In:
PeerJ, PeerJ, Vol. 10 ( 2022-09-28), p. e13965-
Abstract:
Fatigue is one of the most prevalent symptoms among pregnant women. In patients with various diseases, pro-inflammatory cytokines are associated with fatigue; however, such associations are unknown in pregnant women. Objectives The objective of this study was to examine the associations between pro-inflammatory cytokines and prenatal fatigue. Methods A cross-sectional study was conducted on 271 pregnant Chinese women in their third trimester of pregnancy. Patient-reported Outcome Measurement Information System (PROMIS) was used to evaluate women’s prenatal fatigue. Using enzyme-linked immunosorbent assay (ELISA), the serum concentrations of four pro-inflammatory cytokines, including tumor necrosis factor alpha (TNF- α ), interleukin 1 beta (IL-1 β ), interleukin 6 (IL-6) and interleukin 8 (IL-8), were measured. The data was analyzed by correlation analysis and general linear regression analysis. Results In this sample, the mean (standard deviation) of fatigue scores was 51.94 (10.79). TNF- α ( r = 0.21, p 〈 0.001), IL-6 ( r = 0.134, p = 0.027) and IL-8 ( r = 0.209, p = 0.001) were positively correlated to prenatal fatigue, although IL-1 β was not. TNF- α ( β = 0.263, p 〈 0.001), along with sleep quality ( β = 0.27, p 〈 0.001) and depression ( β = 0.376, p 〈 0.001) independently predicted prenatal fatigue. Conclusions TNF- α was identified as an independent biomarker for prenatal fatigue in our study. Reducing pro-inflammatory cytokines may be a unique method for lowering prenatal fatigue and, consequently, enhancing mother and child health.
Type of Medium:
Online Resource
ISSN:
2167-8359
DOI:
10.7717/peerj.13965/table-1
DOI:
10.7717/peerj.13965/table-2
DOI:
10.7717/peerj.13965/table-3
DOI:
10.7717/peerj.13965/supp-1
Language:
English
Publisher:
PeerJ
Publication Date:
2022
detail.hit.zdb_id:
2703241-3
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