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  • 1
    Online Resource
    Online Resource
    CD56briCD27+CD11b+/- NK Cells Mediated Remission of Agvhd Via Immunoregulation
    American Society of Hematology ; 2020
    In:  Blood Vol. 136, No. Supplement 1 ( 2020-11-5), p. 28-28
    Details
    In: Blood, American Society of Hematology, Vol. 136, No. Supplement 1 ( 2020-11-5), p. 28-28
    Abstract: Background: In our previous study CD56briCD27+CD11b+/- NK cells show the potential of the remission of aGvHD, while the mechanism behind it is still unknown. Here, three hypothesis have been proposed according to further pilot experiment and literature. Method: 74 samples of patients after allo-HSCT were collected in the affiliated hospital of Guizhou medical university. Immunomonitoring with respect to the phenotype and function of CD56briCD27+CD11b+/- NK cells was performed on rested peripheral blood mononuclear cells (PBMCs) using multiparametric flow cytometry. Furthermore, the western-blot has been performed to determine the expression of HO-1 protein in sorted CD56briCD27+CD11b+/- NK cells as well. Result: (1) Our result shows a positive correlation between CD56briCD27+CD11b+/- NK cells and Th22, Tfh as well as Th1 like Tfh cells. Interestingly, a dramatic higher expression of homing marker CD62L has been observed on CD56briCD27+CD11b+/- NK cells. Thus we hypothesis that the CD56briCD27+CD11b+/- NK cells may migrate into the lymphoid tissues and regulate the differentiation of naïve T cells. (2) On the other hand, an elevated percentage of NKG2D has been found on CD56briCD27+CD11b+/- NK cells in patients with aGvHD. Meanwhile a high expression of Fas and exhaustion markers have been observed on CD4+ and CD8+ T cells. These results suggest that T cells may be eliminated by CD56briCD27+CD11b+/- NK cells. (3) Besides, our work displays that the expression of Heme Oxygenase-1 (HO-1) in CD56briCD27+CD11b+/- NK cells positively correlated with the secretion of IL-10. Compared with the patients with aGvHD, a higher expression of HO-1 and IL-10 in CD56briCD27+CD11b+/- NK cells has been found in patients without aGvHD at day 30 after allo-HSCT . Conclusion: According to these findings, the CD56briCD27+CD11b+/- NK cells may result in the remission of aGvHD via immunoregulation by regulation of T cells and secretion of IL-10. Disclosures No relevant conflicts of interest to declare.
    Type of Medium: Online Resource
    ISSN: 0006-4971 , 1528-0020
    URL: Article
    DOI: 10.1182/blood-2020-141881
    RVK:
    XA 33000
    RVK:
    XA 10000
    Language: English
    Publisher: American Society of Hematology
    Publication Date: 2020
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  • 2
    Online Resource
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    Circ_0020123 plays an oncogenic role in non‐small cell lung cancer depending on the regulation of miR ‐512‐3p/ CORO1C
    Wiley ; 2022
    In:  Thoracic Cancer Vol. 13, No. 9 ( 2022-05), p. 1406-1418
    Details
    In: Thoracic Cancer, Wiley, Vol. 13, No. 9 ( 2022-05), p. 1406-1418
    Abstract: Non‐small cell lung cancer (NSCLC) is one of the leading causes responsible for cancer‐associated death globally. The aim of this study was to illustrate the function of circular RNA_0020123 (circ_0020123) in NSCLC progression and its associated mechanism. Methods RNA and protein expression was determined by reverse transcription‐quantitative polymerase chain reaction (RT‐qPCR) and western blot assay. Cell proliferation, migration, invasion, angiogenesis, apoptosis and autophagy were analyzed to assess the role of circ_0020123/microRNA‐512‐3p (miR‐512‐3p)/coronin 1C (CORO1C) axis in NSCLC cells. Tumorigenesis in nude mice was analyzed to determine the in vivo role of circ_0020123. The intermolecular target relation was confirmed by dual‐luciferase reporter and RNA immunoprecipitation (RIP) assays. Results Circ_0020123 expression was aberrantly upregulated in NSCLC tissues and cell lines. Circ_0020123 interference markedly restrained cell proliferation, migration, invasion, angiogenesis and autophagy and induced cell apoptosis of NSCLC cells. Circ_0020123 knockdown suppressed xenograft tumor growth in vivo. Circ_0020123 acted as a molecular sponge for miR‐512‐3p. Circ_0020123 silencing‐induced effects in NSCLC cells were largely reversed by the knockdown of miR‐512‐3p. miR‐512‐3p interacted with the 3′ untranslated region (3′UTR) of CORO1C. CORO1C overexpression largely reversed miR‐512‐3p accumulation‐induced influences in NSCLC cells. Circ_0020123 positively regulated CORO1C expression by sponging miR‐512‐3p in NSCLC cells. Conclusion Circ_0020123 aggravated NSCLC progression by binding to miR‐512‐3p to induce CORO1C expression, which provided new potential targets for the treatment of NSCLC.
