In:
International Journal of Endocrinology, Hindawi Limited, Vol. 2018 ( 2018-07-16), p. 1-10
Abstract:
Aim . This retrospective study is aimed at investigating whether aldosterone-renin ratio (ARR) cutoffs calculated by the plasma aldosterone concentration (PAC)/plasma renin concentration (PRC) should be set differently in patients of different ages. Methods . 521 hypertensive patients were screened for primary aldosteronism (PA) by the PAC/PRC. 174 patients diagnosed with PA and 311 patients with essential hypertension (EH) were included in the final analysis. Subjects were subdivided into four age groups: 〈 40, 40–49, 50–59, and ≥60 years old. Results . The accuracy of the ARR varied greatly among the different age groups. An ARR of 3.7 (ng/dl)/( μ IU/ml) had a sensitivity of 100% and a specificity of 80% in patients ≥ 60 years old. With this cutoff, the sensitivities in patients 〈 40, 40–49, and 50–59 years old were 74%, 82%, and 87%, respectively, and the specificities were 94%, 95%, and 94%, respectively. To achieve a sensitivity higher than 90%, the ARR cutoff needed to be lowered to 2.0 (ng/dl)/( μ IU/ml) for patients 40–49 and 50–59 years old, resulting in sensitivities of 90% and 95%, respectively, and specificities of 80% and 84%, respectively. To achieve a sensitivity higher than 90%, the ARR cutoff needed to be lowered to 1.0 (ng/dl)/( μ IU/ml) for patients 〈 40 years old, resulting in a sensitivity of 90% and a specificity of 82%. Conclusions . An ARR of 3.7 (ng/dl)/( μ IU/ml) is optimal for patients ≥ 60 years; for patients 40–59 years, the optimal ARR cutoff is 2.0; for those younger than 40 years, an ARR of 1.0 may be more reasonable.
Type of Medium:
Online Resource
ISSN:
1687-8337
,
1687-8345
DOI:
10.1155/2018/8647026
Language:
English
Publisher:
Hindawi Limited
Publication Date:
2018
detail.hit.zdb_id:
2502951-4
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