In:
Frontiers in Microbiology, Frontiers Media SA, Vol. 15 ( 2024-4-26)
Abstract:
Porcine reproductive and respiratory syndrome virus (PRRSV) poses widespread epidemics in swine herds, yet the drivers underlying lineage replacements/fitness dynamics remain unclear. To delineate the evolutionary trajectories of PRRSV-2 lineages prevalent in China, we performed a comprehensive longitudinal phylodynamic analysis of 822 viral sequences spanning 1991–2022. The objectives encompassed evaluating lineage dynamics, genetic diversity, recombination patterns and glycosylation profiles. A significant shift in the dominance of PRRSV-2 sub-lineages has been observed over the past 3 decades, transitioning from sub-lineage 8.7 to sub-lineage 1.8, followed by extensive diversification. The analysis revealed discordant recombination patterns between the two dominant viral sub-lineages 1.8 and 8.7, underscoring that modular genetic exchanges contribute significantly to their evolutionary shaping. Additionally, a strong association was found between recombination breakpoint locations and transcriptional regulatory sequences (TRSs). Glycosylation patterns also demonstrated considerable variability across sub-lineages and temporally, providing evidence for immune-driven viral evolution. Furthermore, we quantified different evolutionary rates across sub-lineages, with sub-lineage 1.8 uniquely displaying the highest nucleotide substitution rates. Taken together, these findings provide refined insight into the evolutionary mechanisms underpinning cyclic shifts in dominance among regionally circulating PRRSV sub-lineages.
Type of Medium:
Online Resource
ISSN:
1664-302X
DOI:
10.3389/fmicb.2024.1398470
DOI:
10.3389/fmicb.2024.1398470.s001
DOI:
10.3389/fmicb.2024.1398470.s002
DOI:
10.3389/fmicb.2024.1398470.s003
DOI:
10.3389/fmicb.2024.1398470.s004
DOI:
10.3389/fmicb.2024.1398470.s005
DOI:
10.3389/fmicb.2024.1398470.s006
DOI:
10.3389/fmicb.2024.1398470.s007
DOI:
10.3389/fmicb.2024.1398470.s008
DOI:
10.3389/fmicb.2024.1398470.s009
DOI:
10.3389/fmicb.2024.1398470.s010
DOI:
10.3389/fmicb.2024.1398470.s011
Language:
Unknown
Publisher:
Frontiers Media SA
Publication Date:
2024
detail.hit.zdb_id:
2587354-4
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