In:
Nanomedicine, Future Medicine Ltd, Vol. 13, No. 13 ( 2018-07), p. 1517-1533
Abstract:
Aim: To develop precise targeting and versatile Fe 3 O 4 @SiO 2 -P123/PTX-ZnPc nanoparticles (FSP-PTX-ZnPc NPs) to reverse paclitaxel (PTX)-induced multidrug resistance in breast cancer. Materials & methods: PTX and zinc (II) phthalocyanine (ZnPc) co-loaded FSP-PTX-ZnPc NPs were designed. The resulting multifunctional NPs were evaluated systematically in vitro and in vivo, and the mechanism of drug-resistance reversal was investigated. Results: The NPs enhanced drug uptake in MCF-7/PDR cells by increasing drug solubility and impairing P-glycoprotein efflux. Additionally, magnetic targeting and enhanced permeation and retention (EPR) effect enhanced drug accumulation in tumor, facilitating the chemotherapeutic and photodynamic therapy effects. Moreover, FSP-PTX-ZnPc NPs could penetrate the blood–brain barrier, a desirable trait for brain disease therapy. Conclusion: The multifunctional FSP-PTX-ZnPc NPs are an effective tool for overcoming drug resistance in breast cancer.
Type of Medium:
Online Resource
ISSN:
1743-5889
,
1748-6963
DOI:
10.2217/nnm-2017-0393
Language:
English
Publisher:
Future Medicine Ltd
Publication Date:
2018
SSG:
15,3
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