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  • 1
    Online Resource
    Online Resource
    Parallel Interrogation of β-Arrestin2 Recruitment for Ligand Screening on a GPCR-Wide Scale using PRESTO-Tango Assay
    MyJove Corporation ; 2020
    In:  Journal of Visualized Experiments , No. 157 ( 2020-03-10)
    Details
    In: Journal of Visualized Experiments, MyJove Corporation, , No. 157 ( 2020-03-10)
    Type of Medium: Online Resource
    ISSN: 1940-087X
    URL: Article
    DOI: 10.3791/60823
    Language: English
    Publisher: MyJove Corporation
    Publication Date: 2020
    detail.hit.zdb_id: 2259946-0
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  • 2
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    Online Resource
    Effects of vanillin on potassium bromate-induced neurotoxicity in adult mice: impact on behavior, oxidative stress, genes expression, inflammation and fatty acid composition
    Informa UK Limited ; 2017
    In:  Archives of Physiology and Biochemistry Vol. 123, No. 3 ( 2017-05-27), p. 165-174
    Details
    In: Archives of Physiology and Biochemistry, Informa UK Limited, Vol. 123, No. 3 ( 2017-05-27), p. 165-174
    Type of Medium: Online Resource
    ISSN: 1381-3455 , 1744-4160
    URL: Article
    DOI: 10.1080/13813455.2017.1283527
    Language: English
    Publisher: Informa UK Limited
    Publication Date: 2017
    detail.hit.zdb_id: 2002503-8
    SSG: 12
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  • 3
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    Acute phase of epidemic keratoconjunctivitis: Management in practice
    Wiley ; 2022
    In:  Acta Ophthalmologica Vol. 100, No. S275 ( 2022-12)
    Details
    In: Acta Ophthalmologica, Wiley, Vol. 100, No. S275 ( 2022-12)
    Abstract: Purpose: To describe current trends in therapeutic modalities to manage acute epidemic keratoconjunctivitis. Methods: We ran a descriptive study of 87 eyes of 61 patients diagnosed with acute epidemic keratoconjunctivitis confirmed by the presence of subepithelial infiltrates (SEIs) in the cornea. A clinical score based on a complete biomicroscopic examination, the measurement of visual acuity, the number of subepithelial infiltrates (SEIs), the break‐up‐time, and the value of the Schirmer type 1, has been established to evaluate symptoms. Results: The mean age of the study population was 36 ± 17 years‐old. The treatments taken in the acute phase were either prescribed by a general practitioner (10%) or an ophthalmologist (60%), or taken as self‐medication (30%). None of our patients has received nonsteroidal anti‐inflammatory eye drops. Antivirals including ganciclovir were taken by 40% of the study group, artificial tears in 81 eyes (93%), antiseptics in 21% of the cases, and local antibiotics in 46 eyes (53%). The mean clinical score was 4.2 ± 2.6. There was no significant difference in the final clinical score, visual acuity, number of SEIs, break‐up time and Schirmer's value between the groups who instilled ganciclovir, artificial tears, local antibiotics as well as the healing agents and those who did not. Visual acuity was better in patients who did not use antiseptic eye drops. Conclusions: The latest treatment recommended for the acute phase of epidemic keratoconjunctivitis are artificial tears with cold compresses, local povidone‐iodine and ganciclovir. Topical antibiotics are only used in confirmed bacterial superinfection. Our studied sample did not respond much to these recommendations.