    Type of Medium: Online Resource
    ISSN: 1759-7706 , 1759-7714
    URL: Issue
    URL: Article
    DOI: 10.1111/tca.v13.9
    DOI: 10.1111/1759-7714.14408
    Language: English
    Publisher: Wiley
    Publication Date: 2022
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  • 3
    Online Resource
    Online Resource
    Autoantibodies in association with subchorionic haematoma in early pregnancy
    Informa UK Limited ; 2021
    In:  Annals of Medicine Vol. 53, No. 1 ( 2021-01-01), p. 841-847
    Details
    In: Annals of Medicine, Informa UK Limited, Vol. 53, No. 1 ( 2021-01-01), p. 841-847
    Type of Medium: Online Resource
    ISSN: 0785-3890 , 1365-2060
    URL: Article
    DOI: 10.1080/07853890.2021.1936150
    Language: English
    Publisher: Informa UK Limited
    Publication Date: 2021
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  • 4
    Online Resource
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    Functional interaction of TCF4 with ATF5 to regulate the Wnt signaling pathway
    Elsevier BV ; 2003
    In:  Science Bulletin Vol. 48, No. 7 ( 2003-4), p. 668-672
    Details
    In: Science Bulletin, Elsevier BV, Vol. 48, No. 7 ( 2003-4), p. 668-672
    Type of Medium: Online Resource
    ISSN: 2095-9273 , 2095-9281
    URL: Article
    DOI: 10.1007/BF03325652
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2003
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    detail.hit.zdb_id: 2816140-3
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  • 5
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    Online Resource
    Association between blood lead levels and hyperlipidemiais: Results from the NHANES (1999–2018)
    Frontiers Media SA ; 2022
    In:  Frontiers in Public Health Vol. 10 ( 2022-9-9)
    Details
    In: Frontiers in Public Health, Frontiers Media SA, Vol. 10 ( 2022-9-9)
    Abstract: Research on the association between blood lead (Pb) and lipid biomarkers have yielded inconsistent results, and epidemiological studies on blood Pb levels and hyperlipidemia are scarce. The present study aimed to examine the association between blood Pb levels and hyperlipidemia in adults from the National Health and Nutrition Examination Survey (NHANES). Methods A total of 43,196 participants in the NHANES from 1999 to 2018 were included in the final analysis. Hyperlipidemia was determined based on the National Cholesterol Education Program guidelines. Blood Pb levels were assessed using inductively-coupled plasma mass spectrometry. Weighted multivariable logistic regression analysis and subgroup analysis were conducted to determine the correlation between blood Pb levels and hyperlipidemia. Results In the multivariable logistic regression model, high blood Pb levels were significantly associated with hyperlipidemia after adjusting for confounders (OR 1.41; 95%CI: 1.18–1.67). Furthermore, elevated blood Pb levels were associated with an increased risk of hyperlipidemia across the four quartile (Q) groups (Q1: OR 1.00; Q2: OR 1.16 [95%CI: 1.04–1.29] ; Q3: OR 1.39 [95%CI: 1.21–1.59]; and Q4: OR 1.33 [95%CI: 1.15–1.54] ; P for trend & lt;0.05). Significant moderating effects were found in the subgroup analysis stratified by age, education, hypertension, and diabetes ( P & lt; 0.05). In sensitivity analysis, the ORs for hyperlipidemia across the quartiles of blood Pb levels were 1.00, 1.17 (95%CI: 1.05–1.30), 1.42 (95%CI: 1.24–1.62), and 1.38 (95%CI: 1.19–1.60) for Q1, Q2, Q3, and Q4, respectively ( P for trend & lt;0.001) after removing adults with arteriosclerotic cardiovascular disease, and the ORs were 1.00, 1.13 (95%CI: 1.01–1.25), 1.38 (95%CI: 1.21–1.56), and 1.32 (95%CI: 1.16–1.52) for Q1, Q2, Q3, and Q4, respectively ( P for trend & lt;0.001) after including pregnant women. Conclusion The current study showed a positive association between blood lead levels and hyperlipidemia.
