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  • 1
    In: Geofluids, Hindawi Limited, Vol. 2021 ( 2021-2-2), p. 1-11
    Abstract: During the long-term waterflooding (LTWF) in oil reservoirs, the formation is subject to permeability reduction as clay release and fine migration. At present, the mechanisms of permeability impairment in both macroscopic and microscopic pore structures in ultralow permeability reservoirs under LTWF are unclear. This statement epitomizes the main objective of this work: to understand how long-term waterflood changes porous structures and thus compromises permeability. The standard core flow experiments in conjunction with a couple of tests consisting of online nuclear magnetic resonance (NMR), high-pressure mercury intrusive penetration (HPMIP), X-ray diffraction (XRD), and scanning electron microscope (SEM) were performed to determine the mineral compositions, macrophysical properties, and micropore structures of two kinds of cores with different natures of pore distribution (i.e., unimodal and bimodal) before and after LTWF in Yan Chang field China. Results showed that the permeability decreased while the porosity increased after the LTWF. With respect to the pore size distribution, the small pores (SPs) decreased and the large pores (LPs) increased for both cores. For the unimodal core, the distribution curve shifted upwards with little change in the radius of the connected pores. For the bimodal core, the curve shifted to the right with an increasing radius of connected pores. With respect to the characteristic parameters, the average pore radius, median pore radius, structural coefficient, and tortuosity increased, while the relative sorting coefficient decreased. The relative changes of the parameters for the unimodal core were much smaller than those for the bimodal core. With respect to the clays, chlorite accounted for a majority proportion of the clays, and its content increased after LTWF. According to these changes, the mechanism of LTWF at different stages was interpreted. At the early stages, the blockage of the released clays occurred in SPs. Some of the middle pores (MPs) and LPs became larger due to the release and some of them became smaller due to the accumulation. At the middle stage, the blockage of SPs weakened. Some flow channels formed by MPs and LPs became dominant flow channels gradually. The effluxes of particles occurred, resulting in a significant increase in porosity. At the late stage, the stable flow channels have formed. The higher response of the bimodal core to LTWF could be attributed to its higher content of chlorite, which was more likely to accumulate. This study clarifies the mechanism of fine-migration-induced formation damage in microscopic pore structures and the migration pattern of clay minerals in ultralow permeability reservoirs. The work provides potential guidance for optimizing waterflood strategies in ultralow permeability reservoirs.
    Type of Medium: Online Resource
    ISSN: 1468-8123 , 1468-8115
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2021
    detail.hit.zdb_id: 2045012-6
    SSG: 13
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  • 2
    Online Resource
    Online Resource
    Royal Society of Chemistry (RSC) ; 2018
    In:  Catalysis Science & Technology Vol. 8, No. 24 ( 2018), p. 6503-6510
    In: Catalysis Science & Technology, Royal Society of Chemistry (RSC), Vol. 8, No. 24 ( 2018), p. 6503-6510
    Type of Medium: Online Resource
    ISSN: 2044-4753 , 2044-4761
    Language: English
    Publisher: Royal Society of Chemistry (RSC)
    Publication Date: 2018
    detail.hit.zdb_id: 2595090-3
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  • 3
    Online Resource
    Online Resource
    Elsevier BV ; 2022
    In:  SSRN Electronic Journal
    In: SSRN Electronic Journal, Elsevier BV
    Type of Medium: Online Resource
    ISSN: 1556-5068
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2022
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  • 4
    Online Resource
    Online Resource
    American Chemical Society (ACS) ; 2018
    In:  Energy & Fuels Vol. 32, No. 5 ( 2018-05-17), p. 5789-5798
    In: Energy & Fuels, American Chemical Society (ACS), Vol. 32, No. 5 ( 2018-05-17), p. 5789-5798
    Type of Medium: Online Resource
    ISSN: 0887-0624 , 1520-5029
    Language: English
    Publisher: American Chemical Society (ACS)
    Publication Date: 2018
    detail.hit.zdb_id: 1483539-3
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  • 5
    In: Medical Oncology, Springer Science and Business Media LLC, Vol. 38, No. 10 ( 2021-10)
