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  • 1
    Online Resource
    Online Resource
    Profiling the human immune response to Mycobacterium tuberculosis by human cytokine array
    Elsevier BV ; 2016
    In:  Tuberculosis Vol. 97 ( 2016-03), p. 108-117
    Details
    In: Tuberculosis, Elsevier BV, Vol. 97 ( 2016-03), p. 108-117
    Type of Medium: Online Resource
    ISSN: 1472-9792
    URL: Article
    DOI: 10.1016/j.tube.2015.12.007
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2016
    detail.hit.zdb_id: 2058561-5
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  • 2
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    A Review on the Humic Substances in Pelletizing Binders: Preparation, Interaction Mechanism, and Process Characteristics
    Iron and Steel Institute of Japan ; 2023
    In:  ISIJ International Vol. 63, No. 2 ( 2023-2-15), p. 205-215
    Details
    In: ISIJ International, Iron and Steel Institute of Japan, Vol. 63, No. 2 ( 2023-2-15), p. 205-215
    Type of Medium: Online Resource
    ISSN: 0915-1559 , 1347-5460
    URL: Article
    DOI: 10.2355/isijinternational.ISIJINT-2022-306
    Language: English
    Publisher: Iron and Steel Institute of Japan
    Publication Date: 2023
    detail.hit.zdb_id: 2097795-5
    SSG: 19,1
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  • 3
    Online Resource
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    Numerical simulation of the runner blade channel vortex in Francis turbine
    IOP Publishing ; 2022
    In:  IOP Conference Series: Earth and Environmental Science Vol. 1037, No. 1 ( 2022-06-01), p. 012047-
    Details
    In: IOP Conference Series: Earth and Environmental Science, IOP Publishing, Vol. 1037, No. 1 ( 2022-06-01), p. 012047-
    Abstract: The runner blade channel vortex could induce cavitation erosion, noise and vibration, when Francis turbines operate at part load condition. It's usually difficult to simulate the channel vortex exactly in runner passage, this paper attempts to predict the runner channel vortex in some operating conditions with different discharge and speed factors.The results show that the structure and intensity of runner channel vortex are various between the vortex incipient and development line. The velocity distribution indicates that there is a relationship between the channel vortex and backflow region near the hub with different specific discharge factors, while the flow incident angle has a distinct variation with different specific speed factors. Furthermore, this work enables the researchers to understand the flow field and carry out optimization design in runner hydraulic research.
    Type of Medium: Online Resource
    ISSN: 1755-1307 , 1755-1315
    URL: Article
    DOI: 10.1088/1755-1315/1037/1/012047
    Language: Unknown
    Publisher: IOP Publishing
    Publication Date: 2022
    detail.hit.zdb_id: 2434538-6
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  • 4
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    DataSheet_1.docx
    Frontiers Media SA ; 2022
    In:  Frontiers in Oncology Vol. 12 ( 2022-3-24)
    Details
    In: Frontiers in Oncology, Frontiers Media SA, Vol. 12 ( 2022-3-24)
    Abstract: Hepatocellular carcinoma (HCC) is the most common and deadly type of liver cancer. Autophagy is the process of transporting damaged or aging cellular components into lysosomes for digestion and degradation. Accumulating evidence implies that autophagy is a key factor in tumor progression. The aim of this study was to determine a panel of novel autophagy-related prognostic markers for liver cancer. Methods We conducted a comprehensive analysis of autophagy-related gene (ARG) expression profiles and corresponding clinical information based on The Cancer Genome Atlas (TCGA) and International Cancer Genome Consortium (ICGC) databases. The univariate Cox proportional regression model was used to screen candidate autophagy-related prognostic genes. In addition, a multivariate Cox proportional regression model was used to identify five key prognostic autophagy-related genes (ATIC, BAX, BIRC5, CAPNS1, and FKBP1A), which were used to construct a prognostic signature. Real-time qPCR analysis was used to evaluate the expression levels of ARGs in 20 surgically resected HCC samples and matched tumor-adjacent normal tissue samples. In addition, the effect of FKBP1A on autophagy and tumor progression was determined by performing in vitro and in vivo experiments. Results Based on the prognostic signature, patients with liver cancer were significantly divided into high-risk and low-risk groups in terms of overall survival (OS). A subsequent multivariate Cox regression analysis indicated that the prognostic signature remained an independent prognostic factor for OS. The prognostic signature possessing a better area under the curve (AUC) displayed better performance in predicting the survival of patients with HCC than other clinical parameters. Furthermore, FKBP1A was overexpressed in HCC tissues, and knockdown of FKBP1A impaired cell proliferation, migration, and invasion through the PI3K/AKT/mTOR signaling pathway. Conclusion This study provides a prospective biomarker for monitoring outcomes of patients with HCC.
