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  • 1
    Online Resource
    Online Resource
    Joint concanavalin A-aptamer enabled dual recognition for anti-interference visual detection of Salmonella typhimurium in complex food matrices
    Elsevier BV ; 2023
    In:  Food Chemistry Vol. 426 ( 2023-11), p. 136581-
    Details
    In: Food Chemistry, Elsevier BV, Vol. 426 ( 2023-11), p. 136581-
    Type of Medium: Online Resource
    ISSN: 0308-8146
    URL: Article
    DOI: 10.1016/j.foodchem.2023.136581
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2023
    detail.hit.zdb_id: 1483647-6
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  • 2
    Online Resource
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    Status of diagnosis and preventative treatment for primary headache disorders: real-world data of unmet needs in China
    Springer Science and Business Media LLC ; 2023
    In:  The Journal of Headache and Pain Vol. 24, No. 1 ( 2023-09-01)
    Details
    In: The Journal of Headache and Pain, Springer Science and Business Media LLC, Vol. 24, No. 1 ( 2023-09-01)
    Abstract: Headache disorders are widely prevalent and pose a considerable economic burden on individuals and society. Globally, misdiagnosis and inadequate treatment of primary headache disorders remain significant challenges, impeding the effective management of such conditions. Despite advancements in headache management over the last decade, a need for comprehensive evaluations of the status of primary headache disorders in China regarding diagnosis and preventative treatments persists. Methods In the present study, we analyzed the established queries in the Survey of Fibromyalgia Comorbidity with Headache (SEARCH), focusing on previous diagnoses and preventative treatment regimens for primary headache disorders. This cross-sectional study encompassed adults diagnosed with primary headache disorders who sought treatment at 23 hospitals across China between September 2020 to May 2021. Results The study comprised 2,868 participants who were systematically examined. Migraine and tension-type headaches (TTH) constituted a majority of the primary headache disorders, accounting for 74.1% (2,124/2,868) and 23.3% (668/2,868) of the participants, respectively. Medication overuse headache (MOH) affected 8.1% (231/2,868) of individuals with primary headache disorders. Over half of the individuals with primary headache disorders (56.6%, 1,624/2,868) remained undiagnosed. The previously correct diagnosis rates for migraine, TTH, TACs, and MOH were 27.3% (580/2,124), 8.1% (54/668), 23.2% (13/56), and 3.5% (8/231), respectively. The misdiagnosis of “Nervous headache” was found to be the most prevalent among individuals with migraine (9.9%, 211/2,124), TTH (10.0%, 67/668), trigeminal autonomic cephalalgias (TACs) (17.9%, 10/56), and other primary headache disorders (10.0%, 2/20) respectively. Only a minor proportion of individuals with migraine (16.5%, 77/468) and TTH (4.7%, 2/43) had received preventive medication before participating in the study. Conclusions While there has been progress made in the rate of correct diagnosis of primary headache disorders in China compared to a decade ago, the prevalence of misdiagnosis and inadequate treatment of primary headaches remains a veritable issue. As such, focused efforts are essential to augment the diagnosis and preventive treatment measures related to primary headache disorders in the future.
    Type of Medium: Online Resource
    ISSN: 1129-2377
    URL: Article
    DOI: 10.1186/s10194-023-01654-6
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2023
    detail.hit.zdb_id: 2020168-0
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  • 3
    Online Resource
    Online Resource
    The prevalence and clinical features of fibromyalgia in Chinese hospital patients with primary headache: The survey of fibromyalgia comorbid with headache
    Wiley ; 2023
    In:  Headache: The Journal of Head and Face Pain Vol. 63, No. 1 ( 2023-01), p. 62-70
    Details
    In: Headache: The Journal of Head and Face Pain, Wiley, Vol. 63, No. 1 ( 2023-01), p. 62-70
    Abstract: The aims were to explore the prevalence and clinical features of fibromyalgia in Chinese hospital patients with primary headache. Background Studies done in non‐Chinese populations suggest that around one‐third of patients with primary headache have fibromyalgia, but data from mainland China are limited. Investigations into the prevalence and clinical features of fibromyalgia in Chinese patients with primary headache would improve our understanding of these two complex disease areas and help guide future clinical practice. Methods This cross‐sectional study included adults with primary headache treated at 23 Chinese hospitals from September 2020 to May 2021. Fibromyalgia was diagnosed using the modified 2010 American College of Rheumatology criteria. Mood and insomnia were evaluated employing the Hospital Anxiety and Depression Scale and the Insomnia Severity Index. Results A total of 2782 participants were analyzed. The fibromyalgia prevalence was 6.0% (166/2782; 95% confidence interval: 5.1%, 6.8%). Compared to primary headache patients without combined fibromyalgia, patients with primary headache combined with fibromyalgia were more likely to be older (47.8 vs. 41.7 years), women (83.7% [139/166] vs. 72.8% [1904/2616] ), less educated (65.1% [108/166] vs. 45.2% [1183/2616] ), and with longer‐duration headache (10.0 vs. 8.0 years). Such patients were more likely to exhibit comorbid depression (34.3% [57/166] vs. 9.9% [260/2616] ), anxiety (16.3% [27/166] vs. 2.7% [70/2612] ), and insomnia (58.4% [97/166] vs. 17.1% [447/2616] ). Fibromyalgia was more prevalent in those with chronic (rather than episodic) migraine (11.1% [46/414] vs. 4.4% [72/1653] , p   〈  0.001) and chronic (rather than episodic) tension‐type headache (11.5% [27/235] vs. 4.6% [19/409] , p  = 0.001). Most fibromyalgia pain was in the shoulders, neck, and upper back. Conclusions The prevalence of fibromyalgia in mainland Chinese patients with primary headache was 6.0%. Fibromyalgia was more common in those with chronic rather than episodic headache. The most common sites of fibromyalgia pain were the neck, shoulders, and back.
