In:
International Journal of Genomics, Hindawi Limited, Vol. 2019 ( 2019-09-03), p. 1-12
Abstract:
This study was designed to explore the association between Graves disease (GD) and thyroid-stimulating hormone receptor (TSHR) and cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) single nucleotide polymorphisms (SNPs). We studied a total of 1217 subjects from a Han population in northern Anhui province in China. Six SNPs within TSHR (rs179247, rs12101261, rs2284722, rs4903964, rs2300525, and rs17111394) and four SNPs within CTLA-4 (rs10197319, rs231726, rs231804, and rs1024161) were genotyped via a Taqman probe technique using a Fluidigm EP1 platform. The TSHR alleles rs179247-G, rs12101261-C, and rs4903964-G were negatively correlated with GD, whereas the rs2284722-A and rs17111394-C alleles were positively correlated with GD. Analyzing TSHR SNPs at rs179247, rs2284722, rs12101261, and rs4903964 yielded 8 different haplotypes. There were positive correlations between GD risk and the haplotypes AGTA and AATA ( OR = 1.27 , 95 % CI = 1.07 ‐ 1.50 , P = 0.005 ; OR = 1.45 , 95 % CI = 1.21 ‐ 1.75 , P 〈 0.001 , respectively). There were negative correlations between GD risk and the haplotype GGCG ( OR = 0.56 , 95 % CI = 0.46 ‐ 0.67 , P 〈 0.001 ). With respect to haplotypes based on SNPs at the TSHR rs2300525 and rs17111394 loci, the CC haplotype was positively correlated with GD risk ( OR = 1.32 , 95 % CI = 1.08 ‐ 1.60 , P = 0.006 ). Analyzing CTLA-4 SNPs at rs231804, rs1024161, and rs231726 yielded four haplotypes, of which AAA was positively correlated with GD risk ( OR = 1.21 , 95 % CI = 1.02 ‐ 1.43 , P = 0.029 ). Polymorphisms at rs179247, rs12101261, rs2284722, rs4903964, and rs17111394 were associated with GD susceptibility. Haplotypes of both TSHR and CTLA-4 were additionally related to GD risk.
Type of Medium:
Online Resource
ISSN:
2314-436X
,
2314-4378
DOI:
10.1155/2019/6982623
Language:
English
Publisher:
Hindawi Limited
Publication Date:
2019
detail.hit.zdb_id:
2711883-6
SSG:
12
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