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  • 1
    Online Resource
    Online Resource
    Tumor microenvironment and cellular senescence: Understanding therapeutic resistance and harnessing strategies
    Elsevier BV ; 2022
    In:  Seminars in Cancer Biology Vol. 86 ( 2022-11), p. 769-781
    Details
    In: Seminars in Cancer Biology, Elsevier BV, Vol. 86 ( 2022-11), p. 769-781
    Type of Medium: Online Resource
    ISSN: 1044-579X
    URL: Article
    DOI: 10.1016/j.semcancer.2021.11.004
    RVK:
    XA 10000
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2022
    detail.hit.zdb_id: 1471735-9
    SSG: 12
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  • 2
    Online Resource
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    Topology of Spade Drills for Wood Drilling Operations, Part 1: Spade Drill Point Geometry Definition
    ASME International ; 2005
    In:  Journal of Manufacturing Science and Engineering Vol. 127, No. 2 ( 2005-05-01), p. 298-309
    Details
    In: Journal of Manufacturing Science and Engineering, ASME International, Vol. 127, No. 2 ( 2005-05-01), p. 298-309
    Abstract: Spade bits, widely and routinely used in the construction industry, have not received any attention in the technical literature, yet there is a pressing need to improve the performance of these bits whose basic design has not changed for decades. To facilitate such improvements, a thorough understanding of the geometric, manufacturing, and cutting mechanics aspects of these tools is necessary. In this two-part paper, the point geometry and manufacturing issues will be discussed. To fundamentally understand the spade drill bit’s behavior, a complete mathematical model of its principal topological elements will be established. In conjunction with this model, the corresponding analytical formulations of the geometry and kinematics of the appropriate manufacturing procedures will also be formulated. In unison, these models will lay the foundation for a methodology and a software package for a detailed geometric analysis of all relevant cutting angle distributions and edge profiles of the spade bit. This will facilitate, at a later point, new point developments rooted in rigorous analytical models.
    Type of Medium: Online Resource
    ISSN: 1087-1357 , 1528-8935
    URL: Article
    DOI: 10.1115/1.1794160
    Language: English
    Publisher: ASME International
    Publication Date: 2005
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  • 3
    Online Resource
    Online Resource
    Influence of Replacing Molybdenum with Tungsten on the Creep Fracture Property of Waspaloy Nickel-Based Alloy
    MDPI AG ; 2022
    In:  Metals Vol. 12, No. 11 ( 2022-10-28), p. 1842-
    Details
    In: Metals, MDPI AG, Vol. 12, No. 11 ( 2022-10-28), p. 1842-
    Abstract: Alloys meeting the requirements of “700 °C and above” advanced ultra-super-critical technology, with higher thermal efficiency, have been developed in recent years. Here, a new wrought Ni-based superalloy with excellent high-temperature creep strength based on Waspaloy has been developed and is proposed as a candidate material for application in 700 °C class advanced ultra-super-critical steam turbine blades. In this new alloy, the Molybdenum (Mo) in Waspaloy is partially replaced by Tungsten (W). Creep tests have shown that this new Ni-based alloy has a 70 MPa higher creep-rupture strength than that of Waspaloy at 700 °C by extrapolating the experimental data. Detailed creep-rupture mechanisms have been analyzed by means of scanning electron microscopy, transmission electron microscopy, and chemical phase analysis with a view to devising potential approaches for performance improvements. The results showed that the partial replacement of Mo by W had negligible effect on the composition of carbides precipitated in the alloy. Instead, the amount of the γ′ phase was significantly increased, and mismatch between the γ and γ′ phases was reduced. In this way, the stability of the γ′ phase was increased, its coarsening rate was reduced, and its critical shear stress was increased. As a result, the high-temperature creep-fracture strength of the new alloy was increased.
