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  • 1
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    The prevalence of mild cognitive impairment and its etiological subtypes in elderly Chinese
    Wiley ; 2014
    In:  Alzheimer's & Dementia Vol. 10, No. 4 ( 2014-07), p. 439-447
    Details
    In: Alzheimer's & Dementia, Wiley, Vol. 10, No. 4 ( 2014-07), p. 439-447
    Abstract: Epidemiologic studies on mild cognitive impairment (MCI) are limited in China. Methods Using a multistage cluster sampling design, a total of 10,276 community residents (6096 urban, 4180 rural) aged 65 years or older were evaluated and diagnosed with normal cognition, MCI, or dementia. MCI was further categorized by imaging into MCI caused by prodromal Alzheimer's disease (MCI‐A), MCI resulting from cerebrovascular disease (MCI‐CVD), MCI with vascular risk factors (MCI‐VRF), and MCI caused by other diseases (MCI‐O). Results The prevalences of overall MCI, MCI‐A, MCI‐CVD, MCI‐VRF, and MCI‐O were 20.8% (95% confidence interval [CI] = 20.0–21.6%), 6.1% (95% CI = 5.7–6.6%), 3.8% (95% CI = 3.4–4.2%), 4.9% (95% CI = 4.5–5.4%), and 5.9% (95% CI = 5.5–6.4%) respectively. The rural population had a higher prevalence of overall MCI (23.4% vs 16.8%, P   〈  .001). Conclusions The prevalence of MCI in elderly Chinese is higher in rural than in urban areas. Vascular‐related MCI (MCI‐CVD and MCI‐VRF) was most common.
    Type of Medium: Online Resource
    ISSN: 1552-5260 , 1552-5279
    URL: Article
    DOI: 10.1016/j.jalz.2013.09.008
    Language: English
    Publisher: Wiley
    Publication Date: 2014
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    detail.hit.zdb_id: 2201940-6
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  • 2
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    Bisphenol A promotes breast cancer cell proliferation by driving miR-381-3p-PTTG1-dependent cell cycle progression
    Elsevier BV ; 2021
    In:  Chemosphere Vol. 268 ( 2021-04), p. 129221-
    Details
    In: Chemosphere, Elsevier BV, Vol. 268 ( 2021-04), p. 129221-
    Type of Medium: Online Resource
    ISSN: 0045-6535
    URL: Article
    DOI: 10.1016/j.chemosphere.2020.129221
    RVK:
    AR 10100
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2021
    detail.hit.zdb_id: 120089-6
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  • 3
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    The prevalence of dementia in urban and rural areas of China
    Wiley ; 2014
    In:  Alzheimer's & Dementia Vol. 10, No. 1 ( 2014-01), p. 1-9
    Details
    In: Alzheimer's & Dementia, Wiley, Vol. 10, No. 1 ( 2014-01), p. 1-9
    Abstract: The Chinese population has been aging rapidly and the country's economy has experienced exponential growth during the past three decades. The goal of this study was to estimate the changes in the prevalence of dementia, Alzheimer's disease (AD), and vascular dementia (VaD) among elderly Chinese individuals and to analyze differences between urban and rural areas. Methods For the years 2008 to 2009, we performed a population‐based cross‐sectional survey with a multistage cluster sampling design. Residents aged 65 years and older were drawn from 30 urban (n = 6096) and 45 rural (n = 4180) communities across China. Participants were assessed with a series of clinical examinations and neuropsychological measures. Dementia, AD, and VaD were diagnosed according to established criteria via standard diagnostic procedures. Results The prevalence of dementia, AD, and VaD among individuals aged 65 years and older were 5.14% (95% CI, 4.71–5.57), 3.21% (95% CI, 2.87–3.55), and 1.50% (95% CI, 1.26–1.74), respectively. The prevalence of dementia was significantly higher in rural areas than in urban ones (6.05% vs. 4.40%, P 〈 .001). The same regional difference was also seen for AD (4.25% vs. 2.44%, P 〈 .001) but not for VaD (1.28% vs. 1.61%, P = .166). The difference in AD was not evident when the sample was stratified by educational level. Moreover, the risk factors for AD and VaD differed for urban and rural populations. Conclusions A notably higher prevalence of dementia and AD was found in rural areas than in urban ones, and education might be an important reason for the urban–rural differences.
