In:
Synlett, Georg Thieme Verlag KG, Vol. 32, No. 14 ( 2021-09), p. 1437-1446
Kurzfassung:
In this work, we introduced a multifunctional Ag(I)/CAAA-amidphos complex catalyzed asymmetric 1,3-dipolar cycloaddition of acrylates with α-imino esters, affording a series of 2,4,5-trisubstituted endo-pyrrolidines in good yields (up to 97%) with high enantioselectivities (up to 98% ee). Meanwhile, the catalytic system was also applied in the three-component one-pot reaction of α-imino esters formed in situ under the action of N,N′-diisopropylcarbodiimide. In addition, the gram-scale reaction was realized for the formal synthesis of (+)-ibophyllidine in eight steps.
Materialart:
Online-Ressource
ISSN:
0936-5214
,
1437-2096
DOI:
10.1055/s-0040-1706053
Sprache:
Englisch
Verlag:
Georg Thieme Verlag KG
Publikationsdatum:
2021
ZDB Id:
2042012-2
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