In:
Angewandte Chemie, Wiley, Vol. 128, No. 39 ( 2016-09-19), p. 12100-12103
Abstract:
A nickel‐catalyzed Heck cyclization for the construction of quaternary stereocenters is reported. This transformation is demonstrated in the synthesis of 3,3‐disubstituted oxindoles, which are prevalent motifs seen in numerous biologically active molecules. The method shows broad scope, proceeds in synthetically useful yields, and provides a rare means to construct stereochemically complex frameworks by nonprecious‐metal catalysis.
Type of Medium:
Online Resource
ISSN:
0044-8249
,
1521-3757
DOI:
10.1002/ange.v128.39
DOI:
10.1002/ange.201606955
Language:
English
Publisher:
Wiley
Publication Date:
2016
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514305-6
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505872-7
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1479266-7
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505867-3
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506259-7
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