    Type of Medium: Online Resource
    ISSN: 2296-2565
    URL: Article
    DOI: 10.3389/fpubh.2022.981749
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2022
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  • 6
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    Table2.XLSX
    Frontiers Media SA ; 2022
    In:  Frontiers in Pharmacology Vol. 13 ( 2022-12-16)
    Details
    In: Frontiers in Pharmacology, Frontiers Media SA, Vol. 13 ( 2022-12-16)
    Abstract: Adenosine A 2A receptors (A 2A Rs) appear early in the retina during postnatal development, but the roles of the A 2A Rs in the morphogenesis of distinct types of retinal ganglion cells (RGCs) during postnatal development and neonatal inflammatory response remain undetermined. As the RGCs are rather heterogeneous in morphology and functions in the retina, here we resorted to the Thy1-YFPH transgenic mice and three-dimensional (3D) neuron reconstruction to investigate how A 2A Rs regulate the morphogenesis of three morphologically distinct types of RGCs (namely Type I, II, III) during postnatal development and neonatal inflammation. We found that the A 2A R antagonist KW6002 did not change the proportion of the three RGC types during retinal development, but exerted a bidirectional effect on dendritic complexity of Type I and III RGCs and cell type-specifically altered their morphologies with decreased dendrite density of Type I, decreased the dendritic field area of Type II and III, increased dendrite density of Type III RGCs. Moreover, under neonatal inflammation condition, KW6002 specifically increased the proportion of Type I RGCs with enhanced the dendrite surface area and volume and the proportion of Type II RGCs with enlarged the soma area and perimeter. Thus, A 2A Rs exert distinct control of RGC morphologies to cell type-specifically fine-tune the RGC dendrites during normal development but to mainly suppress RGC soma and dendrite volume under neonatal inflammation.
