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  • 1
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    Effect of Rivaroxaban vs Enoxaparin on Major Cardiac Adverse Events and Bleeding Risk in the Acute Phase of Acute Coronary Syndrome : The H-REPLACE Randomized Equivalence and Noninferiority Trial
    American Medical Association (AMA) ; 2023
    In:  JAMA Network Open Vol. 6, No. 2 ( 2023-02-10), p. e2255709-
    Details
    In: JAMA Network Open, American Medical Association (AMA), Vol. 6, No. 2 ( 2023-02-10), p. e2255709-
    Abstract: Parenteral enoxaparin is a preferred anticoagulant used in the acute phase for patients with acute coronary syndrome (ACS). The safety and efficacy of short-term low-dose rivaroxaban in this clinical setting remain unknown. Objective To compare the safety and efficacy of rivaroxaban vs enoxaparin in the acute phase of ACS. Design, Setting, and Participants This multicenter, prospective, open-label, active-controlled, equivalence and noninferiority trial was conducted from January 2017 through May 2021 with a 6-month follow-up at 21 hospitals in China. Participants included patients with ACS missing the primary reperfusion window or before selective revascularization. Data were analyzed from November 2021 to November 2022. Interventions Participants were randomized 1:1:1 to oral rivaroxaban 2.5 mg or 5 mg or 1 mg/kg subcutaneous enoxaparin twice daily in addition to dual antiplatelet therapy (DAPT; aspirin 100 mg and clopidogrel 75 mg once daily) for a mean of 3.7 days. Main Outcomes and Measures The primary safety end point was bleeding events, as defined by the International Society on Thrombosis and Haemostasis, and the primary efficacy end point was major adverse cardiovascular events (MACEs), including cardiac death, myocardial infarction, rerevascularization, or stroke during the 6-month follow-up. Results Of 2055 enrolled patients, 2046 (99.6%) completed the trial (mean [SD] age 65.8 [8.2] years, 1443 [70.5%] male) and were randomized to enoxaparin (680 patients), rivaroxaban 2.5 mg (683 patients), or rivaroxaban 5 mg (683 patients). Bleeding rates were 46 patients (6.8%) in the enoxaparin group, 32 patients (4.7%) in the rivaroxaban 2.5 mg group, and 36 patients (5.3%)in the rivaroxaban 5 mg group (rivaroxaban 2.5 mg vs enoxaparin: noninferiority hazard ratio [HR] , 0.68; 95% CI, 0.43 to 1.07; P  = .005; rivaroxaban 5 mg vs enoxaparin: noninferiority HR, 0.88; 95% CI, 0.70 to 1.09; P  = .001). The incidence of MACEs was similar among groups, and noninferiority was reached in the rivaroxaban 5 mg group (HR, 0.60; 95% CI, 0.31 to 1.16, P  = .02) but not in the rivaroxaban 2.5 mg group (HR, 0.68; 95% CI, 0.36 to 1.30; P  = .05) compared with the enoxaparin group. Conclusions and Relevance In this equivalence and noninferiority trial, oral rivaroxaban 5 mg showed noninferiority to subcutaneous enoxaparin (1 mg/kg) for patients with ACS treated with DAPT during the acute phase. Results of this feasibility study provide useful information for designing future randomized clinical trials with sufficient sample sizes. Trial Registration ClinicalTrials.gov Identifier: NCT03363035
    Type of Medium: Online Resource
    ISSN: 2574-3805
    URL: Article
    DOI: 10.1001/jamanetworkopen.2022.55709
    Language: English
    Publisher: American Medical Association (AMA)
    Publication Date: 2023
    detail.hit.zdb_id: 2931249-8
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  • 2
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    Geographic factors explain soil nitrogen and phosphorus stoichiometry in the Chinese wetlands
    Elsevier BV ; 2023
    In:  CATENA Vol. 231 ( 2023-10), p. 107302-
    Details
    In: CATENA, Elsevier BV, Vol. 231 ( 2023-10), p. 107302-
    Type of Medium: Online Resource
    ISSN: 0341-8162
    URL: Article
    DOI: 10.1016/j.catena.2023.107302
    RVK:
    RA 1595
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2023
    detail.hit.zdb_id: 1492500-X
    detail.hit.zdb_id: 519608-5
    SSG: 13
    SSG: 14
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  • 3
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    Attention‐based sensor fusion for emotion recognition from human motion by combining convolutional neural network and weighted kernel support vector machine and using inertial measurement unit signals
    Institution of Engineering and Technology (IET) ; 2023
    In:  IET Signal Processing Vol. 17, No. 4 ( 2023-04)
    Details
