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  • 1
    Online Resource
    Online Resource
    Comprehensive genomic profile of Chinese lung cancer patients and mutation characteristics of individuals resistant to icotinib/gefitinib
    Springer Science and Business Media LLC ; 2020
    In:  Scientific Reports Vol. 10, No. 1 ( 2020-11-20)
    Details
    In: Scientific Reports, Springer Science and Business Media LLC, Vol. 10, No. 1 ( 2020-11-20)
    Abstract: Lung cancer is the leading causes of cancer-related death worldwide. Precise treatment based on next-generation sequencing technology has shown advantages in the diagnosis and treatment of lung cancer. This cohort study included 371 lung cancer patients. The lung cancer subtype was related to the smoking status and sex of the patients. The most common mutated genes were TP53 (62%), EGFR (55%), and KRAS (11%). The mutation frequencies of EGFR , TP53 , PIK3CA , NFE2L2 , KMT2D , FGFR1 , CCND1 , and CDKN2A were significantly different between lung adenocarcinoma and lung squamous cell carcinoma. We identified the age-associated mutations in ALK , ERBB2 , KMT2D , RBM10 , NRAS , NF1 , PIK3CA , MET , PBRM1 , LRP2 , and CDKN2B ; smoking-associated mutations in CDKN2A , FAT1 , FGFR1 , NFE2L2 , CCNE1 , CCND1 , SMARCA4 , KEAP1 , KMT2C , and STK11 ; tumor stage-associated mutations in ARFRP1 , AURKA , and CBFB ; and sex-associated mutations in EGFR . Tumor mutational burden (TMB) is associated with tumor subtype, age, sex, and smoking status. TMB-associated mutations included CDKN2A , LRP1B , LRP2 , TP53 , and EGFR . EGFR amplification was commonly detected in patients with acquired lcotinib/gefitinib resistance. DNMT3A and NOTCH4 mutations may be associated with the benefit of icotinib/gefitinib treatment.
    Type of Medium: Online Resource
    ISSN: 2045-2322
    URL: Article
    DOI: 10.1038/s41598-020-76791-y
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2020
    detail.hit.zdb_id: 2615211-3
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  • 2
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    Prevalence of Dysphagia in China: An Epidemiological Survey of 5943 Participants
    Springer Science and Business Media LLC ; 2021
    In:  Dysphagia Vol. 36, No. 3 ( 2021-06), p. 339-350
    Details
    In: Dysphagia, Springer Science and Business Media LLC, Vol. 36, No. 3 ( 2021-06), p. 339-350
    Type of Medium: Online Resource
    ISSN: 0179-051X , 1432-0460
    URL: Article
    DOI: 10.1007/s00455-020-10138-7
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2021
    detail.hit.zdb_id: 1459017-7
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  • 3
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    Switching Immunosuppression From Cyclosporine to Tacrolimus in Kidney Transplant Recipients Based on CYP3A5 Genotyping
    Ovid Technologies (Wolters Kluwer Health) ; 2019
    In:  Therapeutic Drug Monitoring Vol. 41, No. 1 ( 2019-02), p. 97-101
    Details
    In: Therapeutic Drug Monitoring, Ovid Technologies (Wolters Kluwer Health), Vol. 41, No. 1 ( 2019-02), p. 97-101
    Abstract: Kidney transplant recipients on long-term cyclosporine (CsA) therapy may develop multiple adverse drug events, and immunosuppression conversion from CsA to tacrolimus (Tac) is an option. Genetic variations, especially cytochrome P450 ( CYP ) 3A5*3 , affects Tac dosing. However, little information is available to guide the conversion with regards to patients' pharmacogenomics. We aimed to investigate whether CYP3A5 , CYP3A4 , and ABCB1 genotyping could contribute to a more precise and individualized initial dosing of Tac at the time of immunosuppressant conversion. Methods: Genotypes of 5 candidate genes ( CYP3A5*3 , CYP3A4*1G , ABCB1C1236T , ABCB1C3435T , and ABCB1G2677T/A ) were investigated by polymerase chain reaction and restriction fragment-length polymorphism methods in 46 adult kidney transplant recipients requiring immunosuppressant conversion from CsA to TAC. Associations between these functional genetic polymorphisms and the dose-adjusted trough concentrations of CsA and Tac were evaluated, retrospectively. Results: Based on the linear regression analysis, CYP3A5 expressers (*1/*1 and *1/*3) had lower Tac dose-adjusted trough concentrations on days 7, 14, 21, and 28, and they required 1.40- to 1.75-fold higher daily dose to reach the target concentration compared with nonexpressers (*3/*3) on day 28 [0.07 (0.06–0.09) mg/kg/d versus 0.05 (0.02–0.06) mg/kg/d, P = 0.001]. CYP3A4*1G or ABCB1 genetic polymorphisms had no effect on the Tac dose-adjusted trough concentrations. Conclusions: Our preliminary study supports the use of CYP3A5 genotyping to guide the initial dosing of Tac when converting the immunosuppression therapy from CsA to Tac.