    Type of Medium: Online Resource
    ISSN: 2234-943X
    URL: Article
    URL: Article
    DOI: 10.3389/fonc.2022.654449
    DOI: 10.3389/fonc.2022.654449.s001
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2022
    detail.hit.zdb_id: 2649216-7
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  • 5
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    Inhibition of vascular endothelial growth factor alleviates neovascular retinopathy with regulated neurotrophic/proinflammatory cytokines through the modulation of DBI‐TSPO signaling
    Wiley ; 2022
    In:  The FASEB Journal Vol. 36, No. 7 ( 2022-07)
    Details
    In: The FASEB Journal, Wiley, Vol. 36, No. 7 ( 2022-07)
    Abstract: Diazepam binding inhibitor (DBI)‐translocator protein (18kDa) (TSPO) signaling in the retina was reported to possess coordinated macroglia‐microglia interactions. We investigated DBI‐TSPO signaling and its correlation with vascular endothelial growth factor (VEGF), neurotrophic or inflammatory cytokines in neovascular retinopathy, and under hypoxic conditions. The vitreous expression of DBI, VEGF, nerve growth factor (NGF), and interleukin‐1beta (IL‐1β) were examined in proliferative diabetic retinopathy (PDR) patients with or without anti‐VEGF therapy and nondiabetic controls. Retinal DBI‐TSPO signaling and the effect of the anti‐VEGF agent were evaluated in a mouse model of oxygen‐induced retinopathy (OIR). Interactions between Müller cell‐derived VEGF and DBI, as well as cocultured microglial cells under hypoxic conditions, were studied, using Western blot, real‐time RT‐PCR, enzyme‐linked immunosorbent assay (ELISA), flow cytometry, and immunofluorescent labeling. Results showed that vitreous levels of DBI, VEGF, NGF, and IL‐1β were significantly higher in PDR patients compared with controls, which further changed after anti‐VEGF therapy. A statistical association was found between vitreous DBI and VEGF, NGF, IL‐1β, and age. The application of the anti‐VEGF agent in the OIR model induced retinal expression of DBI and NGF, and attenuated inflammation and microglial cell activation. Inhibition of Müller cell‐derived VEGF could increase its DBI expression under hypoxic conditions, while the DBI‐TSPO signaling pathway is essential for anti‐VEGF agents exerting anti‐inflammatory and neuroprotective effects, as well as limiting inflammatory magnitude, promoting its neurotrophin production and anti‐inflammatory (M2) polarization in microglial cells. These findings suggest the beneficial effect of anti‐VEGF therapy on inflammation and neurotrophy of retinal glial cells through modulation of the DBI‐TSPO signaling pathway.
    Type of Medium: Online Resource
    ISSN: 0892-6638 , 1530-6860
    URL: Issue
    URL: Article
    DOI: 10.1096/fsb2.v36.7
    DOI: 10.1096/fj.202101294RRR
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 1468876-1
    SSG: 12
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  • 6
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    Expression patterns of nitrate, phosphate, and sulfate transporters in Arabidopsis roots exposed to different nutritional regimes
    Canadian Science Publishing ; 2011
    In:  Botany Vol. 89, No. 9 ( 2011-09), p. 647-653
    Details
    In: Botany, Canadian Science Publishing, Vol. 89, No. 9 ( 2011-09), p. 647-653
    Abstract: Nitrate transporter AtNRT2.1 is the key component of the inducible high-affinity nitrate transport system in Arabidopsis thaliana . AtNRT2.1 is primarily expressed in roots and known to be mainly involved under fluctuating nitrogen supply conditions. It is still unknown whether AtNRT2.1 is involved in plant responses to other nutrient fluctuations. In this study, we found that the expression of AtNRT2.1 was also upregulated by phosphate and sulfate resupply, which may indicate a novel role in regulating phosphate and sulfate responses. Our study also demonstrated that expression of the major Pi transporter (Pht1) family member, AtPHT1;2, was suppressed by nitrate starvation and induced by nitrate resupply and sulfate starvation in comparison to the continuous nutrient treatment. Moreover, this study also showed that expression of sulfur transporter SULTR1;1 and AtNRT2.1 was suppressed by complete nutrient starvation and induced by complete nutrient resupply. These novel results provide strong evidence that there is crosstalk among the nitrate, sulfate, and phosphate transporters in regulating different nutrient fluctuations in Arabidopsis roots.