    Type of Medium: Online Resource
    ISSN: 2075-4701
    URL: Article
    DOI: 10.3390/met12111842
    Language: English
    Publisher: MDPI AG
    Publication Date: 2022
    detail.hit.zdb_id: 2662252-X
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  • 4
    Online Resource
    Online Resource
    Deciphering the biodiversity of Listeria monocytogenes lineage III strains by polyphasic approaches
    Springer Science and Business Media LLC ; 2011
    In:  The Journal of Microbiology Vol. 49, No. 5 ( 2011-10), p. 759-767
    Details
    In: The Journal of Microbiology, Springer Science and Business Media LLC, Vol. 49, No. 5 ( 2011-10), p. 759-767
    Type of Medium: Online Resource
    ISSN: 1225-8873 , 1976-3794
    URL: Article
    DOI: 10.1007/s12275-011-1006-4
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2011
    detail.hit.zdb_id: 2441367-7
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  • 5
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    Online Resource
    Table2.DOCX
    Frontiers Media SA ; 2021
    In:  Frontiers in Bioengineering and Biotechnology Vol. 9 ( 2021-9-8)
    Details
    In: Frontiers in Bioengineering and Biotechnology, Frontiers Media SA, Vol. 9 ( 2021-9-8)
    Abstract: Regenerative endodontic procedures using autologous platelet-rich plasma (PRP) can improve the biologic outcome of treatment. However, its mechanism of action on improving pulp regeneration is not fully elucidated. Autophagy was recently shown to be related to tissue repair and osteogenesis. Therefore, the objective of this study was to investigate the effect of PRP in dental pulp regeneration and to elucidate the role of autophagy involved in this process. Human dental pulp cells (hDPCs) were isolated from healthy dental pulp and co-cultured with an increasing concentration of PRP. Cellular migration and proliferation were determined by scratch assay, transwell assay, and cell-counting kit 8 assay. Osteogenic differentiation was clarified by using alkaline phosphatase staining, alizarin red staining, and real-time polymerase chain reaction (RT-PCR) to measure the gene expression levels of alkaline phosphatase, collagen-1, osteocalcin, dentin matrix protein 1, and dentin sialophosphoprotein. Autophagic bodies were observed by transmission electron microscopy and the expression of autophagy marker light chain 3B (LC3B) was determined by immunofluorescence staining. The mRNA and protein expression level of LC3B and Beclin-1 were quantified by qRT-PCR and western blotting. The effect of PRP on cellular migration, proliferation, and osteogenic differentiation was further investigated in the milieu of autophagy activator, rapamycin, and inhibitor, 3-methyladenine. Results showed that PRP promoted cell migration, proliferation, and osteogenic differentiation. Autophagic bodies were strongly activated and the expression level of LC3B and Beclin-1 was significantly promoted by PRP. Autophagy inhibition suppressed PRP-induced hDPCs migration, proliferation, and osteogenic differentiation, whereas autophagy activator substantially augmented PRP-stimulated migration, proliferation, and differentiation. Taken together, these findings suggested that PRP could effectively promote regenerative potentials associated with autophagy.
    Type of Medium: Online Resource
    ISSN: 2296-4185
    URL: Article
    URL: Article
    URL: Article
    DOI: 10.3389/fbioe.2021.659742
    DOI: 10.3389/fbioe.2021.659742.s001
    DOI: 10.3389/fbioe.2021.659742.s002
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2021
    detail.hit.zdb_id: 2719493-0
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  • 6
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    Online Resource
    Knockdown of insulin-like growth factor 2 gene disrupts mitochondrial functions in the liver
    Oxford University Press (OUP) ; 2021
    In:  Journal of Molecular Cell Biology ( 2021-05-14)
    Details
    In: Journal of Molecular Cell Biology, Oxford University Press (OUP), ( 2021-05-14)
    Abstract: Even though insulin-like growth factor 2 (IGF2) has been reported to be overexpressed in nonalcoholic fatty liver disease (NAFLD), its role in the progression of NAFLD and the potential mechanism remain largely unclear. Using in vitro models, we found that IGF2 was the key overexpressed gene in steatosis, suggesting a possible association between IGF2 and NAFLD. Interestingly, loss-of-function experiments revealed that inhibition of IGF2 protein impaired mitochondrial biogenesis and respiration. It additionally disrupted the expression changes of mitochondrial fusion and fission-related proteins necessary in maintaining mitochondrial homeostasis. Consistently, IGF2 knockdown reduced the mitochondrial membrane potential and increased the production of reactive oxygen species. Mechanistically, IGF2 regulates mitochondrial functions by modulating the expression of SIRT1 and its downstream gene PGC1α. This research opens a new Frontier on the role of IGF2 in energy metabolism, which potentially participates in the development of NAFLD. As such, IGF2 is a potential therapeutic target against NAFLD.