    Abstract: Although patients with early localized prostate cancer can survive longer, castration-resistant prostate cancer (CRPC) has gradually emerged with the use of androgen deprivation therapy (ADT). N-Myc and TEM8 play a vital role in the progression of several cancer types. However, the underlying mechanism of how N-Myc and TEM8 promote the progression of prostate cancer remains unclear. In this study, the expression of N-Myc and TEM8 was detected in benign prostatic hyperplasia (BPH) and prostate cancer (PCa) tissues by immunohistochemistry (IHC). LNCaP cell lines were maintained in RPMI 1640 medium supplemented with 10% charcoal-stripped fetal bovine serum. Subsequently, R language software was used to verify our results. Tubule formation assay of human umbilical vein endothelial cell (HUVEC) was conducted to examine the effect of N-Myc and TEM8 overexpression on angiogenesis in prostate cancer cells. IHC results showed a positive correlation between the expression of N-Myc and TEM8 in prostate cancer tissues. Further analysis showed that N-Myc and TEM8 were associated with clinicopathological features and poor prognosis in prostate cancer patients. Moreover, the overexpression of N-Myc and TEM8 promoted proliferation of prostate cancer cells and angiogenesis. Additionally, N-Myc and TEM8 overexpression was associated with therapeutic resistance. We further found that N -Myc promoted angiogenesis and therapeutic resistance in prostate cancer via TEM8 . Hence, targeting N-Myc / TEM8 pathway in prostate cancer would be a novel therapeutic strategy to enhance the treatment of prostate cancer patients.
    Type of Medium: Online Resource
    ISSN: 1357-0560 , 1559-131X
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2021
    detail.hit.zdb_id: 1201189-7
    detail.hit.zdb_id: 605563-1
    detail.hit.zdb_id: 2008172-8
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  • 6
    In: Chemical Engineering Journal, Elsevier BV, Vol. 395 ( 2020-09), p. 125053-
    Type of Medium: Online Resource
    ISSN: 1385-8947
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2020
    detail.hit.zdb_id: 241367-X
    detail.hit.zdb_id: 2012137-4
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  • 7
    In: Combustion Science and Technology, Informa UK Limited
    Type of Medium: Online Resource
    ISSN: 0010-2202 , 1563-521X
    Language: English
    Publisher: Informa UK Limited
    Publication Date: 2022
    detail.hit.zdb_id: 2027674-6
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  • 8
    In: Geofluids, Hindawi Limited, Vol. 2021 ( 2021-2-9), p. 1-12
    Abstract: The key rock mechanical parameters are strength, elastic modulus, Poisson’s ratio, etc., which are important in reservoir development. The accurate determination of reservoir’s mechanical properties is critical to reduce drilling risk and maximize well productivity. Precisely estimating rock mechanical properties is important in drilling and well completion design, as well as crucial for hydraulic fracturing. Rocks are heterogeneous and anisotropic materials. The mechanical properties vary not only with rock types but also with measurement methods, sample geometric dimensions (sample length to diameter ratio and size), and other factors. To investigate sample scale effects on rock mechanical behaviors, unconfined compression tests were conducted on 41 different geometric dimensions of Berea sandstones; unconfined compressive strength (UCS), Young’s modulus ( E ), Poisson’s ratio ( υ ), bulk modulus ( K ), and shear modulus ( G ) were obtained and compared. The results indicate that sample geometry can significantly affect rock mechanical properties: (1) UCS decreases with the increase of length to diameter ratio (LDR), and the UCS standardize factor is between 0.71 and 1.17, which means -30% to +20% variation of UCS with LDR changing from 1 to 6.7. The test results show UCS exhibits positive relationship with sample size. (2) Young’s modulus slightly increases with LDR increases, while Poisson’s ratio decreases with the increase of LDR. For the tested Berea sandstones, Poisson’s ratio standardizing factor is between 0.57 and 1.11. (3) Bulk modulus of Berea sandstone samples decreases with the increase of LDR, while shear modulus increases with LDR increases. Both bulk modulus and shear modulus increase with the increase of sample size. (4) The principal failure modes were analyzed. The failure modes of the tested Berea sandstones are axial splitting and shear failure. Stocky samples ( LDR 〈 2 ) tend to go axial splitting, while slender samples ( LDR 〉 2 ) tend to show shear failure.