    Type of Medium: Online Resource
    ISSN: 1916-2790 , 1916-2804
    URL: Article
    DOI: 10.1139/b11-053
    Language: English
    Publisher: Canadian Science Publishing
    Publication Date: 2011
    detail.hit.zdb_id: 2467208-7
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  • 7
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    ADMM-Based Coordination of Electric Vehicles in Constrained Distribution Networks Considering Fast Charging and Degradation
    Institute of Electrical and Electronics Engineers (IEEE) ; 2021
    In:  IEEE Transactions on Intelligent Transportation Systems Vol. 22, No. 1 ( 2021-1), p. 565-578
    Details
    In: IEEE Transactions on Intelligent Transportation Systems, Institute of Electrical and Electronics Engineers (IEEE), Vol. 22, No. 1 ( 2021-1), p. 565-578
    Type of Medium: Online Resource
    ISSN: 1524-9050 , 1558-0016
    URL: Journal
    URL: Article
    DOI: 10.1109/TITS.6979
    DOI: 10.1109/TITS.2020.3015122
    Language: Unknown
    Publisher: Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2021
    detail.hit.zdb_id: 2034300-0
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  • 8
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    Comparative Evaluation of the Phytochemical Profiles and Antioxidant Potentials of Olive Leaves from 32 Cultivars Grown in China
    MDPI AG ; 2022
    In:  Molecules Vol. 27, No. 4 ( 2022-02-15), p. 1292-
    Details
    In: Molecules, MDPI AG, Vol. 27, No. 4 ( 2022-02-15), p. 1292-
    Abstract: Olives (Olea europaea L.) are a significant part of the agroindustry in China. Olive leaves, the most abundant by-products of the olive and olive oil industry, contain bioactive compounds that are beneficial to human health. The purpose of this study was to evaluate the phytochemical profiles and antioxidant capacities of olive leaves from 32 cultivars grown in China. A total of 32 phytochemical compounds were identified using high-performance liquid chromatography–electrospray ionization–tandem mass spectrometry, including 17 flavonoids, five iridoids, two hydroxycinnamic acids, six triterpenic acids, one simple phenol, and one coumarin. Specifically, olive leaves were found to be excellent sources of flavonoids (4.92–18.29 mg/g dw), iridoids (5.75–33.73 mg/g dw), and triterpenic acids (15.72–35.75 mg/g dw), and considerable variations in phytochemical content were detected among the different cultivars. All tested cultivars were classified into three categories according to their oil contents for further comparative phytochemicals assessment. Principal component analysis indicated that the investigated olive cultivars could be distinguished based upon their phytochemical profiles and antioxidant capacities. The olive leaves obtained from the low-oil-content ( 〈 16%) cultivars exhibited higher levels of glycosylated flavonoids and iridoids, while those obtained from high-oil-content ( 〉 20%) cultivars contained mainly triterpenic acids in their compositions. Correspondingly, the low-oil-content cultivars (OL3, Frantoio selection and OL14, Huaou 5) exhibited the highest ABTS antioxidant activities (758.01 ± 16.54 and 710.64 ± 14.58 mg TE/g dw, respectively), and OL9 (Olea europaea subsp. Cuspidata isolate Yunnan) and OL3 exhibited the highest ferric reducing/antioxidant power assay values (1228.29 ± 23.95 mg TE/g dw and 1099.99 ± 14.30 mg TE/g dw, respectively). The results from this study may be beneficial to the comprehensive evaluation and utilization of bioactive compounds in olive leaves.