    Type of Medium: Online Resource
    ISSN: 1674-2788 , 1759-4685
    URL: Article
    DOI: 10.1093/jmcb/mjab030
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2021
    detail.hit.zdb_id: 2500949-7
    SSG: 12
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  • 7
    Online Resource
    Online Resource
    Topology of Spade Drills for Wood Drilling Operations Part 2: Spade Drill Point Cutting Geometry Analysis
    ASME International ; 2005
    In:  Journal of Manufacturing Science and Engineering Vol. 127, No. 2 ( 2005-05-01), p. 310-318
    Details
    In: Journal of Manufacturing Science and Engineering, ASME International, Vol. 127, No. 2 ( 2005-05-01), p. 310-318
    Abstract: Based on the spade drill point’s mathematical models established in Part 1 of this paper, a detailed methodology for the analysis of the cutting edges and angle distributions along these edges is given. The analysis addresses the most important geometric elements of the bit including the tip, major cutting edge, and the chisel edge profiles, as well as the rake and clearance angle distribution along these cutting edges. In unison, the geometric model of the spade bit and the analysis procedure described in this part of the paper have laid the foundation for a methodology and a software package for a detailed geometric analysis of all relevant cutting mechanics related geometric entities of the drill. This, in turn, constitutes the first prerequisite for assessing the cutting performance of these tools.
    Type of Medium: Online Resource
    ISSN: 1087-1357 , 1528-8935
    URL: Article
    DOI: 10.1115/1.1794161
    Language: English
    Publisher: ASME International
    Publication Date: 2005
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  • 8
    Online Resource
    Online Resource
    Mechanistic Model for Spade Drills for Wood Drilling Operations, Part 2: Analysis of Spade Bit Geometry and Performance
    ASME International ; 2003
    In:  Journal of Manufacturing Science and Engineering Vol. 125, No. 2 ( 2003-05-01), p. 236-244
    Details
    In: Journal of Manufacturing Science and Engineering, ASME International, Vol. 125, No. 2 ( 2003-05-01), p. 236-244
    Abstract: In this part of the paper the analytical models for the prediction of the force system, established in Part 1, in conjunction with a complete geometric model of the spade bit, will be used in a systematic simulation analysis of the spade drill’s performance. The aim of this analysis is to identify the most desirable geometric characteristics of the different topological features of the spade bit that would result in desirable performance measures expressed in terms of reduced torque and thrust force. The obtained results are intended to guide the development of more efficient tools of this type.