    Type of Medium: Online Resource
    ISSN: 0163-4356
    URL: Article
    DOI: 10.1097/FTD.0000000000000579
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2019
    detail.hit.zdb_id: 2048919-5
    SSG: 15,3
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  • 4
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    Table_1.DOCX
    Frontiers Media SA ; 2022
    In:  Frontiers in Public Health Vol. 9 ( 2022-1-12)
    Details
    In: Frontiers in Public Health, Frontiers Media SA, Vol. 9 ( 2022-1-12)
    Abstract: Purpose: Physical examination is a key component of child health management. Migrant children are a vulnerable group with lower healthcare service utilization, and this study aims to explore the effect of parental social integration on the physical examination service utilization for young migrant children under 6 years old in China. Method: This study conducted a secondary data analysis of the 2014 National Internal Migrant Dynamic Monitoring Survey in China. A total of 2,620 participants were included in this study. A total of 22 indicators were selected to measure social integration. Multivariate logistic regression was used to explore the association between parental social integration and physical examination use of young migrant children. Results: More than half (66.4%) of the migrant children aged 0–6 years had used free physical examination. Parental social integration, especially structural integration, was associated with the physical examination utilization of migrant children. Specifically, those migrant children's parents who had medical insurance ( P & lt; 0.05; OR = 1.29), who had participated in local activities ( P & lt; 0.001; OR = 1.98), who had registered local residents as neighbors ( P & lt; 0.05; OR = 1.34), and who had a deep sense of self-identity ( P & lt; 0.05; OR = 1.09) were more likely to take children to use physical examination. Conclusions: This study provided evidence that parental social integration was associated with migrant children's physical examination utilization, and this association was multifaceted, lying in the dimensions of economic, structural, and psychological integration. Improving the social integration of migrant parents would be effective to enhance the migrant children's healthcare service utilization.
    Type of Medium: Online Resource
    ISSN: 2296-2565
    URL: Article
    URL: Article
    DOI: 10.3389/fpubh.2021.755726
    DOI: 10.3389/fpubh.2021.755726.s001
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2022
    detail.hit.zdb_id: 2711781-9
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  • 5
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    Table_5.XLSX
    Frontiers Media SA ; 2022
    In:  Frontiers in Microbiology Vol. 13 ( 2022-3-17)
    Details
    In: Frontiers in Microbiology, Frontiers Media SA, Vol. 13 ( 2022-3-17)
    Abstract: Klebsiella pneumoniae exhibits extensive phenotypic and genetic diversity. Higher plasmid loads in the cell were supposed to play an key role in its genome diversity. Although some plasmids are widely distributed in Kp populations, they are poorly recognized. A plasmid named p2 in strain Kp1604 was predicted to be an intact prophage like Salmonella phage SSU5. However, our study showed that p2 was specifically packaged into membrane vesicles (MVs) rather than phage particles triggered by mitomycin C and subinhibitory concentrations of antibiotics. p2-minus mutant Kp1604 Δ p2 did not affect MV production. Compared with Kp1604 , the capacity of plasmid uptake and the amount of phage burst of Kp1604 Δ p2 were improved. Moreover, virulence of Kp1604 Δ p2 also increased. Our results indicated that p2 could contribute to the host defense against the invasion of transferable DNA elements at the cost of reduced virulence. Further study on the mechanism will help us understand how it provides adaptive phenotypes to host evolution.