    Type of Medium: Online Resource
    ISSN: 0017-8748 , 1526-4610
    URL: Issue
    URL: Article
    DOI: 10.1111/head.v63.1
    DOI: 10.1111/head.14443
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2020316-0
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  • 4
    Online Resource
    Online Resource
    Damage Classification for Masonry Historic Structures Using Convolutional Neural Networks Based on Still Images
    Wiley ; 2018
    In:  Computer-Aided Civil and Infrastructure Engineering Vol. 33, No. 12 ( 2018-12), p. 1073-1089
    Details
    In: Computer-Aided Civil and Infrastructure Engineering, Wiley, Vol. 33, No. 12 ( 2018-12), p. 1073-1089
    Abstract: Manual inspection (i.e., visual inspection and/or with professional equipment) is the most predominant approach for identifying and assessing superficial damage of masonry historic structures at present. However, this method is costly and at times difficult to apply to remote structures or components. Existing convolutional neural network (CNN)‐based damage detection methods have not been specifically designed for the multiple damage identification of masonry historic structures. To overcome these limits, a deep architecture of CNN damage classification techniques for masonry historic structures is proposed in this article using a sliding window‐based CNN method to identify and locate four categories of damage (intact, crack, efflorescence, and spall) with an accuracy of 94.3%. This is the first attempt to identify the multidamage of historic masonry structures based on CNN techniques and achieve excellent classification results. The data are only trained and tested from images of the Forbidden City Wall in China, and the pixel resolutions of stretcher brick images and header brick images are 480 × 105 and 210 × 105, respectively. Two CNNs (AlexNet and GoogLeNet) are both trained on a small dataset (2,000 images for training, 400 images for validation and testing) and a large dataset (20,000 images for training, 4,000 images for validation and testing). The performance of the trained model (94.3% accuracy) is examined on five new images with 1,860 × 1,260 pixel resolutions.
    Type of Medium: Online Resource
    ISSN: 1093-9687 , 1467-8667
    URL: Issue
    URL: Article
    DOI: 10.1111/mice.2018.33.issue-12
    DOI: 10.1111/mice.12411
    Language: English
    Publisher: Wiley
    Publication Date: 2018
    detail.hit.zdb_id: 2016953-X
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  • 5
    Online Resource
    Online Resource
    Comprehensive parametric analysis, design and performance assessment of a solar dish/Stirling system
    Elsevier BV ; 2021
    In:  Process Safety and Environmental Protection Vol. 146 ( 2021-02), p. 276-291
    Details
    In: Process Safety and Environmental Protection, Elsevier BV, Vol. 146 ( 2021-02), p. 276-291
    Type of Medium: Online Resource
    ISSN: 0957-5820
    URL: Article
    DOI: 10.1016/j.psep.2020.09.007
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2021
    detail.hit.zdb_id: 2008004-9
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  • 6
    Online Resource
    Online Resource
    Combinatorial Approaches to Enhance DNA Damage following Enzyme-Mediated Depletion of L-Cys for Treatment of Pancreatic Cancer
    Elsevier BV ; 2021
    In:  Molecular Therapy Vol. 29, No. 2 ( 2021-02), p. 775-787
    Details
    In: Molecular Therapy, Elsevier BV, Vol. 29, No. 2 ( 2021-02), p. 775-787
    Type of Medium: Online Resource
    ISSN: 1525-0016
    URL: Article
    DOI: 10.1016/j.ymthe.2020.10.016
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2021
    detail.hit.zdb_id: 2001818-6
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  • 7
    Online Resource
    Online Resource
