In:
Advanced Healthcare Materials, Wiley, Vol. 7, No. 24 ( 2018-12)
Abstract:
Compared with other subtypes of breast cancer, triple‐negative breast cancer (TNBC) is seriously threatening to human life. Therefore, it is a matter of urgency to develop multifunctional nanoprobes for visualized theranostics of TNBC, achieving specific targeting toward only TNBC, but not other subtypes. Nanoscale metal–organic frameworks (MOFs) show important potential in visualized theranostics of tumors, but it is critical to synthesize well‐defined core–shell MOF‐based nanocomposites by encapsulating a single nanoparticle within MOF. In this study, a TNBC‐targeted peptide (ZD2)‐engineered, and a single gold nanostar (AuNS) coated within MIL‐101‐NH 2 (Fe) by coating MOF with four cycles, obtain well‐defined core–shell AuNS@MOF‐ZD2 nanocomposites, which are expected to achieve T 1 ‐weighted magnetic resonance imaging and photothermal therapy (PTT) specifically targeting toward TNBC. The prepared AuNS@MOF‐ZD2 nanocomposites possess good biocompatibility, efficient T 1 ‐weighted magnetic resonance (MR) relaxivity and stable photothermal conversion ability with an efficiency of 40.5%. The in vitro and in vivo characterizations prove their performances of T 1 ‐weighted MR and PTT with a low power density of 808 nm laser, achieving excellent theranostic efficacy in TNBC. Importantly, it is demonstrated that the prepared AuNS@MOF‐ZD2 nanoprobes can specifically target TNBC cells (MDA‐MB‐231), but not other subtypes of breast cancer cells (MDA‐MB‐435, MDA‐MB‐468, and MCF‐7), indicating their promising application in visualized theranostics of breast cancers with molecular classification.
Type of Medium:
Online Resource
ISSN:
2192-2640
,
2192-2659
DOI:
10.1002/adhm.201801144
Language:
English
Publisher:
Wiley
Publication Date:
2018
detail.hit.zdb_id:
2645585-7
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