    In: IET Signal Processing, Institution of Engineering and Technology (IET), Vol. 17, No. 4 ( 2023-04)
    Abstract: The remarkable development of human–computer interactions has created an urgent need for machines to be able to recognise human emotions. Human motions play a key role in emphasising and conveying emotions to meet the complexity of daily application scenarios, such as medical rehabilitation and social education. Therefore, this paper aims to explore hidden emotional states from human motions. Accordingly, we proposed a novel approach for emotion recognition using multiple inertial measurement unit (IMU) sensors worn on different body parts. First, the mapping relationship between emotion and human motion was established through fuzzy comprehensive evaluation, and data were collected for six emotional states: sleepy, bored, excited, tense, angry, and distressed. Second, the preprocessed data were used as input in a lightweight convolutional neural network to extract discriminative features. Third, an attention‐based sensor fusion module was developed to obtain the importance scores of each IMU sensor for generating a fused feature representation. In the recognition phase, we constructed a weighted kernel support vector machine (SVM) model with an auxiliary fuzzy function to improve the weight calculation method of kernel functions in a multiple kernel SVM. Finally, the results obtained are compared with those of similar state‐of‐the‐art studies, the proposed method showed a higher accuracy (99.02%) for the six emotional states mentioned above. These findings may promote the development of social robots with non‐verbal emotional communication capabilities.
    Type of Medium: Online Resource
    ISSN: 1751-9675 , 1751-9683
    URL: Issue
    URL: Article
    DOI: 10.1049/sil2.v17.4
    DOI: 10.1049/sil2.12201
    Language: English
    Publisher: Institution of Engineering and Technology (IET)
    Publication Date: 2023
    detail.hit.zdb_id: 2278782-3
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  • 4
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    Reduced myocardial septal function assessed by cardiac magnetic resonance feature tracking in patients with hypertrophic obstructive cardiomyopathy: associated with histological myocardial fibrosis and ventricular arrhythmias
    Oxford University Press (OUP) ; 2022
    In:  European Heart Journal - Cardiovascular Imaging Vol. 23, No. 8 ( 2022-07-21), p. 1006-1015
    Details
    In: European Heart Journal - Cardiovascular Imaging, Oxford University Press (OUP), Vol. 23, No. 8 ( 2022-07-21), p. 1006-1015
    Abstract: Echocardiographic studies suggest that strain is related to myocardial fibrosis (MF) and ventricular arrhythmias (VA) in hypertrophic cardiomyopathy (HCM) patients. Cardiac magnetic resonance feature tracking (CMR-FT) also allows strain analysis, but little is known whether it provides incremental value to late gadolinium enhancement imaging (LGE). This study aimed to explore the relationship between CMR-FT-derived strain parameters and histopathology MF and VA and its incremental value to LGE in obstructive HCM (HOCM) patients undergoing septal myectomy. Methods and results One hundred and twenty-three symptomatic HOCM patients underwent CMR examination, followed by septal myectomy. The abnormally increased histological MF was defined as higher than the mean + 2 standard deviation (SD) of nine control autopsy subjects who had no history of cardiovascular disease. Septal strain parameters and septal LGE were evaluated at the site of surgical myectomy. Among HOCM patients without LGE, septal circumferential (P = 0.003), longitudinal (P = 0.001), and radial (P = 0.02) strains were significantly impaired in patients with increased histological MF than those without. Histological MF was significantly associated with septal circumferential strain (r = 0.32, P & lt; 0.001), septal longitudinal strain (r = 0.42, P & lt; 0.001), and septal radial strain (r = −0.27, P = 0.003). On multivariate analysis, septal longitudinal strain was independently associated with histological MF [β, 0.19 (0.05–0.34); P = 0.01], and VA [odds ratio, 1.10 (1.01–1.19); P = 0.02] . Moreover, septal longitudinal strain was incremental to septal %LGE in detecting increased MF (P = 0.001) and VA (P = 0.048). Conclusions Septal longitudinal strain at CMR is independently related to histological MF and occurrence of VA in HOCM patients. Moreover, it provides incremental value over LGE in detecting increased MF and VA.