    Pre-attack and pre-episode symptoms in cluster headache: a multicenter cross-sectional study of 327 Chinese patients
    Springer Science and Business Media LLC ; 2022
    In:  The Journal of Headache and Pain Vol. 23, No. 1 ( 2022-12)
    Details
    In: The Journal of Headache and Pain, Springer Science and Business Media LLC, Vol. 23, No. 1 ( 2022-12)
    Abstract: There have been a few studies regarding the pre-attack symptoms (PAS) and pre-episode symptoms (PES) of cluster headache (CH), but none have been conducted in the Chinese population. The purpose of this study was to identify the prevalence and features of PAS and PES in Chinese patients, as well as to investigate their relationships with pertinent factors. Methods The study included patients who visited a tertiary headache center and nine other headache clinics between January 2019 and September 2021. A questionnaire was used to collect general data and information about PAS and PES. Results Among the 327 patients who met the CH criteria (International Classification of Headache Disorders, 3rd edition), 269 (82.3%) patients experienced at least one PAS. The most common PAS were head and facial discomfort (74.4%). Multivariable logistic regression analysis depicted that the number of triggers (OR = 1.798, p  = 0.001), and smoking history (OR = 2.067, p  = 0.026) were correlated with increased odds of PAS. In total, 68 (20.8%) patients had PES. The most common symptoms were head and facial discomfort (23, 33.8%). Multivariable logistic regression analysis showed that the number of triggers were associated with increased odds of PES (OR = 1.372, p  = 0.005). Conclusions PAS are quite common in CH patients, demonstrating that CH attacks are not comprised of a pain phase alone; investigations of PAS and PES could help researchers better understand the pathophysiology of CH.
    Type of Medium: Online Resource
    ISSN: 1129-2369 , 1129-2377
    URL: Article
    DOI: 10.1186/s10194-022-01459-z
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2022
    detail.hit.zdb_id: 2020168-0
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  • 8
    Online Resource
    Online Resource
    Should migraine without aura be further divided? A study of 1444 female patients with migraine without aura
    Springer Science and Business Media LLC ; 2023
    In:  The Journal of Headache and Pain Vol. 24, No. 1 ( 2023-03-01)
    Details
    In: The Journal of Headache and Pain, Springer Science and Business Media LLC, Vol. 24, No. 1 ( 2023-03-01)
    Abstract: To explore the possibility of further dividing migraine without aura (MWA), 1444 female patients fulfilled the criterion were recruited, and grouped basing on the association of MWA onset with menarche and childbirth (group J1, onset before menarche; group J2, onset between menarche and childbirth; group J3, onset after childbirth). By comparing migraine (side, location, aggravated by routine physical activity, NRS score, frequency, accompanying symptoms, with premonitory symptom (PS) and trigger, sum of PS and trigger) and migraine-related factors [chronic daily headache, medicine overused headache, body mass index (BMI), education level, exercise status, sleep status, consumption of tea/coffee/alcohol, patient health questionnaire-9 (PHQ-9) score and generalized anxiety disorder-7, (GAD-7) score)] among groups, it was found that the J1 group and the J2 group presented more typical migraine features than the J3 group; 2) the J3 group was more prone to emotion and sleep disorders, weight management issues, frequent migraine attacks and medication overuse. This study provided a basis for further dividing MWA. Genetic research should be conducted and treatment should be prescribed accordingly because the underlying pathogenesis may be different.