    Type of Medium: Online Resource
    ISSN: 1755-375X , 1755-3768
    URL: Issue
    URL: Article
    DOI: 10.1111/aos.v100.s275
    DOI: 10.1111/j.1755-3768.2022.0668
    Language: English
    Publisher: Wiley
    Publication Date: 2022
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  • 4
    Online Resource
    Online Resource
    Parallel Interrogation of β-Arrestin2 Recruitment for Ligand Screening on a GPCR-Wide Scale using PRESTO-Tango Assay
    MyJove Corporation ; 2020
    In:  Journal of Visualized Experiments , No. 157 ( 2020-03-10)
    Details
    In: Journal of Visualized Experiments, MyJove Corporation, , No. 157 ( 2020-03-10)
    Type of Medium: Online Resource
    ISSN: 1940-087X
    URL: Article
    DOI: 10.3791/60823-v
    Language: English
    Publisher: MyJove Corporation
    Publication Date: 2020
    detail.hit.zdb_id: 2259946-0
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  • 5
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    Flavonoid compounds from the red marine alga Alsidium corallinum protect against potassium bromate‐induced nephrotoxicity in adult mice
    Wiley ; 2017
    In:  Environmental Toxicology Vol. 32, No. 5 ( 2017-05), p. 1475-1486
    Details
    In: Environmental Toxicology, Wiley, Vol. 32, No. 5 ( 2017-05), p. 1475-1486
    Abstract: Potassium bromate (KBrO 3 ), an environmental pollutant, is a well‐known human carcinogen and a potent nephrotoxic agent. Currently, natural products have built a well‐recognized role in the management of many diseases induced by pollutants. As potent natural sources of bioactive compounds, marine algae have been demonstrated to be rich in novel secondary metabolites with a broad range of biological functions. In this study, adults male mice were orally treated for 15 days with KBrO 3 (0.5 g/L) associated or not with extract of Alsidium corallinum , a red Mediterranean alga. In vitro study demonstrated that algal extract has antioxidant efficacy attributable to the presence of flavonoids and polyphenols. Among these, Liquid chromatography–mass spectrometry analysis showed A. corallinum is rich in kaempferol, apigenin, catechin, and quercetin flavonoids. In vivo study showed that supplementation with the alga significantly prevented KBrO 3 ‐induced nephrotoxicity as indicated by plasma biomarkers (urea, uric acid, and creatinin levels) and oxidative stress related parameters (malondialdehyde, superoxide dismutase, catalase, glutathione peroxidase, reduced glutathione, vitamin C, hydrogen peroxide, protein oxidation products) in kidney tissue. The corrective effect of A. corallinum on KBrO 3 ‐induced kidney injury was also supported by molecular and histopathological observations. In conclusion, it was established that the red alga, thanks to its bioactive compounds, effectively counteracts toxic effects of KBrO 3 and could be a useful coadjuvant agent for treatment of this pollutant poisonings. © 2016 Wiley Periodicals, Inc. Environ Toxicol 32: 1475–1486, 2017.
    Type of Medium: Online Resource
    ISSN: 1520-4081 , 1522-7278
    URL: Issue
    URL: Article
    DOI: 10.1002/tox.v32.5
    DOI: 10.1002/tox.22368
    Language: English
    Publisher: Wiley
    Publication Date: 2017
    detail.hit.zdb_id: 2027534-1
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  • 6
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    Online Resource
    Traumatic acute retrobulbar haemorrhage complicated with central retinal artery occlusion
    Wiley ; 2022
    In:  Acta Ophthalmologica Vol. 100, No. S275 ( 2022-12)
    Details
    In: Acta Ophthalmologica, Wiley, Vol. 100, No. S275 ( 2022-12)
    Abstract: Purpose: To present the vascular complications of traumatic acute retrobulbar haemorrhage and describe its management through a case report. Methods: A case report of a patient having an acute retrobulbar haemorrhage complicated with central retinal artery occlusion (CRAO). Results: A 50‐year‐old male patient exposed to blunt orbital trauma two hours prior was referred to the emergency with complaints of pain and loss of vision in the left eye. The negative light perception was noted in this eye. A tense hematoma, proptosis, ophthalmoplegia, and a non‐reactive pupil were also noted. Biomicroscopic examination, revealed corneal edema, subconjunctival haemorrhage, and chemosis. The fundus examination was not possible. Intraocular pressure (IOP) was 60 mmHg. The patient was diagnosed with acute retrobulbar haemorrhage. Computerized tomography was performed immediately showing a fracture of the left medial orbital wall and haemorrhage within the retrobulbar space. Intravenous mannitol and topical dorzolamide‐timolol associated with oral corticosteroid were administered. IOP decreased to 30 mmHg, but the patient's visual acuity did not improve. The fundus examination revealed a total CRAO confirmed by the fluorescein angiography and OCT‐A showing massive ischemic edema and occluded perimacular arterioles with interruption to the choroidal blood flow. OCT images demonstrated an increased reflectivity and thickness of the inner retina and subretinal fluid, which corresponds to the acute phase of CRAO. The time of surgical treatment was missed, and as a result, the patient missed their chance for visual recovery. Conclusions: Retrobulbar haemorrhage is a complication from ocular trauma that may cause permanent vision loss. Retrobulbar haemorrhage can potentially lead to dangerous increases in intraorbital pressure, a condition that is also described as orbital compartment syndrome. This increase in pressure is sufficient to cause vision loss, whether through direct compression of the optic nerve leading to optic neuropathy, a central retinal artery occlusion, or compression of the vessels that provide nutrition to the optic nerve.