    Type of Medium: Online Resource
    ISSN: 1552-5260 , 1552-5279
    URL: Article
    DOI: 10.1016/j.jalz.2013.01.012
    Language: English
    Publisher: Wiley
    Publication Date: 2014
    detail.hit.zdb_id: 2211627-8
    detail.hit.zdb_id: 2201940-6
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  • 4
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    Injectable exosome-functionalized extracellular matrix hydrogel for metabolism balance and pyroptosis regulation in intervertebral disc degeneration
    Springer Science and Business Media LLC ; 2021
    In:  Journal of Nanobiotechnology Vol. 19, No. 1 ( 2021-12)
    Details
    In: Journal of Nanobiotechnology, Springer Science and Business Media LLC, Vol. 19, No. 1 ( 2021-12)
    Abstract: Exosome therapy is a promising therapeutic approach for intervertebral disc degeneration (IVDD) and achieves its therapeutic effects by regulating metabolic disorders, the microenvironment and cell homeostasis with the sustained release of microRNAs, proteins, and transcription factors. However, the rapid clearance and disruption of exosomes are the two major challenges for the application of exosome therapy in IVDD. Herein, a thermosensitive acellular extracellular matrix (ECM) hydrogel coupled with adipose-derived mesenchymal stem cell (ADSC) exosomes (dECM@exo) that inherits the superior properties of nucleus pulposus tissue and ADSCs was fabricated to ameliorate IVDD. This thermosensitive dECM@exo hydrogel system can provide not only in situ gelation to replenish ECM leakage in nucleus pulposus cells (NPCs) but also an environment for the growth of NPCs. In addition, sustained release of ADSC-derived exosomes from this system regulates matrix synthesis and degradation by regulating matrix metalloproteinases (MMPs) and inhibits pyroptosis by mitigating the inflammatory response in vitro. Animal results demonstrated that the dECM@exo hydrogel system maintained early IVD microenvironment homeostasis and ameliorated IVDD. This functional system can serve as a powerful platform for IVD drug delivery and biotherapy and an alternative therapy for IVDD.
    Type of Medium: Online Resource
    ISSN: 1477-3155
    URL: Article
    DOI: 10.1186/s12951-021-00991-5
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2021
    detail.hit.zdb_id: 2100022-0
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  • 5
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    Hot Compression Deformation and Activation Energy of Nanohybrid-Reinforced AZ80 Magnesium Matrix Composite
    MDPI AG ; 2020
    In:  Metals Vol. 10, No. 1 ( 2020-01-13), p. 119-
    Details
    In: Metals, MDPI AG, Vol. 10, No. 1 ( 2020-01-13), p. 119-
    Abstract: The hot deformation test of the nano silicon carbide (nano-SiC) and carbon nano tubes (CNT) hybrid-reinforced AZ80 matrix composite was performed at compression temperatures of 300–450 °C and strain rates of 0.0001–1 s−1. It could be observed that the flow stress of the nanocomposite rose with the reduction of deformation temperature and the increase of strain rate. The hot deformation behaviors of the composite could be described by the sine-hyperbolic Arrhenius equation, and deformation activation energy (Q) was calculated to be 157.8 kJ/mol. The Q values of the extruded nanohybrid/AZ80 composite in this study and other similar studies on extruded AZ80 alloys were compared in order to analyze the effect of the addition of reinforcement, and the effects of deformation conditions on activation energy were analyzed. Finally, the compression microstructure in an unstable condition was carefully analyzed, and results indicated that the phenomenon of local instability was easy to occur at the compression specimen of the nanohybrid/AZ80 composite under deformation conditions of low temperature with high strain rate (300 °C, 0.1–0.01 s−1), and high temperature with low strain rate (450 °C, 0.0001 s−1).