    Type of Medium: Online Resource
    ISSN: 1129-2377
    URL: Article
    DOI: 10.1186/s10194-023-01540-1
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2023
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  • 9
    Online Resource
    Online Resource
    Response inhibition alterations in migraine: evidence from event-related potentials and evoked oscillations
    Springer Science and Business Media LLC ; 2020
    In:  The Journal of Headache and Pain Vol. 21, No. 1 ( 2020-12)
    Details
    In: The Journal of Headache and Pain, Springer Science and Business Media LLC, Vol. 21, No. 1 ( 2020-12)
    Abstract: Migraine is characterized by a hypersensitivity to environmental stimulation which climaxes during headache attacks but persists during attack-free period. Despite ongoing debates about the nature of the mechanisms giving rise to this abnormality, the presence of deficient inhibitory cortical processes has been proposed to be one possible mechanism underlying its pathogenesis. Empirical evidence supporting this claim is mainly based on previous accounts showing functional cortical disexcitability in the sensory domain. Considering that a general inhibitory control process can play an important role across early to later stage of information processing, this may indicate the important role other dimensions of inhibitory control can play in migraine disability. The present study examined the pathophysiological features of inhibitory control that takes place during suppression of prepotent responses in migraineurs. Methods Twenty-two patients with migraine without aura (mean age = 30.86 ± 5.69 years; 19 females) during the interictal period and 25 healthy controls (mean age = 30.24 ± 3.52 years; 18 females) were recruited. We used a stop signal task in combination with event-related potentials (ERPs) to examine participants’ neural activity supporting response inhibition. Results Behaviorally, migraineurs exhibited prolonged stop signal reaction times relative to healthy controls. At the neural level, the amplitude of the stop-N2 over fronto-central, central and centro-parietal scalp regions, a component of the ERPs related to conflict monitoring during early, non-motoric stages of inhibition, was significantly increased in migraineurs. Meanwhile, the amplitude of the stop-P3 over central and centro-parietal scalp regions, a component of the ERPs reflecting late-stage inhibition of the motor system and cognitive evaluation of motor inhibition, was also significantly increased in migraineurs. Ultimately, our time-frequency analysis further revealed increased delta activity in migraineurs. Conclusions Consistent with the theory that alterations in cognitive cortical processes are a key signature of migraine, our findings revealed an abnormal state of suppressing prepotent responses in migraineurs, which can be attributed to cortical disexcitability of the pre-frontal executive network and centro-parietal sensorimotor network. These novel findings extend to show the existence of dysfunctional inhibition control that occurs during suppression of prepotent responses in migraneurs.
    Type of Medium: Online Resource
    ISSN: 1129-2369 , 1129-2377
    URL: Article
    DOI: 10.1186/s10194-020-01187-2
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2020
    detail.hit.zdb_id: 2020168-0
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  • 10
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    Online Resource
    Functional correlation of ATP1A2 mutations with phenotypic spectrum: from pure hemiplegic migraine to its variant forms
    Springer Science and Business Media LLC ; 2021
    In:  The Journal of Headache and Pain Vol. 22, No. 1 ( 2021-12)
    Details
    In: The Journal of Headache and Pain, Springer Science and Business Media LLC, Vol. 22, No. 1 ( 2021-12)
    Abstract: Mutations in ATP1A2 , the gene encoding the α2 subunit of Na + /K + -ATPase, are the main cause of familial hemiplegic migraine type 2 (FHM2). The clinical presentation of FHM2 with mutations in the same gene varies from pure FHM to severe forms with epilepsy and intellectual disability, but the correlation of these symptoms with different ATP1A2 mutations is still unclear. Methods Ten ATP1A2 missense mutations were selected according to different phenotypes of FHM patients. They caused pure FHM (FHM: R65W, R202Q, R593W, G762S), FHM with epilepsy (FHME: R548C, E825K, R938P), or FHM with epilepsy and intellectual disability (FHMEI: T378N, G615R, D718N). After ouabain resistance and fluorescence modification, plasmids carrying those mutations were transiently transfected into HEK293T and HeLa cells. The biochemical functions were studied including cell survival assays, membrane protein extraction, western blotting, and Na + /K + -ATPase activity tests. The electrophysiological functions of G762S, R938P, and G615R mutations were investigated in HEK293T cells using whole-cell patch-clamp. Homology modeling was performed to determine the locational distribution of ATP1A2 mutations. Results Compared with wild-type pumps, all mutations showed a similar level of protein expression and decreased cell viability in the presence of 1 µM ouabain, and there was no significant difference among the mutant groups. The changes in Na + /K + -ATPase activity were correlated with the severity of FHM phenotypes. In the presence of 100 µM ouabain, the Na + /K + -ATPase activity was FHM  〉  FHME  〉  FHMEI. The ouabain-sensitive Na + /K + -ATPase activity of each mutant was significantly lower than that of the wild-type protein, and there was no significant difference among all mutant groups. Whole-cell voltage-clamp recordings in HEK293T cells showed that the ouabain-sensitive pump currents of G615R were significantly reduced, while those of G762S and R938P were comparable to those of the wild-type strain. Conclusions ATP1A2 mutations cause phenotypes ranging from pure FHM to FHM with epilepsy and intellectual disability due to varying degrees of deficits in biochemical and electrophysiological properties of Na + /K + -ATPase. Mutations associated with intellectual disability presented with severe impairment of Na + /K + -ATPase. Whether epilepsy is accompanied, or the type of epilepsy did not seem to affect the degree of impairment of pump function.
    Type of Medium: Online Resource
    ISSN: 1129-2369 , 1129-2377
    URL: Article
    DOI: 10.1186/s10194-021-01309-4
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2021
    detail.hit.zdb_id: 2020168-0
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