In:
Liver International, Wiley, Vol. 35, No. 11 ( 2015-11), p. 2392-2400
Abstract:
Controlled attenuation parameter ( CAP ) is a non‐invasive method for evaluating hepatic steatosis. However, larger skin capsular distance ( SCD ) can affect the accuracy. The aim of this study was to investigate the impact of SCD on the diagnostic performance of CAP and liver stiffness measurement ( LSM ). Methods Of 101 patients with non‐alcoholic fatty liver disease ( NAFLD ) and 280 patients with chronic hepatitis B ( CHB ) who underwent liver biopsy were prospectively recruited. CAP , LSM and SCD were performed using FibroScan with M probe. The areas under receiver operating characteristics curves ( AUROC s) were calculated to determine the diagnostic efficacy. The optimal thresholds were defined by the maximum Youden index. Results SCD (B 30.34, P 〈 0.001) and hepatic steatosis (B 23.04, P 〈 0.001) were independently associated with CAP by multivariate analysis. The AUROC s were slightly higher for SCD 〈 25 mm compared to those for SCD ≥25 mm for steatosis ≥5% (0.88 vs. 0.81), 〉 33% (0.90 vs. 0.85) and 〉 66% (0.84 vs. 0.72). For SCD 〈 25 mm, the optimal CAP cut‐offs for differentiating steatosis ≥5%, 〉 33% and 〉 66% were 255.0 dB /m, 283.5 dB /m and 293.5 dB /m. However, cut‐offs were elevated by approximately 60–70 dB /m for SCD ≥25 mm. When stratified by fibrosis grade, LSM was significantly affected by SCD ≥25 mm for advanced fibrosis (≥F3) in NAFLD , but not in CHB. Conclusion CAP is a promising tool for detecting and quantifying hepatic steatosis. SCD ≥25 mm may cause overestimation of steatosis. Similarly, SCD ≥25 mm affects the detection of advanced fibrosis by LSM in NAFLD patients.
Type of Medium:
Online Resource
ISSN:
1478-3223
,
1478-3231
DOI:
10.1111/liv.2015.35.issue-11
Language:
English
Publisher:
Wiley
Publication Date:
2015
detail.hit.zdb_id:
2124684-1
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