    Type of Medium: Online Resource
    ISSN: 1755-375X , 1755-3768
    URL: Issue
    URL: Article
    DOI: 10.1111/aos.v100.s275
    DOI: 10.1111/j.1755-3768.2022.0688
    Language: English
    Publisher: Wiley
    Publication Date: 2022
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  • 7
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    Online Resource
    Multimodal imaging in persistent fetal vasculature
    Wiley ; 2022
    In:  Acta Ophthalmologica Vol. 100, No. S275 ( 2022-12)
    Details
    In: Acta Ophthalmologica, Wiley, Vol. 100, No. S275 ( 2022-12)
    Abstract: Purpose: To describe the clinical manifestations of the persistence of the fetal vascular system and to show multimodal imaging findings in this disease. Methods: We presented two cases of persistent fetal vasculature. Thorough clinical examination and full multimodal imaging have been undertaken. Results: The first case is a 12‐year‐old girl who consulted for a visual impairment evolving for few years. Fundoscopy revealed a unilateral whitish vascular membrane attached to the optic disc towards the vitreous associated with retinal folds in interpapillomacular region as well as chorio‐retinal atrophy and nasal pigment migrations. B‐mode ultrasonography confirmed the presence of this membrane attached to the optic disc but does not reach the lens. Optical coherence tomography (OCT) showed a deficit of RNFL, especially in superotemporal and hyaloid condensation in the optic disc with macular folds. The second case is a 42‐year‐old patient who consulted for a presbyopia. Fundoscopy revealed membranous short band‐like lesion attached to the optic disc associated with retinal folds, better seen in the anerythral photograph which showed an alternation of grey and white bands. Conclusions: Multimodal imaging is of a paramount importance in diagnosing the fetal vascular system. It also allows the recognition of the form of this disease and thus the way to manage it.
    Type of Medium: Online Resource
    ISSN: 1755-375X , 1755-3768
    URL: Issue
    URL: Article
    DOI: 10.1111/aos.v100.s275
    DOI: 10.1111/j.1755-3768.2022.0706
    Language: English
    Publisher: Wiley
    Publication Date: 2022
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  • 8
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    Online Resource
    Ocular manifestations in Arnold Chiari syndrome
    Wiley ; 2022
    In:  Acta Ophthalmologica Vol. 100, No. S275 ( 2022-12)
    Details
    In: Acta Ophthalmologica, Wiley, Vol. 100, No. S275 ( 2022-12)
    Abstract: Purpose: Arnold‐Chiari disease is a rare congenital malformation of the cerebellum. Symptoms are dominated by occipital headache, torticollis, and sometimes swallowing disorders. Regarding ophthalmological manifestations, convergence abnormalities, oculomotor paralysis and diplopia are the main clinical signs. We report two cases of ocular manifestations in Arnold Chiari type 1 syndrome. Methods: Two case reports and a literature review. Results: Case 1: A 40‐year‐old patient with no medical history presented an acute loss of vision in both eyes. On examination, the patient had a visual acuity limited to 5/63. Biomicroscopic examination of the anterior segment was without abnormalities. Fundus examination revealed a bilateral papillary edema. Visual field test showed a borderline diffuse loss in both eyes. Case 2: A 17‐year‐old patient with no medical history presented intermittent headaches and a progressive loss of vision in both eyes. On examination, the patient had a visual acuity limited to 5/80. Biomicroscopic examination of the anterior segment was without abnormalities. Fundus examination revealed atrophy not excavated in both eyes. Visual field test showed nasal and temporal scotomas in both eyes. Temporal, superior and inferior RNFL defects were detected in both eyes. A brain MRI revealed a Chiari type 1 malformation without associated hydrocephalus in both patients. Conclusions: Arnold Chiari type 1 malformation is an uncommon pathology. The discovery of ophthalmologic signs requires a neurosurgical intervention as soon as possible to stop progression towards the loss of visual function by optic atrophy.
