In:
Oncology Research and Treatment, S. Karger AG, Vol. 41, No. 1-2 ( 2018), p. 14-21
Abstract:
〈 b 〉 〈 i 〉 Objective: 〈 /i 〉 〈 /b 〉 We performed a meta-analysis to estimate the association between 〈 i 〉 IL-13 〈 /i 〉 gene rs20541 (R130Q) polymorphism and the susceptibility of glioma. 〈 b 〉 〈 i 〉 Patients and Methods: 〈 /i 〉 〈 /b 〉 Potentially eligible studies published before February 1, 2016 were searched in 4 databases including PubMed, EMBASE, EBSCO, and Ovid. Odds ratios (ORs) and their corresponding 95% confidence intervals (95% CIs) were used to estimate the strength of relationship between the 〈 i 〉 IL-13 〈 /i 〉 gene rs20541 polymorphism and glioma susceptibility. Stata 11.0 software was used to perform the present meta-analysis. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 In total, 10 case-control studies with 13 datasets including 3,123 cases and 5,390 controls were identified. A significant increase in glioma susceptibility was found in the dominant model (AA + AG vs. GG: OR = 1.14, 95% CI 1.01-1.29; P = 0.031). Significantly decreasing glioma susceptibility was found for Asians in the heterozygote comparison (AG vs. GG: OR = 0.74, 95% CI 0.55-0.99; P = 0.042) and the allele contrast genetic model (A vs. G: OR = 0.67, 95% CI 0.47-0.96; P = 0.028). By contrast, in Caucasians, a significant increase in glioma susceptibility was found in the dominant model (AA + AG vs. GG: OR = 1.25, 95% CI 1.11-1.41; P = 0.000). 〈 b 〉 〈 i 〉 Conclusion: 〈 /i 〉 〈 /b 〉 There may be a weak association between the 〈 i 〉 IL-13 〈 /i 〉 gene rs20541 polymorphism and glioma susceptibility, and the associations may be different between ethnicities.
Type of Medium:
Online Resource
ISSN:
2296-5270
,
2296-5262
Language:
English
Publisher:
S. Karger AG
Publication Date:
2018
detail.hit.zdb_id:
2749752-5
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