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  • 1
    Online Resource
    Online Resource
    Figure 4 from: Mou C, Wu Y, Xiang L, Xiang X-M, Zhang D-G (2020) Lysimachia xiangxiensis (Primulaceae), a new species from limestone area in Hunan Province, central China. PhytoKeys 140: 23-32. https://doi.org/10.3897/phytokeys.140.47995
    Pensoft Publishers ; 2020
    In:  PhytoKeys Vol. 140 ( 2020-02-24), p. 23-32
    Details
    In: PhytoKeys, Pensoft Publishers, Vol. 140 ( 2020-02-24), p. 23-32
    Abstract: A new species of Lysimachia , L. xiangxiensis (Primulaceae), is described and illustrated from western Hunan, central China. The species is similar to L. melampyroides in plant densely strigillose, leaves subglabrous adaxially, and flowers usually solitary in axils of upper leaves, but differs by the succulent leaves, the creeping or ascending stems 15–25 cm long, and the suborbicular to broadly elliptic corolla lobes. This new species is also supported by a molecular phylogenetic analysis of some Lysimachia species based on ITS sequence data.
    Type of Medium: Online Resource
    ISSN: 1314-2003 , 1314-2011
    URL: Article
    URL: Article
    URL: Article
    URL: Article
    URL: Article
    DOI: 10.3897/phytokeys.140.47995
    DOI: 10.3897/phytokeys.140.47995.figure1
    DOI: 10.3897/phytokeys.140.47995.figure2
    DOI: 10.3897/phytokeys.140.47995.figure3
    DOI: 10.3897/phytokeys.140.47995.figure4
    Language: Unknown
    Publisher: Pensoft Publishers
    Publication Date: 2020
    detail.hit.zdb_id: 2579891-1
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  • 2
    Online Resource
    Online Resource
    The role of nutrition in analysis of risk factors and short-term outcomes for late-onset necrotizing enterocolitis among very preterm infants: a nationwide, multicenter study in China
    Springer Science and Business Media LLC ; 2024
    In:  BMC Pediatrics Vol. 24, No. 1 ( 2024-03-08)
    Details
    In: BMC Pediatrics, Springer Science and Business Media LLC, Vol. 24, No. 1 ( 2024-03-08)
    Abstract: Necrotizing enterocolitis (NEC) is a serious gastrointestinal disease, primarily affects preterm newborns and occurs after 7 days of life (late-onset NEC, LO-NEC). Unfortunately, over the past several decades, not much progress has been made in its treatment or prevention. This study aimed to analyze the risk factors for LO-NEC, and the impact of LO-NEC on short-term outcomes in very preterm infants (VPIs) with a focus on nutrition and different onset times. Method Clinical data of VPIs were retrospectively collected from 28 hospitals in seven different regions of China from September 2019 to December 2020. A total of 2509 enrolled VPIs were divided into 2 groups: the LO-NEC group and non-LO-NEC group. The LO-NEC group was divided into 2 subgroups based on the onset time: LO-NEC occurring between 8 ~ 14d group and LO-NEC occurring after 14d group. Clinical characteristics, nutritional status, and the short-term clinical outcomes were analyzed and compared among these groups. Results Compared with the non-LO-NEC group, the LO-NEC group had a higher proportion of anemia, blood transfusion, and invasive mechanical ventilation (IMV) treatments before NEC; the LO-NEC group infants had a longer fasting time, required longer duration to achieve the target total caloric intake (110 kcal/kg) and regain birthweight, and showed slower weight growth velocity; the cumulative dose of the medium-chain and long-chain triglyceride (MCT/LCT) emulsion intake in the first week after birth was higher and breastfeeding rate was lower. Additionally, similar results including a higher proportion of IMV, lower breastfeeding rate, more MCT/LCT emulsion intake, slower growth velocity were also found in the LO-NEC group occurring between 8 ~ 14d when compared to the LO-NEC group occurring after 14 d (all ( P   〈  0.05). After adjustment for the confounding factors, high proportion of breastfeeding were identified as protective factors and long fasting time before NEC were identified as risk factors for LO-NEC; early feeding were identified as protective factors and low gestational age, grade III ~ IV neonatal respiratory distress syndrome (NRDS), high accumulation of the MCT/LCT emulsion in the first week were identified as risk factors for LO-NEC occurring between 8 ~ 14d. Logistic regression analysis showed that LO-NEC was a risk factor for late-onset sepsis, parenteral nutrition-associated cholestasis, metabolic bone disease of prematurity, and extrauterine growth retardation. Conclusion Actively preventing premature birth, standardizing the treatment of grade III ~ IV NRDS, and optimizing enteral and parenteral nutrition strategies may help reduce the risk of LO-NEC, especially those occurring between 8 ~ 14d, which may further ameliorate the short-term clinical outcome of VPIs. Trial registration ChiCTR1900023418 (26/05/2019).