    Type of Medium: Online Resource
    ISSN: 1087-1357 , 1528-8935
    URL: Article
    DOI: 10.1115/1.1559157
    Language: English
    Publisher: ASME International
    Publication Date: 2003
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  • 9
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    Identification of Residues Controlling Restriction versus Enhancing Activities of IFITM Proteins on Entry of Human Coronaviruses
    American Society for Microbiology ; 2018
    In:  Journal of Virology Vol. 92, No. 6 ( 2018-03-15)
    Details
    In: Journal of Virology, American Society for Microbiology, Vol. 92, No. 6 ( 2018-03-15)
    Abstract: Interferon-induced transmembrane proteins (IFITMs) are restriction factors that inhibit the infectious entry of many enveloped RNA viruses. However, we demonstrated previously that human IFITM2 and IFITM3 are essential host factors facilitating the entry of human coronavirus (HCoV) OC43. In a continuing effort to decipher the molecular mechanism underlying IFITM differential modulation of HCoV entry, we investigated the roles of structural motifs important for IFITM protein posttranslational modifications, intracellular trafficking, and oligomerization in modulating the entry of five HCoVs. We found that three distinct mutations in IFITM1 or IFITM3 converted the host restriction factors to enhance entry driven by the spike proteins of severe acute respiratory syndrome coronavirus (SARS-CoV) and/or Middle East respiratory syndrome coronavirus (MERS-CoV). First, replacement of IFITM3 tyrosine 20 with either alanine or aspartic acid to mimic unphosphorylated or phosphorylated IFITM3 reduced its activity to inhibit the entry of HCoV-NL63 and -229E but enhanced the entry of SARS-CoV and MERS-CoV. Second, replacement of IFITM3 tyrosine 99 with either alanine or aspartic acid reduced its activity to inhibit the entry of HCoV-NL63 and SARS-CoV but promoted the entry of MERS-CoV. Third, deletion of the carboxyl-terminal 12 amino acid residues from IFITM1 enhanced the entry of MERS-CoV and HCoV-OC43. These findings suggest that these residues and structural motifs of IFITM proteins are key determinants for modulating the entry of HCoVs, most likely through interaction with viral and/or host cellular components at the site of viral entry to modulate the fusion of viral envelope and cellular membranes. IMPORTANCE The differential effects of IFITM proteins on the entry of HCoVs that utilize divergent entry pathways and membrane fusion mechanisms even when using the same receptor make the HCoVs a valuable system for comparative investigation of the molecular mechanisms underlying IFITM restriction or promotion of virus entry into host cells. Identification of three distinct mutations that converted IFITM1 or IFITM3 from inhibitors to enhancers of MERS-CoV or SARS-CoV spike protein-mediated entry revealed key structural motifs or residues determining the biological activities of IFITM proteins. These findings have thus paved the way for further identification of viral and host factors that interact with those structural motifs of IFITM proteins to differentially modulate the infectious entry of HCoVs.
    Type of Medium: Online Resource
    ISSN: 0022-538X , 1098-5514
    URL: Article
    DOI: 10.1128/JVI.01535-17
    Language: English
    Publisher: American Society for Microbiology
    Publication Date: 2018
    detail.hit.zdb_id: 1495529-5
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  • 10
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    Online Resource
    Prognostic value of combined inflammatory and nutritional biomarkers in HCC within the Milan criteria after hepatectomy
    Frontiers Media SA ; 2022
    In:  Frontiers in Oncology Vol. 12 ( 2022-9-5)
    Details
    In: Frontiers in Oncology, Frontiers Media SA, Vol. 12 ( 2022-9-5)
    Abstract: This study aimed to evaluate the predictive value of the combined prognostic nutritional index (PNI) and GGT/ALT for the postoperative prognosis of patients with hepatocellular carcinoma (HCC) within Milan criteria undergoing radical hepatectomy. Methods This single-center retrospective study included 283 patients with HCC within the Milan criteria who underwent hepatectomy. The receiver operating characteristic (ROC) curve was used to calculate the optimal PNI and GGT/ALT cut-off values. Pre-treatment PNI, GGT/ALT, and PNI-GGT/ALT grades were calculated. Overall survival (OS) and recurrence-free survival (RFS) were estimated using the Kaplan–Meier method, and multivariate analysis was used to identify prognostic factors. Results Multivariate Cox regression analysis identified that the PNI, GGT/ALT, tumor number were significant prognostic markers for OS, and that the GGT/ALT, tumor number were significant prognostic markers for OS. The survival curves showed that low PNI, high GGT/ALT ratio, and high PNI-GGT/ALT grade were associated with poorer OS and DFS. With an area under the curve (AUC) of 0.690, PNI-GGT/ALT outperformed each individual score. Conclusion PNI-GGT/ALT, a new prognostic scoring model, qualifies as a novel prognostic predictor for patients with HCC within the Milan criteria after curative resection.
    Type of Medium: Online Resource
    ISSN: 2234-943X
    URL: Article
    DOI: 10.3389/fonc.2022.947302
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2022
    detail.hit.zdb_id: 2649216-7
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