In:
BMJ Open, BMJ, Vol. 8, No. 8 ( 2018-08), p. e020545-
Abstract:
The level of vitamin D is considered to be associated with the development and progression of heart failure (HF). However, it is still unclear whether supplementation of vitamin D could improve ventricular remodelling in patients with HF. This study aimed to systematically evaluate the influence and safety of additional vitamin D supplementation on ventricular remodelling in patients with HF. Design This study is a meta-analysis of randomised controlled trials (RCTs). Setting The PubMed, EMBASE, CNKI, Cochrane library, Web of Science databases and grey literature were searched for RCTs regarding the effect of vitamin D on ventricular remodelling in patients with HF (from database creation to October 2017). RevMan V.5.3 software was employed for data analysis. Participants Seven RCTs with a total of 465 patients, including 235 cases in the vitamin D group and 230 cases in the control group, were included. Primary and secondary outcome measures Left ventricular end-diastolic dimension (LVEDD), left ventricular ejection fraction (LVEF) and the incidence of adverse reactions. Results Compared with the control group, a decrease in the LVEDD (mean difference (MD)=−2.31 mm, 95% CI −4.15 to −0.47, p=0.01) and an increase in the LVEF (MD=4.18%, 95% CI 0.36 to 7.99, p=0.03) were observed in the vitamin D group. Subgroup analysis also revealed a reduced LVEDD in adults ( 〉 18 years) and adolescents ( 〈 18 years) of the vitamin D group relative to that in those of the control group. High-dose vitamin D ( 〉 4000 IU/day) was more effective at reducing the LVEDD than low-dose vitamin D ( 〈 4000 IU/day). Moreover, vitamin D supplementation was more effective at reducing the LVEDD and increasing the LVEF in patients with reduced ejection fraction than in patients without reduced ejection fraction. Conclusion Vitamin D supplementation inhibits ventricular remodelling and improves cardiac function in patients with HF. Trial registration number CRD42017073893.
Type of Medium:
Online Resource
ISSN:
2044-6055
,
2044-6055
DOI:
10.1136/bmjopen-2017-020545
Language:
English
Publisher:
BMJ
Publication Date:
2018
detail.hit.zdb_id:
2599832-8
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