    Type of Medium: Online Resource
    ISSN: 1755-375X , 1755-3768
    URL: Issue
    URL: Article
    DOI: 10.1111/aos.v100.s275
    DOI: 10.1111/j.1755-3768.2022.0681
    Language: English
    Publisher: Wiley
    Publication Date: 2022
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  • 9
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    Online Resource
    Analyse comparative des principaux mécanismes de gouvernance dans les multinationales américaines, européennes et asiatiques appartenant à la liste Fortune Global 250
    HEC Montréal ; 2020
    In:  Management international Vol. 24, No. 2 ( 2020-10-22), p. 27-38
    Details
    In: Management international, HEC Montréal, Vol. 24, No. 2 ( 2020-10-22), p. 27-38
    Abstract: El objetivo de esta investigación es comparar los mecanismos de gobernanza de las empresas multinacionales (EMN) que cotizan en los mercados bursátiles de las principales regiones geográficas, es decir los Estados Unidos, Europa y Asia, para determinar si estas EMN están convergiendo hacia la estandarización de sus prácticas de gobernanza. Nuestros resultados, basados en una muestra de 156 EMN pertenecientes a la lista Fortune Global 250 y utilizando una prueba ANOVA, mostraron que no hay convergencia hacia un modelo internacional y que la elección de prácticas de gobernanza para las EMN parece más bien estar asociada a criterios regionales.
    Type of Medium: Online Resource
    ISSN: 1918-9222 , 1206-1697
    URL: Article
    DOI: 10.7202/1072639ar
    Language: French
    Publisher: HEC Montréal
    Publication Date: 2020
    detail.hit.zdb_id: 2169059-5
    SSG: 3,2
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  • 10
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    Online Resource
    An analysis of the determinants of corporate governance disclosure policies in multinational enterprises: A multi- medium study
    Virtus Interpress ; 2015
    In:  Corporate Ownership and Control Vol. 12, No. 4 ( 2015), p. 671-694
    Details
    In: Corporate Ownership and Control, Virtus Interpress, Vol. 12, No. 4 ( 2015), p. 671-694
    Abstract: This research aims to identify the factors underlying the corporate governance disclosure policies of the world’s largest multinational companies (MNCs) based on the following: (1) national factors related to the MNCs’ home countries (2) governance factors related to their governance systems and (3) operational factors arising from the operational characteristics of the MNCs. Methodology – Our sample includes 159 MNCs from 24 countries representing three geographic regions. The corporate governance disclosure policy is examined in terms of level and quality of disclosed information in two different mediums (traditional i.e .paper vs. websites). Results – Multiple linear regressions indicate that national factors, especially cultural ones, are important determinants of MNCs corporate governance disclosure policy in the traditional print mediums. National factors, however, seem to play no part in governance disclosures on the internet but can rather be explained by the international MNCs listing status. Practical implications – This study could guide the harmonization efforts of international standard setters in identifying factors leading to different governance disclosure behaviors and the disclosure medium most influenced by these factors.
    Type of Medium: Online Resource
    ISSN: 1810-3057 , 1727-9232
    URL: Journal
    URL: Article
    DOI: 10.22495/coc
    DOI: 10.22495/cocv12i4c6p7
    Language: English
    Publisher: Virtus Interpress
    Publication Date: 2015
    detail.hit.zdb_id: 2155954-5
    SSG: 3,2
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