    Type of Medium: Online Resource
    ISSN: 1471-2431
    URL: Article
    DOI: 10.1186/s12887-024-04611-7
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2024
    detail.hit.zdb_id: 2041342-7
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  • 3
    Online Resource
    Online Resource
    Risk factors of extrauterine growth restriction in very preterm infants with bronchopulmonary dysplasia: a multi-center study in China
    Springer Science and Business Media LLC ; 2022
    In:  BMC Pediatrics Vol. 22, No. 1 ( 2022-12)
    Details
    In: BMC Pediatrics, Springer Science and Business Media LLC, Vol. 22, No. 1 ( 2022-12)
    Abstract: Nutritional deficiency soon after birth is a risk factor of chronic lung disease (bronchopulmonary dysplasia, BPD). Afflicted infants are further prone to inadequate growth during hospitalization (extrauterine growth restriction, EUGR). This multi-center retrospective study investigated risk factors of EUGR, specifically in very preterm infants with BPD. Method Data of infants with BPD who were born less than 32 weeks gestation ( n  = 1010) were collected from 7 regions of China. All infants were non-small for gestational age at birth. Infants were characterized as EUGR or non-EUGR at 36 weeks gestation or discharge, or stratified by gestational age or birthweight. Logistic regression analysis was applied. Results In 65.5% of the population, the BPD was mild. Infants with severe BPD (8.3%) had the highest rate of EUGR (72.6%, P   〈  0.001). Groups stratified by gestational age did not differ in rates of EUGR, but the birthweight of the EUGR group was significantly lower than that of the non-EUGR ( P   〈  0.001). Birthweights of  〈  1000, 1000–1499, and ≥ 1500 g showed EUGR rates of 65.9%, 43.4%, and 23.8%, respectively ( P   〈  0.001). Overall, the independent risk factors of EUGR were: moderate-to-severe BPD, gestational hypertension, cesarean section, cumulative fasting time, time required to achieve 110 kcal/kg/d, and hemodynamically significant patent ductus arteriosus (hsPDA). Conclusion In very preterm infants with BPD, the lower the birthweight or the more severe the BPD, the greater the risk of EUGR. In those with hsPDA, or moderate-to-severe BPD, it is especially important to prevent EUGR through perinatal management, enteral nutrition, and nutritional strategies.
    Type of Medium: Online Resource
    ISSN: 1471-2431
    URL: Article
    DOI: 10.1186/s12887-022-03405-z
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2022
    detail.hit.zdb_id: 2041342-7
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  • 4
    Online Resource
    Online Resource
    Construction of China national newborn growth standards based on a large low-risk sample
    Springer Science and Business Media LLC ; 2021
    In:  Scientific Reports Vol. 11, No. 1 ( 2021-08-09)
    Details
    In: Scientific Reports, Springer Science and Business Media LLC, Vol. 11, No. 1 ( 2021-08-09)
    Abstract: Most published newborn growth references are based on conventional monitoring data that usually included both low- and high-risk pregnancies. We sought to develop a set of neonatal growth standards constructed from only a large sample of low-risk pregnancies. A total of 24,375 naturally conceived singleton live births with gestational ages of 24–42 weeks were collected in 69 hospitals in thirteen Chinese cities between 2015 and 2018. Unhealthy infants or those with high-risk mother were excluded. Smoothed percentile curves of six anthropometric indicators were established using the Generalized Additive Model for Location, Scale and Shape. The 3rd, 10th, 25th, 50th, 75th, 90th, and 97th percentile references for birth weight, length, head circumference, weight/length, body mass index, and ponderal index were calculated for neonates with gestational ages of 24–42 weeks. This set of neonatal growth standards with six anthropometric indicators can provide more tools for growth and nutrition assessment and body proportionality in neonatal clinical practice. These standards might also help to show the differences between growth curves based on low-risk and mixed low- and high-risk pregnancies.