    Type of Medium: Online Resource
    ISSN: 2075-4701
    URL: Article
    DOI: 10.3390/met10010119
    Language: English
    Publisher: MDPI AG
    Publication Date: 2020
    detail.hit.zdb_id: 2662252-X
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  • 6
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    Diversity and spatiotemporal dynamics of fungal communities in the rhizosphere soil of Lycium barbarum L.: a new insight into the mechanism of geoherb formation
    Springer Science and Business Media LLC ; 2022
    In:  Archives of Microbiology Vol. 204, No. 3 ( 2022-03)
    Details
    In: Archives of Microbiology, Springer Science and Business Media LLC, Vol. 204, No. 3 ( 2022-03)
    Abstract: Lycium barbarum L. is a well-known traditional geoherb in Ningxia, China. The fruits of L. barbarum contain several dietary constituents, and thus, they exert many beneficial effects on human health. However, a few studies have been conducted on the geoherb L. barbarum and its rhizosphere soil fungal community. In this study, we determined the physicochemical properties and fungal community structure of rhizosphere soil of L. barbarum from three regions of China, namely Ningxia (NX), Qinghai (QH), and Xinjiang (XJ), during three development stages of L. barbarum . Soil pH varied between 7.56 and 8.60 across the three regions, indicating that alkaline soil is conducive to the growth of L. barbarum . The majority of soil properties in NX, an authentic geoherb-producing area, were substantially inferior to those in XJ and QH during all three developmental stages. Total sugar, polysaccharide (LBP), and flavonoid contents were the highest in wolfberry fruits from NX. High-throughput sequencing showed that the abundance of the soil fungal population in NX was higher than that in QH and XJ during the flowering and fruiting stage and summer dormant stage. Moreover, the soil fungal diversity increased with the development of wolfberry. Ascomycota and Mortierellomycota were the predominant phyla in the rhizosphere fungal communities in all samples. Redundancy analysis showed a significant correlation of the soil-available phosphorus and LBP of wolfberry fruits with the fungal community composition. The characteristics of rhizosphere fungal communities determined in the present study provide insights into the mechanism of geoherb formation in NX wolfberry.
    Type of Medium: Online Resource
    ISSN: 0302-8933 , 1432-072X
    URL: Article
    DOI: 10.1007/s00203-022-02781-5
    RVK:
    WA 15000
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2022
    detail.hit.zdb_id: 1458451-7
    detail.hit.zdb_id: 124824-8
    SSG: 12
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  • 7
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    Collaborative content dissemination based on game theory in multimedia cloud
    Elsevier BV ; 2017
    In:  Knowledge-Based Systems Vol. 124 ( 2017-05), p. 1-15
    Details
    In: Knowledge-Based Systems, Elsevier BV, Vol. 124 ( 2017-05), p. 1-15
    Type of Medium: Online Resource
    ISSN: 0950-7051
    URL: Article
    DOI: 10.1016/j.knosys.2017.02.026
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2017
    detail.hit.zdb_id: 58029-6
    SSG: 24,1
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  • 8
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    Combining texture features of whole slide images improves prognostic prediction of recurrence-free survival for cutaneous melanoma patients
    Springer Science and Business Media LLC ; 2020
    In:  World Journal of Surgical Oncology Vol. 18, No. 1 ( 2020-12)
    Details
    In: World Journal of Surgical Oncology, Springer Science and Business Media LLC, Vol. 18, No. 1 ( 2020-12)
    Abstract: Accurate prediction of recurrence-free survival (RFS) is important for the prognosis of cutaneous melanoma patients. The image-based pathological examination remains as the gold standard for diagnosis. It is of clinical interest to account for computer-aided processing of pathology image when performing prognostic analysis. Methods We enrolled in this study a total of 152 patients from TCGA-SKCM (The Cancer Genome Atlas Skin Cutaneous Melanoma project) with complete information in recurrence-related survival time, baseline variables (clinicopathologic variables, mutation status of BRAF and NRAS genes), gene expression data, and whole slide image (WSI) features. We preprocessed WSI to segment global or nucleus areas, and extracted 3 types of texture features from each region. We performed cross validation and used multiple evaluation metrics including C-index and time-dependent AUC to determine the best model of predicting recurrence events. We further performed differential gene expression analysis between the higher and lower-risk groups within AJCC pathologic tumor stage III patients to explore the underlying molecular mechanisms driving risk stratification. Results The model combining baseline variables and WSI features had the best performance among models with any other types of data integration. The prognostic risk score generated by this model could provide a higher-resolution risk stratification within pathologically defined subgroups. We found the selected image features captured important immune-related variations, such as the aberration of expression in T cell activation and proliferation gene sets, and therefore contributed to the improved prediction. Conclusions Our study provided a prognostic model based on the combination of baseline variables and computer-processed WSI features. This model provided more accurate prediction than models based on other types of data combination in recurrence-free survival analysis. Trial registration This study was based on public open data from TCGA and hence the study objects were retrospectively registered.