    Type of Medium: Online Resource
    ISSN: 2047-2404 , 2047-2412
    URL: Article
    DOI: 10.1093/ehjci/jeac032
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2022
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    detail.hit.zdb_id: 2647943-6
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  • 5
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    The effect of underwater supplemental light on the growth of V.spinulosa Yan and the restoration process of water
    Elsevier BV ; 2023
    In:  Process Safety and Environmental Protection Vol. 169 ( 2023-01), p. 328-336
    Details
    In: Process Safety and Environmental Protection, Elsevier BV, Vol. 169 ( 2023-01), p. 328-336
    Type of Medium: Online Resource
    ISSN: 0957-5820
    URL: Article
    DOI: 10.1016/j.psep.2022.11.043
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2023
    detail.hit.zdb_id: 2008004-9
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  • 6
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    Abstract 5463: BPI-442096: A potent and selective inhibitor of SHP2 for the treatment of multiple cancers
    American Association for Cancer Research (AACR) ; 2022
    In:  Cancer Research Vol. 82, No. 12_Supplement ( 2022-06-15), p. 5463-5463
    Details
    In: Cancer Research, American Association for Cancer Research (AACR), Vol. 82, No. 12_Supplement ( 2022-06-15), p. 5463-5463
    Abstract: Src homology region 2 domain-containing phosphatase-2 (SHP-2) is a key node in the RAS signaling pathway. Allosteric inhibition of SHP2 phosphatase is a potential therapeutic strategy for cancers harboring oncogenic mutations in the KRAS pathway. SHP2 also participates in the signal transduction downstream of regulatory immunoreceptors, and it has been shown in preclinical models that SHP2 inhibition drives anti-tumor immunity through modulation of both innate and adaptive mechanism. BPI-442096 is a potent, selective, and orally bioavailable small molecule SHP2 inhibitor. It exhibited significant anti-proliferation activities against multiple KRAS mutant cancer cell lines, including those from NSCLC, PDAC, CRPC, etc. BPI-442096 dose-dependently inhibited SHP2 phosphatase and downstream ERK phosphorylation in cancer cells, as well as NFAT reporter gene expression downstream of PD-1/PD-L1 signaling in immune cells. In vivo, BPI-442096 demonstrated strong tumor growth inhibition in KRASG12C, KRASG12D, and KRASG12V mutant xenograft mouse models. BPI-442096 also exhibited anti-tumor immunity in the MC38 syngeneic model, as a single agent or in combination with anti-PD1/PD-L1 drugs. Moreover, BPI-442096 combining with KRASG12C inhibitor may reverse intrinsic and acquired resistance to KRASG12C inhibition. Adequate oral exposure across multiple pre-clinical species and good ADME properties ensured the druggability of BPI-442096. In conclusion, BPI-442096 exhibits a robust anti-tumor effect in multiple KRAS mutant models and enhanced anti-cancer immunity in syngeneic mouse models, and it shows multiple combination potentials to overcome drug resistance. Phase 1 clinical trial is planned in early 2022. Citation Format: Ling Li, Bang Fu, Han Han, Zhongxin Sun, Xiangdong Zhao, Xuepeng Jv, Jun Tong, Jiayu Zhao, Zhengyao Zou, Haibo Chen, Xiaoyun Liu, Wei Ren, Yinlong Li, Wenmao Wu, Jing Guo, Dan Yan, Xiangyong Liu, Hong Lan, Hao Wu, Lieming Ding, Jiabing Wang. BPI-442096: A potent and selective inhibitor of SHP2 for the treatment of multiple cancers [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr 5463.