    Type of Medium: Online Resource
    ISSN: 1468-8123 , 1468-8115
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2021
    detail.hit.zdb_id: 2045012-6
    SSG: 13
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  • 9
    In: Geofluids, Hindawi Limited, Vol. 2021 ( 2021-4-16), p. 1-11
    Abstract: To address the issues of reservoir blockage and sharp decline in fluid output of production wells in the polymer injection zone of the Henan oilfield, physical modeling has been used to study the blockage mechanism and blockage locations of the polymer-flooded reservoir based on oil reservoir characteristics and blockage knowledge. The results show that all the constant pressures in the low, moderate, and high permeability cores subjected to polymer injection and subsequent waterflooding were higher than the constant pressure during primary waterflooding; hence, polymer retention and blockage phenomena were obvious in the cores; in the high permeability core, the pore surface adsorbed more polymer molecules though pore throat radii were still much greater than the size of the polymer molecule, suggesting that polymer blockage is mainly caused by adsorption and retention. For the low permeability core, the specific surface area of the inlet end was much larger than that in the high permeability core, leading to more serious capture of polymer molecules at the small pores, indicating that blockage under polymer injection is mainly caused by capture and retention; for the lower permeability (91.81 mD) core, as compared with the case prior to polymer injection, the polymer-injected core had fewer large pores and throats, the mean pore throat radius decreased from 42.2 μm to 39.9 μm, and the mean throat-to-pore coordination number decreased from 3.36 to 3.19; thus, polymer capture and retention led to core blockage; the leftward shift of the curve corresponding to the porosity component, high porosity peak weakening after polymer injection, moderate and low porosity peaks appearing after polymer injection, and enhancement of lower porosity peaks indicate that, after polymer injection and subsequent waterflooding, polymer adsorption and capture led to blockage of some large pores; the highest pressure gradient, i.e., 6.3 MPa/m, was achieved at the P2-P3 segment; thus, the worst blockage occurred at the P2-P3 stage, or 1/8-1/4 of the sandpack length. In this paper, Nanbaxian oil and gas field, China, was taken as an example to investigate the interpretation method of gas saturation in a complex pore structure. The “four properties” relationship of the formation reservoir in the Nanbaxian oil and gas field was studied in depth according to the conventional logging data and core analysis data. The neural network algorithm was used to reconstruct the resistivity curve of the water layer to eliminate the influence of lithology, shale content, and pore structure on the resistivity. The difference between the reconstructed curve and the measured resistivity curve was used to identify the gas and water, and the ratio of the two was used to calculate the gas saturation, and good results were achieved. It was found that the sedimentary types of the Nanbaxian oil and gas field cause the reservoir to be thin, numerous, and dispersed; the lateral correlation is difficult. In addition, the structural features lead to the reservoir types being various in the vertical direction, which makes the identification of reservoir fluid more difficult. The results revealed that the rock compaction, poor physical properties, complex pore structure, high resistivity of surrounding rocks, and low formation water salinity make the water layer with high resistivity and difficult to identify gas and water.
    Type of Medium: Online Resource
    ISSN: 1468-8123 , 1468-8115
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2021
    detail.hit.zdb_id: 2045012-6
    SSG: 13
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  • 10
    Online Resource
    Online Resource
    Elsevier BV ; 2018
    In:  Journal of Natural Gas Science and Engineering Vol. 57 ( 2018-09), p. 178-188
    In: Journal of Natural Gas Science and Engineering, Elsevier BV, Vol. 57 ( 2018-09), p. 178-188
    Type of Medium: Online Resource
    ISSN: 1875-5100
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2018
    detail.hit.zdb_id: 2514802-3
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