In:
European Journal of Organic Chemistry, Wiley, Vol. 2007, No. 21 ( 2007-07), p. 3520-3525
Abstract:
One‐pot, three‐component condensation reactions of aromatic aldehydes 1 , 3‐methylpyrazol‐5‐one ( 2 ) and ethyl trifluoroacetoacetate ( 3 ) provided an efficient methodology for the preparation of ethyl (4 S *,5 R *)‐4‐aryl‐6‐hydroxy‐3‐methyl‐6‐(trifluoromethyl)‐2,4,5,6‐tetrahydropyrazolo[3,4‐ b ]pyran‐5‐carboxylate derivatives ( 4 ). The reactions gave moderate to good yields under mild conditions. These new products 4 were fully characterized by spectral methods and single‐crystal X‐ray diffraction analysis. A plausible reaction pathway for the formation of 4 is presented. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2007)
Type of Medium:
Online Resource
ISSN:
1434-193X
,
1099-0690
DOI:
10.1002/ejoc.v2007:21
DOI:
10.1002/ejoc.200601055
Language:
English
Publisher:
Wiley
Publication Date:
2007
detail.hit.zdb_id:
1410000-9
detail.hit.zdb_id:
1475010-7
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