    Type of Medium: Online Resource
    ISSN: 1538-7445
    URL: Article
    DOI: 10.1158/1538-7445.AM2022-5463
    Language: English
    Publisher: American Association for Cancer Research (AACR)
    Publication Date: 2022
    detail.hit.zdb_id: 2036785-5
    detail.hit.zdb_id: 1432-1
    detail.hit.zdb_id: 410466-3
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  • 7
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    Abstract 501: Discovery of BPI-460372, a potent and selective inhibitor of TEAD for the treatment of solid tumors harboring Hippo pathway aberrations
    American Association for Cancer Research (AACR) ; 2023
    In:  Cancer Research Vol. 83, No. 7_Supplement ( 2023-04-04), p. 501-501
    Details
    In: Cancer Research, American Association for Cancer Research (AACR), Vol. 83, No. 7_Supplement ( 2023-04-04), p. 501-501
    Abstract: The Hippo signaling pathway is critical for the regulation of organ development, tissue homeostasis, and tumorigenesis by controlling the activation status of yes-associated protein (YAP) or its homolog PDZ-binding motif (TAZ). As a major downstream effector, the transcription factor TEAD is activated by forming a complex with YAP/TAZ. Hippo pathway aberrations, such as NF2-deficiency or LATS1/2 mutations leading to hyperactivation of YAP/TAZ and subsequent activation of TEAD, have been reported in many cancers, including mesothelioma, meningioma, soft tissue sarcoma and non-small cell lung cancer. Inhibiting TEAD auto-palmitoylation by directly blocking the palmitoylation pocket of TEAD is a potential therapeutic approach for cancer treatment. Here we present BPI-460372, a novel small molecule that directly blocks the TEAD auto-palmitoylation. BPI-460372 covalently and irreversibly binds to the cysteine residue in the TEAD palmitoylation pocket, preventing TEAD palmitoylation and inhibiting its biological function. BPI-460372 significantly inhibits the expression of a TEAD-responsive element reporter, as well as the mRNA of downstream target genes such as CTGF and CYR61 in NF2-deficient cells. At the cellular level, BPI-460372 strongly inhibited the proliferation of tumor cells harboring Hippo pathway aberrations. BPI-460372 also significantly suppressed tumor growth in NF2-deficient or LATS1/2 mutation xenograft models. In addition, BPI-460372 exhibited excellent oral bioavailability, high exposure across multiple species, and adequate ADME properties. In conclusion, BPI-460372 is a potent and selective TEAD palmitoylation inhibitor for the treatment of solid tumors harboring Hippo pathway aberrations. It is planned to enter Phase I clinical trial in China in early 2023. Citation Format: Hongling Shen, Xiaofeng Xu, Hongfei Rong, Xizhen Song, Jinheng Gao, Jie Chen, Di Zhu, Xiangdong Zhao, Jun Tong, Zhengyao Zou, Xiaoyun Liu, Jin Guo, Yan Xu, Yabin Li, Xiangyong Liu, Hong Chen, Jiayu Zhao, Yanju Liu, Xuepeng Ju, Haibo Chen, Hong Lan, Lieming Ding, Jiabing Wang. Discovery of BPI-460372, a potent and selective inhibitor of TEAD for the treatment of solid tumors harboring Hippo pathway aberrations [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 1 (Regular and Invited Abstracts); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(7_Suppl):Abstract nr 501.
    Type of Medium: Online Resource
    ISSN: 1538-7445
    URL: Article
    DOI: 10.1158/1538-7445.AM2023-501
    Language: English
    Publisher: American Association for Cancer Research (AACR)
    Publication Date: 2023
    detail.hit.zdb_id: 2036785-5
    detail.hit.zdb_id: 1432-1
    detail.hit.zdb_id: 410466-3
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  • 8
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    Observer-Based Robust Tracking Control for a Class of Switched Nonlinear Cascade Systems
    Hindawi Limited ; 2013
    In:  Mathematical Problems in Engineering Vol. 2013 ( 2013), p. 1-9
    Details
    In: Mathematical Problems in Engineering, Hindawi Limited, Vol. 2013 ( 2013), p. 1-9
    Abstract: This paper is devoted to robust output feedback tracking control design for a class of switched nonlinear cascade systems. The main goal is to ensure the global input-to-state stable (ISS) property of the tracking error nonlinear dynamics with respect to the unknown structural system uncertainties and external disturbances. First, a nonlinear observer is constructed through state transformation to reconstruct the unavailable states, where only one parameter should be determined. Then, by virtue of the nonlinear sliding mode control (SMC), a discontinuous nonlinear output feedback controller is designed using a backstepping like design procedure to ensure the ISS property. Finally, an example is provided to show the effectiveness of the proposed approach.