    Type of Medium: Online Resource
    ISSN: 2045-2322
    URL: Article
    DOI: 10.1038/s41598-021-94606-6
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2021
    detail.hit.zdb_id: 2615211-3
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  • 5
    Online Resource
    Online Resource
    Real-time predictive model of extrauterine growth retardation in preterm infants with gestational age less than 32 weeks
    Springer Science and Business Media LLC ; 2024
    In:  Scientific Reports Vol. 14, No. 1 ( 2024-06-05)
    Details
    In: Scientific Reports, Springer Science and Business Media LLC, Vol. 14, No. 1 ( 2024-06-05)
    Abstract: The aim of this study was to develop a real-time risk prediction model for extrauterine growth retardation (EUGR). A total of 2514 very preterm infants were allocated into a training set and an external validation set. The most appropriate independent variables were screened using univariate analysis and Lasso regression with tenfold cross-validation, while the prediction model was designed using binary multivariate logistic regression. A visualization of the risk variables was created using a nomogram, while the calibration plot and receiver operating characteristic (ROC) curves were used to calibrate the prediction model. Clinical efficacy was assessed using the decision curve analysis (DCA) curves. Eight optimal predictors that namely birth weight, small for gestation age (SGA), hypertensive disease complicating pregnancy (HDCP), gestational diabetes mellitus (GDM), multiple births, cumulative duration of fasting, growth velocity and postnatal corticosteroids were introduced into the logistic regression equation to construct the EUGR prediction model. The area under the ROC curve of the training set and the external verification set was 83.1% and 84.6%, respectively. The calibration curve indicate that the model fits well. The DCA curve shows that the risk threshold for clinical application is 0–95% in both set. Introducing Birth weight, SGA, HDCP, GDM, Multiple births, Cumulative duration of fasting, Growth velocity and Postnatal corticosteroids into the nomogram increased its usefulness for predicting EUGR risk in very preterm infants.
    Type of Medium: Online Resource
    ISSN: 2045-2322
    URL: Article
    DOI: 10.1038/s41598-024-63593-9
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2024
    detail.hit.zdb_id: 2615211-3
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  • 6
    Online Resource
    Online Resource
    Genome-wide association study identifies a novel susceptibility gene for serum TSH levels in Chinese populations
    Oxford University Press (OUP) ; 2014
    In:  Human Molecular Genetics Vol. 23, No. 20 ( 2014-10-15), p. 5505-5517
    Details
    In: Human Molecular Genetics, Oxford University Press (OUP), Vol. 23, No. 20 ( 2014-10-15), p. 5505-5517
    Type of Medium: Online Resource
    ISSN: 0964-6906 , 1460-2083
    URL: Article
    DOI: 10.1093/hmg/ddu250
    RVK:
    XA 10000
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2014
    detail.hit.zdb_id: 1474816-2
    detail.hit.zdb_id: 1108742-0
    SSG: 12
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  • 7
    Online Resource
    Online Resource
    MR-SFAMA-Q: A MAC Protocol based on Q-Learning for Underwater Acoustic Sensor Networks
    Angle Publishing Co., Ltd. ; 2024
    In:  電腦學刊 Vol. 35, No. 1 ( 2024-02), p. 051-063
    Details
    In: 電腦學刊, Angle Publishing Co., Ltd., Vol. 35, No. 1 ( 2024-02), p. 051-063
    Abstract: 〈p〉In recent years, with the rapid development of science and technology, many new technologies have made people’s exploration of the ocean deeper and deeper, and due to the requirements of national defense and marine development, the underwater acoustic sensor network (UASN) has been paid more and more attention. Nevertheless, the underwater acoustic channel has the properties of considerable propagation delay, limited bandwidth, and unstable network topology. In order to improve the performance of the medium access control (MAC) protocol in UASN, we propose a new MAC protocol based on the Slotted-FAMA of Multiple Reception (MR-SFAMA) protocol. The protocol uses the Q-Learning algorithm to optimize the multi-receiver handshake mechanism. The current state is judged according to the received node request, and the Q-table is established. Through the multi-round interaction between the node and the environment, the Q-table is continuously updated to obtain the optimal strategy and determine the optimal data transmission scheduling scheme. The reward function is set according to the total back-off time and frame error rate, which can reduce the packet loss rate during network data transmission while reducing the delay. In addition, the matching asynchronous operation and uniform random back-off algorithm are used to solve the problem of long channel idle time and low channel utilization. This new protocol can be well applied to unstable network topology. The simulation results show that the protocol performs better than Slotted-FAMA and MR-SFAMA regarding delay and normalized throughput.〈/p〉 〈p〉 〈/p〉
    Type of Medium: Online Resource
    ISSN: 1991-1599 , 1991-1599
    Uniform Title: MR-SFAMA-Q: A MAC Protocol based on Q-Learning for Underwater Acoustic Sensor Networks
    URL: Article
    DOI: 10.53106/199115992024023501004
    Language: Unknown
    Publisher: Angle Publishing Co., Ltd.
