Limited ; 2018
    In:  Shock and Vibration Vol. 2018 ( 2018-06-26), p. 1-13
    Details
    In: Shock and Vibration, Hindawi Limited, Vol. 2018 ( 2018-06-26), p. 1-13
    Abstract: Microseismic (MS) frequency response is an important part of high-efficiency data mining to achieve the aim of coal and gas outburst (CGOB) early warning. Based on the variation pattern of acoustic emission (AE) signal in the coal failure process, the experimental characteristics of MS activity and typical signals CGOB were obtained in this study. First, the AE behavior of coal failure experiment was studied, and an explanation of laws was provided as follows: the fracture behavior of coal sample exhibits certain characteristics of AE response in terms of AE event count, signal amplitude, and frequency; each stage has its own physical meaning during the process of loading test. Based on these laws, CGOB experiments were carried out using a large CGOB physical simulation system with a MS monitoring system. Notching filter and wavelet packet transform technique were used in the denoising and feature extraction of six typical MS events (signals). The features of each stage, including the time-frequency domain, were extracted and quantitatively expressed. We finally arrive at the following conclusions: (1) CGOB exhibits significantly periodic characteristics, and each CGOB stage corresponds to the significant response characteristics of MS. CGOB presents varying characteristics, such as “valley-peaks-valley”. (2) From the incubation stage to happen stage of outburst, the spectrum significantly moved from extremely low frequency (100-200 Hz) to high-frequency band (approach to 1600 Hz). During the residual stage, MS frequency manifested the concentration distribution (50 Hz) and offered the advantage of energy concentration. (3) The phenomenon of signal energy also shows the trend of energy transform low to high and to low modes along with the process. Signals total energy distribution (42.81%, 1,437.5-1,812.5 Hz) in the happen stage are markedly larger than those of events in incubation stage (7.01%) and residual stage (1.44%). The methodology presented in this paper for CGOB signal analysis provides a new method to obtain MS response precursor and predict CGOB disaster. This approach can be useful for rockburst anticipation and control during mining in gas and highly stressed coal mines.
    Type of Medium: Online Resource
    ISSN: 1070-9622 , 1875-9203
    URL: Article
    DOI: 10.1155/2018/8465651
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2018
    detail.hit.zdb_id: 2070162-7
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  • 8
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    Table_1.DOCX
    Frontiers Media SA ; 2021
    In:  Frontiers in Microbiology Vol. 12 ( 2021-12-23)
    Details
    In: Frontiers in Microbiology, Frontiers Media SA, Vol. 12 ( 2021-12-23)
    Abstract: To reduce water utilization, limit environmental pollution, and guarantee aquatic production and quality, the in-pond raceway recirculating culture system (IPRS) has been developed and is widely used. The effectiveness and sustainability of IPRSs rely on a good understanding of the ecological processes related to bacterial communities in the purification area. In this study, we investigated the dynamics and assembly mechanisms of benthic bacterial communities in the purification area of an industrial-scale IRPS. We found significant temporal and spatial variations in the sediment characteristics and benthic bacterial communities of the IPRS, although correlation analyses revealed a very limited relationship between them. Among the different culture stages, we identified numerous benthic bacteria with different abundances. Abundances of the phyla Bacteroidota and Desulfobacterota decreased whereas those of Myxococcota and Gemmatimonadota increased as the culture cycle progressed. Co-occurrence networks revealed that the bacterial community was less complex but more stable in the IPRS at the final stage compared with the initial stage. The neutral community model (NCM) showed that stochastic processes were the dominant ecological processes shaping the assembly of the benthic bacterial community. The null model suggested that homogenizing dispersal was more powerful than dispersal limitation and drift in regulating the assembly of the community. These findings indicate that the benthic microbial communities in purification areas of the IPRS may not be affected by the deposited wastes, and a more stable benthic microbial communities were formed and mainly driven by stochastic processes. However, the benthic microbial communities in the purification area at the end of the culturing stage was characterized by potentially inhibited organic matter degradation and carbon and sulfur cycling abilities, which was not corresponding to the purification area’s function. From this point on, the IPRS, especially the purification area was needed to be further optimized and improved.
    Type of Medium: Online Resource
    ISSN: 1664-302X
    URL: Article
    URL: Article
    DOI: 10.3389/fmicb.2021.797817
    DOI: 10.3389/fmicb.2021.797817.s001
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2021
    detail.hit.zdb_id: 2587354-4
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  • 9
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    A Combined Denoising Method for Microseismic Signals from Coal Seam Hydraulic Fracturing: Multithreshold Wavelet Packet Transform and Improved Hilbert-Huang Transform
    Hindawi Limited ; 2021
    In:  Shock and Vibration Vol. 2021 ( 2021-2-19), p. 1-15
    Details
    In: Shock and Vibration, Hindawi Limited, Vol. 2021 ( 2021-2-19), p. 1-15
    Abstract: Coal seam hydraulic fracturing (CSHF) has recently been applied to mitigate frequent regional rockburst risk in deep mines before mining practice, as an effective substitute for conventional labor-intensive and time-consuming rockburst prevention measures. Due to the complex nature of CSHF microseismic signals—e.g., nonstationary, transient, and low signal-to-noise ratio—conventional denoising methods tend to yield undesirable results that may preclude reliable evaluation of hydraulic fracturing performance using microseismic data. We propose an advanced denoising method MWPT-IHHT to achieve twice denoising in a fine and adaptive manner. This method combines a multithreshold wavelet packet transform (MWPT) and an improved Hilbert-Huang transform (IHHT), with each being improved compared to their conventional counterparts. A quantitative comparison using synthetic signals suggests the outperformance of the proposed method over the commonly used denoising methods in suppressing noises in terms of signal-to-noise ratio, signal similarity, and energy percentage. The desirable denoising results of two typical real CSHF signals in a CSHF test at Huafeng Coal Mine further demonstrate the applicability and effectiveness of the proposed MWPT-IHHT method.
    Type of Medium: Online Resource
    ISSN: 1875-9203 , 1070-9622
    URL: Article
    DOI: 10.1155/2021/6623861
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2021
    detail.hit.zdb_id: 2070162-7
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  • 10
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    Analysis of Deformation Damage in Deep Well Roadway and Supporting Countermeasures
    Springer Science and Business Media LLC ; 2020
    In:  Geotechnical and Geological Engineering Vol. 38, No. 6 ( 2020-12), p. 6899-6908
    Details
    In: Geotechnical and Geological Engineering, Springer Science and Business Media LLC, Vol. 38, No. 6 ( 2020-12), p. 6899-6908
    Type of Medium: Online Resource
    ISSN: 0960-3182 , 1573-1529
    URL: Article
    DOI: 10.1007/s10706-020-01416-0
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2020
    detail.hit.zdb_id: 2012363-2
    SSG: 19,1
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