    Type of Medium: Online Resource
    ISSN: 1024-123X , 1563-5147
    URL: Article
    DOI: 10.1155/2013/136863
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2013
    detail.hit.zdb_id: 2014442-8
    SSG: 11
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  • 9
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    Structures and pyroelectric properties for [111]‐oriented Mn‐doped rhombohedral 0.36PIN‐0.36PMN‐0.28PT crystal
    Wiley ; 2019
    In:  Journal of the American Ceramic Society Vol. 102, No. 12 ( 2019-12), p. 7329-7335
    Details
    In: Journal of the American Ceramic Society, Wiley, Vol. 102, No. 12 ( 2019-12), p. 7329-7335
    Abstract: The crystal structures, pyroelectric properties, and thermal stability of [111]‐oriented 0.5 mol% Mn‐doped 0.36Pb(In 1/2 Nb 1/2 )O 3 ‐0.36Pb(Mg 1/3 Nb 2/3 )O 3 ‐0.28PbTiO 3 (Mn‐0.36PIN‐0.36PMN‐0.28PT) ternary single crystal were investigated. The temperature dependence of the Raman spectra and dielectric properties revealed that the crystal exhibited a rhombohedral ( R ) structure at room temperature, and ferroelectric R   →  tetragonal ( T ) and ferroelectric T to paraelectric cubic ( C ) phase transitions at 130 and 175°C respectively. The single crystal had a high remnant polarization of P r  = 38 μC cm –2 and coercive field of E C  = 12 kV cm –1 at room temperature and a frequency of f  = 100 Hz. The values of P r and E C decreased with increasing temperature, exhibiting anomalies near their phase‐transition temperatures, which coincided with changes in the Raman spectra and dielectric properties. Furthermore, at 25°C and f  = 100 Hz, the single crystal had high pyroelectric coefficients of p  = 8.7 × 10 −4  C m −2  K −1 , figures of merit for the current responsivity of F i  = 3.5 × 10 −10  m V −1 , the voltage responsivity of F v  = 0.08 m 2  C −1 , and the detectivity of F d  = 30.1 × 10 −5  Pa −1/2 . These values were weakly dependent on temperature below 120°C. In addition, the room‐temperature pyroelectric coefficients of the ternary single crystal maintain over 83% of the original value at thermal annealing temperatures below 120°C. These outstanding pyroelectric properties, together with high thermal stability, indicate that [111]‐oriented rhombohedral Mn‐0.36PIN‐0.36PMN‐0.28PT ternary single crystal is a new potential candidate for infrared detection applications.
    Type of Medium: Online Resource
    ISSN: 0002-7820 , 1551-2916
    URL: Issue
    URL: Article
    DOI: 10.1111/jace.v102.12
    DOI: 10.1111/jace.16600
    RVK:
    VA 1120
    Language: English
    Publisher: Wiley
    Publication Date: 2019
    detail.hit.zdb_id: 2008170-4
    detail.hit.zdb_id: 219232-9
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  • 10
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    Influence of regular addition of ore on treatment efficiency and aquatic organisms in living machine system for black water treatment
    Elsevier BV ; 2022
    In:  Journal of Cleaner Production Vol. 341 ( 2022-03), p. 130928-
    Details
    In: Journal of Cleaner Production, Elsevier BV, Vol. 341 ( 2022-03), p. 130928-
    Type of Medium: Online Resource
    ISSN: 0959-6526
    URL: Article
    DOI: 10.1016/j.jclepro.2022.130928
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2022
    detail.hit.zdb_id: 1179393-4
    detail.hit.zdb_id: 2029338-0
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