    Publication Date: 2024
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  • 8
    Online Resource
    Online Resource
    Clopidogrel Plus Aspirin vs Aspirin Alone in Patients With Acute Mild to Moderate Stroke : The ATAMIS Randomized Clinical Trial
    American Medical Association (AMA) ; 2024
    In:  JAMA Neurology Vol. 81, No. 5 ( 2024-05-01), p. 450-
    Details
    In: JAMA Neurology, American Medical Association (AMA), Vol. 81, No. 5 ( 2024-05-01), p. 450-
    Abstract: Dual antiplatelet therapy has been demonstrated to be superior to single antiplatelet in reducing recurrent stroke among patients with transient ischemic attack or minor stroke, but robust evidence for its effect in patients with mild to moderate ischemic stroke is lacking. Objective To evaluate whether dual antiplatelet therapy is superior to single antiplatelet among patients with mild to moderate ischemic stroke. Design, Setting, and Participants This was a multicenter, open-label, blinded end point, randomized clinical trial conducted at 66 hospitals in China from December 20, 2016, through August 9, 2022. The date of final follow-up was October 30, 2022. The analysis was reported on March 12, 2023. Of 3065 patients with ischemic stroke, 3000 patients with acute mild to moderate stroke within 48 hours of symptom onset were enrolled, after excluding 65 patients who did not meet eligibility criteria or had no randomization outcome. Interventions Within 48 hours after symptom onset, patients were randomly assigned to receive clopidogrel plus aspirin (n = 1541) or aspirin alone (n = 1459) in a 1:1 ratio. Main Outcomes and Measures The primary end point was early neurologic deterioration at 7 days, defined as an increase of 2 or more points in National Institutes of Health Stroke Scale (NIHSS) score, but not as a result of cerebral hemorrhage, compared with baseline. The superiority of clopidogrel plus aspirin to aspirin alone was assessed based on a modified intention-to-treat population, which included all randomized participants with at least 1 efficacy evaluation regardless of treatment allocation. Bleeding events were safety end points. Results Of the 3000 randomized patients, 1942 (64.6%) were men, the mean (SD) age was 65.9 (10.6) years, median (IQR) NIHSS score at admission was 5 (4-6), and 1830 (61.0%) had a stroke of undetermined cause. A total of 2915 patients were included in the modified intention-to-treat analysis. Early neurologic deterioration occurred in 72 of 1502 (4.8%) in the dual antiplatelet therapy group vs 95 of 1413 (6.7%) in the aspirin alone group (risk difference −1.9%; 95% CI, −3.6 to −0.2; P  = .03). Similar bleeding events were found between 2 groups. Conclusions and Relevance Among Chinese patients with acute mild to moderate ischemic stroke, clopidogrel plus aspirin was superior to aspirin alone with regard to reducing early neurologic deterioration at 7 days with similar safety profile. These findings indicate that dual antiplatelet therapy may be a superior choice to aspirin alone in treating patients with acute mild to moderate stroke. Trial Registration ClinicalTrials.gov Identifier: NCT02869009
    Type of Medium: Online Resource
    ISSN: 2168-6149
    URL: Article
    DOI: 10.1001/jamaneurol.2024.0146
    Language: English
    Publisher: American Medical Association (AMA)
    Publication Date: 2024
    detail.hit.zdb_id: 2702023-X
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  • 9
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    Online Resource
    Clinical guideline on magnetically controlled capsule gastroscopy (2021 edition)
    Wiley ; 2023
    In:  Journal of Digestive Diseases Vol. 24, No. 2 ( 2023-02), p. 70-84
    Details
    In: Journal of Digestive Diseases, Wiley, Vol. 24, No. 2 ( 2023-02), p. 70-84
    Abstract: With the development and generalization of endoscopic technology and screening, clinical application of magnetically controlled capsule gastroscopy (MCCG) has been increasing. In recent years, various types of MCCG are used globally. Therefore, establishing relevant guidelines on MCCG is of great significance. The current guidelines containing 23 statements were established based on clinical evidence and expert opinions, mainly focus on aspects including definition and diagnostic accuracy, application population, technical optimization, inspection process, and quality control of MCCG. The level of evidence and strength of recommendations were evaluated. The guidelines are expected to guide the standardized application and scientific innovation of MCCG for the reference of clinicians.
