In:
Chemistry & Biodiversity, Wiley, Vol. 19, No. 7 ( 2022-07)
Abstract:
Five new fawcettimine‐type Lycopodium alkaloids, hupertimines A–E ( 1 – 5 ), were discovered from the whole plant of Huperzia serrata , along with two known alkaloids, 8 α ‐hydroxyphlegmariurine B ( 6 ) and 8 β ‐hydroxyphlegmariurine B ( 7 ). The structures of 1 – 7 were identified through HR‐MS, IR, 1 H, 13 C, and 2D NMR, and single‐crystal X‐ray diffraction analysis. Structurally, compound 1 was the fourth example of Lycopodium alkaloid with an ether linkage between C‐5 and C‐13 and 2 was the third example of Lycopodium alkaloid with a 5/5/5/5/6 pentacyclic ring system and featuring a 1‐aza‐7‐oxabicyclo[2.2.1]heptane unit. Compounds 1 – 7 were tested for their BACE1 inhibitory activity. In addition, the correct 1 H‐ and 13 C‐NMR data for 7 were reported in current study.
Type of Medium:
Online Resource
ISSN:
1612-1872
,
1612-1880
DOI:
10.1002/cbdv.202200454
Language:
English
Publisher:
Wiley
Publication Date:
2022
detail.hit.zdb_id:
2139001-0
SSG:
12
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