    Type of Medium: Online Resource
    ISSN: 1663-9812
    URL: Article
    URL: Article
    URL: Article
    URL: Article
    URL: Article
    DOI: 10.3389/fphar.2022.1082997
    DOI: 10.3389/fphar.2022.1082997.s001
    DOI: 10.3389/fphar.2022.1082997.s002
    DOI: 10.3389/fphar.2022.1082997.s003
    DOI: 10.3389/fphar.2022.1082997.s004
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2022
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    SSG: 15,3
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  • 7
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    Effectiveness of gonadotrophin-releasing hormone agonist therapy to improve the outcomes of intrauterine insemination in patients suffering from stage I-II endometriosis
    Informa UK Limited ; 2022
    In:  Annals of Medicine Vol. 54, No. 1 ( 2022-12-31), p. 1330-1338
    Details
    In: Annals of Medicine, Informa UK Limited, Vol. 54, No. 1 ( 2022-12-31), p. 1330-1338
    Type of Medium: Online Resource
    ISSN: 0785-3890 , 1365-2060
    URL: Article
    DOI: 10.1080/07853890.2022.2071458
    Language: English
    Publisher: Informa UK Limited
    Publication Date: 2022
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  • 8
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    Venetoclax plus azacitidine and donor lymphocyte infusion in treating acute myeloid leukemia patients who relapse after allogeneic hematopoietic stem cell transplantation
    Springer Science and Business Media LLC ; 2022
    In:  Annals of Hematology Vol. 101, No. 1 ( 2022-01), p. 119-130
    Details
    In: Annals of Hematology, Springer Science and Business Media LLC, Vol. 101, No. 1 ( 2022-01), p. 119-130
    Abstract: This study aimed to evaluate the efficacy and safety of venetoclax plus azacitidine and donor lymphocyte infusion (DLI) in treating patients with relapsed acute myeloid leukemia (AML) after allogeneic hematopoietic stem cell transplantation (allo-HSCT). Twenty-six AML patients who relapsed after allo-HSCT were enrolled and treated with venetoclax plus azacitidine and DLI. Complete remission with incomplete recovery (CRi), partial remission (PR), and objective remission rate (ORR) were assessed, and then event-free survival (EFS) and overall survival (OS) were evaluated. Besides, adverse events were documented. Additionally, whole exome sequencing was performed in bone marrow samples. The CRi, PR, and ORR rates were 26.9%, 34.6%, and 61.5%, respectively. The median time of EFS and OS was 120 (95% CI: 71–610) days and 284.5 (95% CI: 81–610) days, respectively. The most common adverse events were hematologic system adverse events including agranulocytosis, anemia, and thrombocytopenia, while the adverse events of other systems were relatively less and milder. In addition, no serious adverse events existed. Of note, there were 6 (23.1%) patients who developed GVHD. As for gene mutation, 49 mutated genes were found, which were categorized as first-, second-, and third-class mutations, and then further analysis revealed that the first-class mutations were not correlated with EFS or OS. Additionally, the most frequent mutated genes were FLT3, CEBPA, DNMT3A, KIT, KRAS, and NRAS. Venetoclax plus azacitidine and DLI is efficient and tolerant in treating patients with relapsed AML after allo-HSCT, implying this combined therapy as a potential treatment option in the studied patients.
    Type of Medium: Online Resource
    ISSN: 0939-5555 , 1432-0584
    URL: Article
    DOI: 10.1007/s00277-021-04674-x
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2022
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  • 9
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    Data_Sheet_1.docx
    Frontiers Media SA ; 2022
    In:  Frontiers in Cardiovascular Medicine Vol. 9 ( 2022-6-24)
    Details
    In: Frontiers in Cardiovascular Medicine, Frontiers Media SA, Vol. 9 ( 2022-6-24)
    Abstract: To investigate associations between visceral adiposity index (VAI) and cardiovascular and cerebrovascular diseases (CCDs) in the American population from 1999 to 2018. Methods Data from the National Health and Nutrition Examination Survey (1998–2018) were analyzed in this study. Specifically, VAI scores were calculated using sex-specific equations that incorporate body mass index, waist circumference (WC), high-density lipoprotein (HDL), triglycerides (TG), and cholesterol. Weighted logistic regression analysis was conducted to assess the relationship between VAI tertile and increased risk of CCDs. Restricted cubic splines were used to evaluate the non-linear relationship between VAI and CCDs, such as heart failure, angina, heart attack, stroke, hypertension, and coronary heart disease. Sensitivity analysis was conducted, using VAI quartiles as independent variables. Results A total of 22,622 subjects aged over 20 years were included. In the fully adjusted model after controlling for covariates, the third VAI tertile was more strongly associated with CCDs than the first VAI tertile, with odds ratio (OR) and 95% confidence interval (95% CI) values for angina of 2.86, 1.68–4.85; heart attack, 1.75, 1.14–2.69; stroke, 2.01, 1.23–3.26; hypertension, 2.28, 1.86–2.78; and coronary heart disease, 1.78, 1.32–2.41; but there was no significant association with heart failure ( p & gt; 0.05). Restricted cubic splines revealed parabolic relationships between VAI score and angina ( p for non-linear = 0.03), coronary heart disease ( p for non-linear = 0.01), and hypertension ( p for non-linear & lt; 0.001). Sensitivity analysis indicated that the fourth VAI quartile was more strongly associated with an increased risk of angina (OR = 2.92, 95% CI, 1.49–5.69), hypertension (OR = 2.37, 95% CI, 1.90–2.97), heart attack (OR = 1.77, 95% CI, 1.09–2.88), and coronary heart disease (OR = 1.89, 95% CI, 1.24–2.86) than the first VAI quartile. VAI had superior predictive power for prevalent CCDs than other independent indicators ( p & lt; 0.05). Conclusion Visceral adiposity index score is positively correlated with angina, heart attack, stroke, hypertension, and coronary heart disease, but not heart failure, and the relationships between VAI score and angina, hypertension, and coronary heart disease are non-linear.