    Type of Medium: Online Resource
    ISSN: 1751-2972 , 1751-2980
    URL: Issue
    URL: Article
    DOI: 10.1111/cdd.v24.2
    DOI: 10.1111/1751-2980.13173
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2317117-0
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  • 10
    Online Resource
    Online Resource
    Real-world evidence regarding the growth of very premature infants with small for gestational age after birth: a multicenter survey in China
    Springer Science and Business Media LLC ; 2023
    In:  BMC Pediatrics Vol. 23, No. 1 ( 2023-08-31)
    Details
    In: BMC Pediatrics, Springer Science and Business Media LLC, Vol. 23, No. 1 ( 2023-08-31)
    Abstract: To analyze the real-world growth pattern of very premature infants (VPI) with small for gestational age (SGA) after birth by using the ΔZ value of weight at discharge. Methods The clinical data were collected from 28 hospitals in China from September 2019 to December 2020. They were divided into the EUGR(Extrauterine Growth Restriction) and the non-EUGR group according to the criterion of ΔZ value of weight at discharge  〈  –1.28. Results This study included 133 eligible VPI with SGA. Following the criterion of ΔZ value, the incidence of EUGR was 36.84% (49/133). The birth weight, the 5-min Apgar score, and the proportion of male infants in the EUGR group were lower ( P   〈  0.05). The average invasive ventilation time, cumulative duration of the administration of antibiotics, blood transfusion time, blood transfusion ratio, and total days of hospitalization were significantly higher in the EUGR group ( P   〈  0.05). In the EUGR group, several factors exhibited higher values (P  〈  0.05), including the initiation of enteral feeding, the volume of milk supplemented with human milk fortifier (HMF), the duration to achieve complete fortification, the cumulative duration of fasting, the duration to achieve full enteral feeding, the length of parenteral nutrition (PN), the number of days required to attain the desired total calorie intake and oral calorie intake, as well as the age at which birth weight was regained. The average weight growth velocity (GV) was significantly lower in the EUGR group ( P   〈  0.001). The incidences of patent ductus arteriosus with hemodynamic changes (hsPDA), neonatal necrotizing enterocolitis (NEC) stage≥ 2, late-onset sepsis (LOS), and feeding intolerance (FI) in the EUGR group were higher ( P   〈  0.05). Multivariate logistic regression analysis showed that birth weight, male, and GV were the protective factors, while a long time to achieve full-dose fortification, slow recovery of birth weight, and NEC stage ≥2 were the independent risk factors. Conclusion SGA in VPI can reflect the occurrence of EUGR more accurately by using the ΔZ value of weight at discharge. Enhancing enteral nutrition support, achieving prompt and complete fortification of breast milk, promoting greater GV, reducing the duration of birth weight recovery, and minimizing the risk of NEC can contribute to a decreased occurrence of EUGR. Trial registration CHICTR, ChiCTR1900023418. Registered 26/05/2019, http://www.chictr.org.cn .
    Type of Medium: Online Resource
    ISSN: 1471-2431
    URL: Article
    DOI: 10.1186/s12887-023-04245-1
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2023
    detail.hit.zdb_id: 2041342-7
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