    Type of Medium: Online Resource
    ISSN: 1664-302X
    URL: Article
    URL: Article
    URL: Article
    URL: Article
    URL: Article
    URL: Article
    URL: Article
    DOI: 10.3389/fmicb.2022.827545
    DOI: 10.3389/fmicb.2022.827545.s001
    DOI: 10.3389/fmicb.2022.827545.s002
    DOI: 10.3389/fmicb.2022.827545.s003
    DOI: 10.3389/fmicb.2022.827545.s004
    DOI: 10.3389/fmicb.2022.827545.s005
    DOI: 10.3389/fmicb.2022.827545.s006
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2022
    detail.hit.zdb_id: 2587354-4
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  • 6
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    DataSheet1.DOCX
    Frontiers Media SA ; 2023
    In:  International Journal of Public Health Vol. 68 ( 2023-2-14)
    Details
    In: International Journal of Public Health, Frontiers Media SA, Vol. 68 ( 2023-2-14)
    Abstract: Objectives: Vaccine literacy (VL) is an essential component of health literacy and is regarded as the promising technique for eliminating vaccine hesitancy. This review summarizes the relationship between VL and vaccination, including vaccine hesitancy, vaccination attitude, vaccination intention, and vaccination uptake. Methods: A systematic search was conducted in the PubMed, Embase, Web of Science, CINAHL, PsycINFO, and Cochrane Library databases. Studies that explored the relationship between VL and vaccination were included, and the PRISMA recommendations were followed. Results: 1523 studies were found, and 21 articles were selected. The earliest article was published in 2015 and focused on the HPV vaccination and VL of female college students. Three studies surveyed parents’ VL about childhood vaccinations, and the remaining 17 focused on COVID-19 VL in different groups. Conclusion: Although VL plays a role in determining the level of vaccine hesitancy across various populations, the association remains unclear. In the future, additional assessment methods could be developed and used to conduct prospective cohort and longitudinal studies to determine the causal relationship between VL and vaccination.
    Type of Medium: Online Resource
    ISSN: 1661-8564
    URL: Article
    URL: Article
    DOI: 10.3389/ijph.2023.1605606
    DOI: 10.3389/ijph.2023.1605606.s001
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2023
    detail.hit.zdb_id: 2276416-1
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  • 7
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    Abstract 5754: The molecular characteristics of EGFR co-mutations in lung adenocarcinoma
    American Association for Cancer Research (AACR) ; 2022
    In:  Cancer Research Vol. 82, No. 12_Supplement ( 2022-06-15), p. 5754-5754
    Details
    In: Cancer Research, American Association for Cancer Research (AACR), Vol. 82, No. 12_Supplement ( 2022-06-15), p. 5754-5754
    Abstract: Background: With the development of sensitive next-generation sequencing (NGS) techniques that go beyond the genotyping of specific mutations, detection rates for uncommon mutations have risen clinically. Given this rise in mutation identification, discoveries regarding isolation or coexistent mutations with the EGFR mutation (termed a “complex” mutation) are in “uncharted territory” in terms of their biological impacts on oncogenic pathways and their sensitivity or resistance, to EGFR TKIs. Methods: Targeted NGS for 450 genes was performed in OrigiMed (Shanghai, China), a College of American Pathologists (CAP) accredited and Clinical Laboratory Improvement Amendments (CLIA) certified laboratory. Results: A cohort of 262 Chinese lung adenocarcinoma patients were recruited. The most common mutated gene was EGFR (63%, 165/262), and followed by TP53 gene (59.2%, 155/262). Beyond single genetic lesions, we found that enriched co-mutations in lung adenocarcinoma were significantly different for TP53 (p & lt; 0.001) and RTK-RAS (p = 0.0012) signaling pathways between the EGFR-positive and EGFR-negative groups. In all EGFR co-mutated patients, the frequency of co-mutation for EGFR/TP53 and the classical EGFR mutation was 106 (64.2%) and 144 (87.3%), respectively. EGFR-only mutations occurred in 50 (30.3%) patients, while co-mutation of EGFR and at least one tumor suppressor gene (TSG) occurred in 84 (50.9%) patients. Patients with EGFR-only mutation had a lower tumor mutational burden (p = 0.026) as compared to patients with only a TSG mutation. Patients with co-mutations of EGFR and at least one TSG also displayed a lower tumor mutational burden, although only a slight difference (p = 0.062) was determined. Conclusions: Profiles of EGFR co-mutational TSGs should be regarded as a unique subgroup for predictive insights in treatments for patients with co-occurrence of somatic EGFR and TSG mutations. To improve predictions related to drug sensitivity in targeted therapies for oncogenes with diverse mutations, our future studies will include publications dedicated to this topic. Citation Format: Yanhong Shang, Hao Zhang, Aiming Zang, Shaohua Yuan, Xiaofang Li, Wenpan Zhang, Ran Huo, Guotao Fang, Zhengyue Dou, Weiwei Liu, Xiao Han, Qi Zhao, Chenglin Xi. The molecular characteristics of EGFR co-mutations in lung adenocarcinoma [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr 5754.
