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  • 1
    Online Resource
    Online Resource
    Informa UK Limited ; 2018
    In:  Xenobiotica Vol. 48, No. 1 ( 2018-01-02), p. 28-36
    In: Xenobiotica, Informa UK Limited, Vol. 48, No. 1 ( 2018-01-02), p. 28-36
    Type of Medium: Online Resource
    ISSN: 0049-8254 , 1366-5928
    Language: English
    Publisher: Informa UK Limited
    Publication Date: 2018
    detail.hit.zdb_id: 1485113-1
    SSG: 12
    SSG: 15,3
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  • 2
    Online Resource
    Online Resource
    Wiley ; 2021
    In:  Food Science & Nutrition Vol. 9, No. 10 ( 2021-10), p. 5428-5434
    In: Food Science & Nutrition, Wiley, Vol. 9, No. 10 ( 2021-10), p. 5428-5434
    Abstract: Due to their potential beneficial effects, anthocyanins and proanthocyanins have attracted great concern worldwide. Recently, anthocyanin/proanthocyanin‐related health products have occupied a certain proportion of the market. However, there has not been a systematical assessment on collecting and analyzing the relevant information. In this study, information of anthocyanin/proanthocyanin‐related health products on sale on the four major online shopping platforms in China has been collected from November 2020 to February 2021. A total of 144 valid samples from 91 brands were collected, among which blueberries and grape seeds are the main sources of anthocyanins and proanthocyanins, respectively. Besides, the average anthocyanins/proanthocyanins content in these products is 22.71%. Improving eyesight, anti‐asthenopia and anti‐oxidation are widely mentioned among the anthocyanin‐related products, while more proanthocyanin‐related products declare for anti‐oxidation, whitening & spot lighting, and delay of skin aging & repairing skin damage effects. Among the products, 77.78% are capsules and tablets, and the average unit price of anthocyanins/proanthocyanins is $ 5.26/g. Data analysis shows that searching for high‐quality raw materials, researching on the varieties and content of anthocyanins/proanthocyanins, focusing on the intake of specific population, and exploring better storage forms of anthocyanins/proanthocyanins may be important field in the future to promote the development of the anthocyanin/proanthocyanin‐related health products.
    Type of Medium: Online Resource
    ISSN: 2048-7177 , 2048-7177
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 2703010-6
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  • 3
    In: Frontiers in Nutrition, Frontiers Media SA, Vol. 8 ( 2021-5-19)
    Abstract: Celiac disease (CD) is a prevalent disorder with autoimmune features. Dietary exposure of wheat gluten (including gliadins and glutenins) to the small intestine activates the gluten-reactive CD4 + T cells and controls the disease development. While the human leukocyte antigen (HLA) is the single most important genetic factor of this polygenic disorder, HLA-DQ2 recognition of gluten is the major biological step among patients with CD. Gluten epitopes are often rich in Pro and share similar primary sequences. Here, we simulated the solution structures changes of a variety of gluten epitopes under different pH and temperatures, to mimic the fermentation and baking/cooking processes. Based on the crystal structure of HLA-DQ2, binding of differently processed gluten epitopes to DQ2 was studied in silico . This study revealed that heating and pH change during the fermentation process impact the solution structure of gluten epitope. However, binding of differently treated gluten epitope peptide (GEP) to HLA-DQ2 mainly depended on its primary amino acid sequence, especially acidic amino acid residues that play a pivotal role in their recognition by HLA-DQ2.
    Type of Medium: Online Resource
    ISSN: 2296-861X
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2021
    detail.hit.zdb_id: 2776676-7
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  • 4
    Online Resource
    Online Resource
    Springer Science and Business Media LLC ; 2016
    In:  European Journal of Drug Metabolism and Pharmacokinetics Vol. 41, No. 4 ( 2016-8), p. 441-448
    In: European Journal of Drug Metabolism and Pharmacokinetics, Springer Science and Business Media LLC, Vol. 41, No. 4 ( 2016-8), p. 441-448
    Type of Medium: Online Resource
    ISSN: 0378-7966 , 2107-0180
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2016
    detail.hit.zdb_id: 2558337-2
    SSG: 15,3
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  • 5
    Online Resource
    Online Resource
    MDPI AG ; 2021
    In:  Nutrients Vol. 13, No. 10 ( 2021-09-27), p. 3397-
    In: Nutrients, MDPI AG, Vol. 13, No. 10 ( 2021-09-27), p. 3397-
    Abstract: Crustacean allergy, especially to shrimp, is the most predominant cause of seafood allergy. However, due to the high flexibility of immunoglobulin E (IgE), its three-dimensional structure remains unsolved, and the molecular mechanism of shrimp allergen recognition is unknown. Here a chimeric IgE was built in silico, and its variable region in the light chain was replaced with sequences derived from shrimp tropomyosin (TM)-allergic patients. A variety of allergenic peptides from the Chinese shrimp TM were built, treated with heating, and subjected to IgE binding in silico. Amino acid analysis shows that the amino acid residue conservation in shrimp TM contributes to eliciting an IgE-mediated immune response. In the shrimp-allergic IgE, Glu98 in the light chain and other critical residues that recognize allergens from shrimp are implicated in the molecular basis of IgE-mediated shrimp allergy. Heat treatment could alter the conformations of TM allergenic peptides, impact their intramolecular hydrogen bonding, and subsequently decrease the binding between these peptides and IgE. We found Glu98 as the characteristic amino acid residue in the light chain of IgE to recognize general shrimp-allergic sequences, and heat-induced conformational change generally desensitizes shrimp allergens.
    Type of Medium: Online Resource
    ISSN: 2072-6643
    Language: English
    Publisher: MDPI AG
    Publication Date: 2021
    detail.hit.zdb_id: 2518386-2
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