    Type of Medium: Online Resource
    ISSN: 2297-055X
    URL: Article
    URL: Article
    DOI: 10.3389/fcvm.2022.908020
    DOI: 10.3389/fcvm.2022.908020.s001
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2022
    detail.hit.zdb_id: 2781496-8
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  • 10
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    Evaluation of gadolinium deposition in cortical bone using three‐dimensional ultrashort echo time quantitative susceptibility mapping: A preliminary study
    Wiley ; 2023
    In:  NMR in Biomedicine
    Details
    In: NMR in Biomedicine, Wiley
    Abstract: The aim of the current study was to investigate the feasibility of three‐dimensional ultrashort echo time quantitative susceptibility mapping (3D UTE‐QSM) for the assessment of gadolinium (Gd) deposition in cortical bone. To this end, 40 tibial bovine cortical bone specimens were divided into five groups then soaked in phosphate‐buffered saline (PBS) solutions with five different Gd concentrations of 0, 0.4, 0.8, 1.2, and 1.6 mmol/L for 48 h. Additionally, eight rabbits were randomly allocated into three groups, consisting of a normal‐dose macrocyclic gadolinium‐based contrast agent (GBCA) group ( n  = 3), a high‐dose macrocyclic GBCA group ( n  = 3), and a control group ( n  = 2). All bovine and rabbit tibial bone samples underwent magnetic resonance imaging (MRI) on a 3‐T clinical MR system. A 3D UTE‐Cones sequence was utilized to acquire images with five different echo times (i.e., 0.032, 0.2, 0.4, 0.8, and 1.2 ms). The UTE images were subsequently processed with the morphology‐enabled dipole inversion algorithm to yield a susceptibility map. The average susceptibility was calculated in three regions of interest in the middle of each specimen, and the Pearson's correlation between the estimated susceptibility and Gd concentration was calculated. The bone samples soaked in PBS with higher Gd concentrations exhibited elevated susceptibility values. A mean susceptibility value of −2.47 ± 0.23 ppm was observed for bovine bone soaked in regular PBS, while the mean QSM value increased to −1.75 ± 0.24 ppm for bone soaked in PBS with the highest Gd concentration of 1.6 mmol/L. A strong positive correlation was observed between Gd concentrations and QSM values. The mean susceptibility values of rabbit tibial specimens in the control group, normal‐dose GBCA group, and high‐dose GBCA group were −4.11 ± 1.52, −3.85 ± 1.33, and −3.39 ± 1.35 ppm, respectively. In conclusion, a significant linear correlation between Gd in cortical bone and QSM values was observed. The preliminary results suggest that 3D UTE‐QSM may provide sensitive noninvasive assessment of Gd deposition in cortical bone.
    Type of Medium: Online Resource
    ISSN: 0952-3480 , 1099-1492
    URL: Article
    DOI: 10.1002/nbm.5035
    Language: English
    Publisher: Wiley
    Publication Date: 2023
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