In:
Spectroscopy, Hindawi Limited, Vol. 26, No. 3 ( 2011), p. 179-185
Abstract:
Tetra-tert-butyl zinc(II) phthalocyanine has attracted great attention as an effective photosensitizer in the field of photodynamic therapy. However, tetra-tert-butyl zinc(II) phthalocyanine is hydrophobic and trends to aggregate to form the inactive congeries in aqueous solution, which dramatically reduce its photodynamic activity. To solve this problem, tetra-tert-butyl zinc(II) phthalocyanine was encapsulated into silica nanoparticles using microemulsion method and its properties were studied using spectroscopic methods. After embedded inside the silica nanoparticles, the water-solubility, stability and monomer percent of phthalocyanine in water were greatly improved comparing with the free phthalocyanines, and therefore, its photo-induced singlet oxygen generation efficacy of drug-doped silica nanoparticles was improved. The results indicated that encapsulation hydrophobic phthalocyanine into silica nanoparticles was an effective way to solve their problems and promote their clinical application.
Type of Medium:
Online Resource
ISSN:
0712-4813
,
1875-922X
Language:
English
Publisher:
Hindawi Limited
Publication Date:
2011
detail.hit.zdb_id:
2068433-2
SSG:
11
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