    Type of Medium: Online Resource
    ISSN: 1538-7445
    URL: Article
    DOI: 10.1158/1538-7445.AM2022-5754
    Language: English
    Publisher: American Association for Cancer Research (AACR)
    Publication Date: 2022
    detail.hit.zdb_id: 2036785-5
    detail.hit.zdb_id: 1432-1
    detail.hit.zdb_id: 410466-3
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  • 8
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    Influence of SiO2 glass phase (SGP) content on the oxidation and diffusion behavior of MoSi2 coatings on Nb-based alloys
    Elsevier BV ; 2022
    In:  Corrosion Science Vol. 203 ( 2022-07), p. 110372-
    Details
    In: Corrosion Science, Elsevier BV, Vol. 203 ( 2022-07), p. 110372-
    Type of Medium: Online Resource
    ISSN: 0010-938X
    URL: Article
    DOI: 10.1016/j.corsci.2022.110372
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2022
    detail.hit.zdb_id: 217269-0
    detail.hit.zdb_id: 1500558-6
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  • 9
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    Analysis of consumption sum and frequency of medication of new dosage forms in Changhai Hospital，Second Military Medical University from 2004 to 2013
    Publishing House of Pharmaceutical Care and Research ; 2014
    In:  Pharmaceutical Care and Research Vol. 2014, No. 04 ( 2014-08-30), p. 286-289
    Details
    In: Pharmaceutical Care and Research, Publishing House of Pharmaceutical Care and Research, Vol. 2014, No. 04 ( 2014-08-30), p. 286-289
    Type of Medium: Online Resource
    ISSN: 1671-2838
    URL: Issue
    URL: Journal
    URL: Article
    DOI: 10.5428/pcar201404
    DOI: 10.5428/pcar
    DOI: 10.5428/pcar20140416
    Language: Unknown
    Publisher: Publishing House of Pharmaceutical Care and Research
    Publication Date: 2014
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  • 10
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    Data_Sheet_1.zip
    Frontiers Media SA ; 2022
    In:  Frontiers in Public Health Vol. 10 ( 2022-9-14)
    Details
    In: Frontiers in Public Health, Frontiers Media SA, Vol. 10 ( 2022-9-14)
    Abstract: This study aims to clarify the profiles of the psychological antecedents of vaccine hesitancy among Shanghai nurses with a person-centered approach. Methods A population-based cross-sectional online survey was conducted on Shanghai nurses from July to August 2021 ( N = 1,928). In the online survey, participants were asked to report their sociodemographic, the 5C vaccine hesitancy components, their knowledge level of COVID-19 vaccine and vaccination, and the COVID-19 vaccination uptake intention and attention to vaccine news. Latent profile analysis was used to reveal distinct profiles of vaccine hesitancy. Results The results revealed four profiles, including “believers” (68.9%; high confidence and collective responsibility), “free riders” (12.7%; similar characteristics to believers, except for a low collective responsibility), “middlemen” (14.6%; middle in all 5C constructs), and “contradictors” (3.7%; high in all 5C constructs). Compared to believers, middlemen were younger, more likely to be female, childless, less educated, held lower professional titles, had fewer years of nursing service, sometimes or never complied with recommended vaccinations, had satisfactory or poor self-assessed health status, had no work experience during the COVID-19 epidemic, and possessed greater levels of knowledge. Free riders were more likely to work in community health centers and have a lower degree than believers. Contradictors were more likely to work in community health centers, had junior college degrees or lower, and had no work experience during the COVID-19 epidemic than believers. From the highest to the lowest on vaccination intention and attention to vaccine news were believers, then free riders, contradictors, and finally middlemen. Conclusion This study could aid in the development of personalized vaccination strategies based on nurses' vaccine hesitancy profiles and predictors. In addition to vaccine believers, we identified other three profiles based on their 5C psychological antecedents, emphasizing the significance of establishing tailored vaccination campaigns. Further research into the prevalence of profile structure in other groups of healthcare workers is required.
    Type of Medium: Online Resource
    ISSN: 2296-2565
    URL: Article
    URL: Article
    DOI: 10.3389/fpubh.2022.953850
    DOI: 10.3389/fpubh.2022.953850.s001
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2022
    detail.hit.zdb_id: 2711781-9
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