In:
Angewandte Chemie, Wiley, Vol. 131, No. 1 ( 2019-01-02), p. 318-322
Abstract:
We report a general, practical, and scalable means of preparing deuterated aldehydes from aromatic and aliphatic carboxylic acids with D 2 O as an inexpensive deuterium source. The use of Ph 3 P as an O‐atom transfer reagent can facilitate the deoxygenation of aromatic acids, while Ph 2 POEt is a better O‐atom transfer reagent for aliphatic acids. The highly precise deoxygenation of complex carboxylic acids makes this protocol promising for late‐stage deoxygenative deuteration of natural product derivatives and pharmaceutical compounds.
Type of Medium:
Online Resource
ISSN:
0044-8249
,
1521-3757
DOI:
10.1002/ange.201811522
Language:
English
Publisher:
Wiley
Publication Date:
2019
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505868-5
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506609-8
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514305-6
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505872-7
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1479266-7
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505867-3
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506259-7
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