In:
Frontiers in Pharmacology, Frontiers Media SA, Vol. 14 ( 2023-5-18)
Abstract:
Trans-δ-viniferin (TVN), as a natural extract, is a resveratrol dimer with attractive biological activities, particularly its anti-tumor character. However, the mechanism of TVN interfering with cancerous proliferation has not been fully understood. Herein in this study, we found that TVN could trigger cancerous mitochondrial membrane potential (ΔΨm) reduction, with intracellular reactive oxidative species (ROS) level increasing, leading to apoptosis, which makes TVN a promising candidate for lung cancer cells A549 treatment. Therefore, this study provides TVN as an option to meet the demand for higher antitumor availability with lower biotoxicity and other clinical applications.
Type of Medium:
Online Resource
ISSN:
1663-9812
DOI:
10.3389/fphar.2023.1190127
DOI:
10.3389/fphar.2023.1190127.s001
DOI:
10.3389/fphar.2023.1190127.s002
DOI:
10.3389/fphar.2023.1190127.s003
DOI:
10.3389/fphar.2023.1190127.s004
DOI:
10.3389/fphar.2023.1190127.s005
DOI:
10.3389/fphar.2023.1190127.s006
DOI:
10.3389/fphar.2023.1190127.s007
DOI:
10.3389/fphar.2023.1190127.s008
DOI:
10.3389/fphar.2023.1190127.s009
DOI:
10.3389/fphar.2023.1190127.s010
DOI:
10.3389/fphar.2023.1190127.s011
DOI:
10.3389/fphar.2023.1190127.s012
DOI:
10.3389/fphar.2023.1190127.s013
DOI:
10.3389/fphar.2023.1190127.s014
DOI:
10.3389/fphar.2023.1190127.s015
DOI:
10.3389/fphar.2023.1190127.s016
Language:
Unknown
Publisher:
Frontiers Media SA
Publication Date:
2023
detail.hit.zdb_id:
2587355-6
SSG:
15,3
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