    Type of Medium: Online Resource
    ISSN: 1477-7819
    URL: Article
    DOI: 10.1186/s12957-020-01909-5
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2020
    detail.hit.zdb_id: 2118383-1
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  • 9
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    A purified fraction of polysaccharides from the fruits of Lycium barbarum L. improves glucose homeostasis and intestinal barrier function in high-fat diet-fed mice
    Royal Society of Chemistry (RSC) ; 2023
    In:  Food & Function Vol. 14, No. 11 ( 2023), p. 5311-5325
    Details
    In: Food & Function, Royal Society of Chemistry (RSC), Vol. 14, No. 11 ( 2023), p. 5311-5325
    Abstract: High-fat diet (HFD) consumption can induce intestinal barrier dysfunction and disrupt glucose metabolism. Our previous studies have demonstrated that polysaccharides obtained from the fruits of Lycium barbarum L. (LBPs) could suppress acute experimental diabetes as well as colitis in mice. In the present study, the modulating effects of a purified fraction of LBPs, named LBPs-4, on glucose homeostasis and intestinal barrier function in mice fed with a HFD were investigated. Our results indicated that the oral administration of LBP-4 (200 mg per kg per day) improved hyperglycemia, glucose intolerance, insulin resistance and islet β-cell hyperplasia in HFD-fed mice. Moreover, LBPs-4 intervention enhanced the intestinal barrier integrity by increasing the expression levels of zonula occludens 1 and claudin-1 and the number of goblet cells in the colon. LBPs-4 also modulated the composition of gut microbiota by increasing the relative abundances of butyrate producer Allobaculum and acetate producer Romboutsia . The results of fecal transplantation experiments, transferring of microbiota from LBPs-4-fed donor mice to HFD-fed recipient mice, validated the cause-effect relationship between LBPs-4-evoked changes in the gut microbiota and improvement of glucose homeostasis and intestinal barrier function. Collectively, these findings suggested that LBPs-4 might be developed as promising prebiotics to improve glucose metabolism and gut health.
    Type of Medium: Online Resource
    ISSN: 2042-6496 , 2042-650X
    URL: Article
    DOI: 10.1039/D3FO00262D
    Language: English
    Publisher: Royal Society of Chemistry (RSC)
    Publication Date: 2023
    detail.hit.zdb_id: 2612033-1
    detail.hit.zdb_id: 2578152-2
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  • 10
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    Modulation of gut microbiota and hypoglycemic/hypolipidemic activity of flavonoids from the fruits of Lycium barbarum on high-fat diet/streptozotocin-induced type 2 diabetic mice
    Royal Society of Chemistry (RSC) ; 2022
    In:  Food & Function Vol. 13, No. 21 ( 2022), p. 11169-11184
    Details
    In: Food & Function, Royal Society of Chemistry (RSC), Vol. 13, No. 21 ( 2022), p. 11169-11184
    Abstract: Lycium barbarum has been used as a traditional medicinal and edible plant in China. The fruits of L. barbarum , rich in flavonoids with large exploration potential, are associated with antioxidant and anti-inflammatory activities that may contribute to reducing the risk of diabetes. However, information on the antidiabetic activity of flavonoids from L. barbarum (LBFs) is still limited. In this study, therefore, the effects of LBFs on the high-fat diet (HFD)/streptozotocin (STZ)-induced type 2 diabetes (T2DM) mice were investigated. LBFs showed significant anti-diabetic activity, as evidenced by the recovery of various physical signs (body weight and the level of GLP-1 were increased and water consumption, liver index, fasting blood glucose, HOMA-IR, HOMA-IS, levels of HbA1c, and OGTT were decreased), improving the function of glucose and lipid metabolism (levels of TC and TG in the serum and liver were decreased, mRNA expression of GK, PFK and PPARα were increased, and mRNA expression of G6Pase, PEPCK, PPARγ, FAS, ACC, and SREBP-1c were inhibited), reduction of the expression of proinflammatory cytokines and related mRNA (such as LPS, TLR-4, TNF-α, IL-6, IL-10, and IFN-γ), and restoration of liver tissue structure (characterized with reduction of fat vesicles, remission of hepatocyte swelling, and orderly arrangement of hepatic cords). Moreover, the modulation of gut microbiota of HFD/STZ-induced T2DM mice was explored. The results showed that Bacteroidales_S24-7_group, Lachnospiraceae, Ruminococcaceae, Clostridiales_vadinBB60_group, Allobaculum , Turicibacter , Coriobacteriaeceae and Enterococcus were the dominant bacteria associated with T2DM. In conclusion, LBFs ameliorated HFD/STZ-induced T2DM in mice through three targets, including improving glucose and lipid metabolism, blocking pro-inflammatory cytokines, and regulating gut microbiota, except that the optimal dose of LBFs needs to be further explored.
    Type of Medium: Online Resource
    ISSN: 2042-6496 , 2042-650X
    URL: Article
    DOI: 10.1039/D2FO01268E
    Language: English
    Publisher: Royal Society of Chemistry (RSC)
    Publication Date: 2022
    detail.hit.zdb_id: 2612033-1
    detail.hit.zdb_id: 2578152-2
    SSG: 21
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