    Type of Medium: Online Resource
    ISSN: 1420-3049
    URL: Article
    DOI: 10.3390/molecules27041292
    Language: English
    Publisher: MDPI AG
    Publication Date: 2022
    detail.hit.zdb_id: 2008644-1
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  • 9
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    Quantitative Analysis of Flavonoids in Fruiting Bodies of Sanghuangporus Using Ultra-High-Performance Liquid Chromatography Coupled with Triple Quadrupole Mass Spectrometry
    MDPI AG ; 2023
    In:  Molecules Vol. 28, No. 13 ( 2023-07-02), p. 5166-
    Details
    In: Molecules, MDPI AG, Vol. 28, No. 13 ( 2023-07-02), p. 5166-
    Abstract: A rapid, precise, and dependable method for quantifying flavonoids in the fruiting bodies of Sanghuangporus was established using ultra-high-performance liquid chromatography coupled with triple quadrupole mass spectrometry (UHPLC-QQQ-MS/MS). Separation was achieved using a ZORBAX Eclipse Plus C18 column (1.8 μm, 3.0 mm × 100 mm) with a 15 min gradient of a mobile phase consisting of 0.01% aqueous formic acid and 2 mm/L ammonium formate (mobile phase A), and 0.01% formic acid and 2 mm/L ammonium formate in methanol (mobile phase B). A mass spectrometry analysis was performed using the multiple reaction monitoring (MRM) mode with an electrospray ion source. This method enabled the simultaneous detection of 10 flavonoids (sakuranetin, quercitrin, myricitrin, kaempferol, luteolin, rutin, hyperoside, kaempferol-3-O-rutinoside, catechin, and catechin gallate) in the fruiting bodies of Sanghuangporus. Additionally, we applied this method to analyze the flavonoid content in fruiting bodies of various Sanghuangporus species. The results revealed substantial variations in flavonoid content, up to a 100-fold difference, among different species, with myricitrin, hyperoside, and rutin identified as the most abundant flavonoids. This protocol serves as a valuable tool for quantifying flavonoid compounds in different Sanghuangporus species or under diverse cultivation conditions, particularly for identifying species with high levels of specific flavonoid compounds.
    Type of Medium: Online Resource
    ISSN: 1420-3049
    URL: Article
    DOI: 10.3390/molecules28135166
    Language: English
    Publisher: MDPI AG
    Publication Date: 2023
    detail.hit.zdb_id: 2008644-1
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  • 10
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    Table_2.XLSX
    Frontiers Media SA ; 2022
    In:  Frontiers in Plant Science Vol. 13 ( 2022-6-2)
    Details
    In: Frontiers in Plant Science, Frontiers Media SA, Vol. 13 ( 2022-6-2)
    Abstract: Enhancing oil content is one of the major goals in Brassica napus breeding; however, genetic regulation of seed oil content in plants is complex and not fully elucidated. In this study, we report proteins that were differentially accumulated in immature seeds of 35 days after anthesis between two recombinant inbred lines with contrasting seed oil content, high oil content line (HOCL) and low oil content line (LOCL) using a multiplex isobaric tandem mass tags (TMT)-based quantitative proteomic approach. Over 4,600 proteins were quantified in seeds of the two lines, and 342 proteins showed differential accumulation between seeds of HOCL and LOCL. Gene Ontology enrichment analysis revealed that the differentially accumulated proteins were enriched in proteins involved in lipid biosynthesis and metabolism, photosynthesis, and nutrient reservoir activity. Western blot confirmed the increased abundance of a late embryogenesis abundant protein (BnLEA57) in HOCL seeds compared with LOCL seeds, and overexpression of either BnLEA57 gene or its homology BnLEA55 in transgenic Arabidopsis thaliana enhanced oil content in Arabidopsis seeds. Our work provides new insights into the molecular regulatory mechanism of seed oil content in B. napus .
    Type of Medium: Online Resource
    ISSN: 1664-462X
    URL: Article
    URL: Article
    URL: Article
    URL: Article
    DOI: 10.3389/fpls.2022.907244
    DOI: 10.3389/fpls.2022.907244.s001
    DOI: 10.3389/fpls.2022.907244.s002
    DOI: 10.3389/fpls.2022.907244.s003
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2022
    detail.hit.zdb_id: 2687947-5
    detail.hit.zdb_id: 2613694-6
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