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  • 1
    Online Resource
    Online Resource
    Elsevier BV ; 2022
    In:  Pediatric Clinics of North America Vol. 69, No. 2 ( 2022-04), p. 301-317
    In: Pediatric Clinics of North America, Elsevier BV, Vol. 69, No. 2 ( 2022-04), p. 301-317
    Type of Medium: Online Resource
    ISSN: 0031-3955
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2022
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  • 2
    Online Resource
    Online Resource
    Elsevier BV ; 2018
    In:  Operative Techniques in Otolaryngology-Head and Neck Surgery Vol. 29, No. 2 ( 2018-06), p. 44-50
    In: Operative Techniques in Otolaryngology-Head and Neck Surgery, Elsevier BV, Vol. 29, No. 2 ( 2018-06), p. 44-50
    Type of Medium: Online Resource
    ISSN: 1043-1810
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2018
    detail.hit.zdb_id: 2135189-2
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  • 3
    In: International Archives of Allergy and Immunology, S. Karger AG, Vol. 180, No. 1 ( 2019), p. 72-78
    Abstract: 〈 b 〉 〈 i 〉 Background: 〈 /i 〉 〈 /b 〉 Chronic rhinosinusitis (CRS) is a multifaceted disease with a significant genetic component. The importance of taste receptor signaling has recently been highlighted in CRS; single nucleotide polymorphisms (SNPs) of bitter tastant-responsive G-protein-coupled receptors have been linked with CRS and with altered innate immune responses to multiple bacterially derived signals. 〈 b 〉 〈 i 〉 Objective: 〈 /i 〉 〈 /b 〉 To determine in CRS the frequency of six SNPs in genes with known bitter tastant signaling function. 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 Genomic DNA was isolated from 74 CRS volunteers in West Virginia, and allele frequency was determined and compared with demographically matched data from the 1,000 Genomes database. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 For two SNPs in a gene recently associated with bitterant signaling regulation, RGS21, there were no associations with CRS (although the frequency of the minor allele of RGS21, rs7528947, was seen to increase with increasing Lund-Mackay CT staging score). Two TAS2R bitter taste receptor gene variants (TAS2R19 rs10772420 and TAS2R38 rs713598), identified in prior CRS genetics studies, were found to have similar associations in this study. 〈 b 〉 〈 i 〉 Conclusion: 〈 /i 〉 〈 /b 〉 Unique to our study is the establishment of an association between CRS in this patient population and GNB3 SNP rs5443, a variation in an established G protein component downstream of bitterant receptor signal transduction.
    Type of Medium: Online Resource
    ISSN: 1018-2438 , 1423-0097
    RVK:
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2019
    detail.hit.zdb_id: 1482722-0
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  • 4
    Online Resource
    Online Resource
    SAGE Publications ; 2020
    In:  Annals of Otology, Rhinology & Laryngology Vol. 129, No. 8 ( 2020-08), p. 748-754
    In: Annals of Otology, Rhinology & Laryngology, SAGE Publications, Vol. 129, No. 8 ( 2020-08), p. 748-754
    Abstract: To develop a Decision Quality (DQ) tool to measure parents’ DQ concerning ventilation tube (VT) insertion in their children. Method: Parental survey during 2017 to 2018 in a tertiary care pediatric otolaryngology clinic comparing a validated Decisional Conflict (DC) scale with a DQ instrument including Shared Decision-Making (SDM) scale, parental treatment goals, and knowledge about VT. Results: Of 100 parent participants, 83% were mothers and 14% were fathers. 94% elected VT insertion, 6% elected monitoring or deferred the decision. 44% of the patients were 〈 18 months, 42% were 19 months to 3 years, and the rest were older. The mean DC score was 8.26 out of 100 (95% CI 4.82-11.69), indicating low DC. Mean DQ score was 82.45 out of 100 (95% CI 80.18-84.72), including mean SDM of 87.71 (95% CI 83.53-91.88,), mean knowledge score of 87.5% (95% CI 84.56-91.59) and mean values score of 7.16 (95% CI 6.90-7.41). Comparisons between those who elected VT and those who did not showed that electors had lower DC scores (7.15 vs 24.74, P 〈 .001), higher DQ scores (83.00 vs 72.61, P = .028) with higher SDM scores (88.70 vs 70.22, P = .044) and higher values score (7.20 vs 6.36, P = .034). Cronbach alpha for the DQ scale was 0.76. Spearman’s rho for DQ score versus DC score was −0.458, P 〈 .001. Conclusions: DQ, as measured with this tool, was higher when parents chose to place tubes. Our DQ instrument has potential use for study of why parents may decline VT when their child meets criteria for them.
    Type of Medium: Online Resource
    ISSN: 0003-4894 , 1943-572X
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2020
    detail.hit.zdb_id: 2033055-8
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  • 5
    Online Resource
    Online Resource
    SAGE Publications ; 2023
    In:  Annals of Otology, Rhinology & Laryngology Vol. 132, No. 5 ( 2023-05), p. 558-565
    In: Annals of Otology, Rhinology & Laryngology, SAGE Publications, Vol. 132, No. 5 ( 2023-05), p. 558-565
    Abstract: To identify factors predicting success in slide tracheoplasty surgery at a regional children’s hospital and compare with available published literature. Measures: Retrospective chart review comparing demographics (age, weight) and clinical (operative and hospital course, need for additional airway intervention) factors experienced with slide tracheoplasty. Findings were compared with a systematic review of published literature. Results: Of the 16 tracheal stenosis patients in our cohort, 13 (81.3%) presented with an additional congenital or cardiovascular anomaly. When adjusted for cardiovascular anomalies, congenital tracheal stenosis patients had a mean age of 5.2 months (range 6 days-17 months), mean weight of 5.04 kg, and average ICU and hospital length of stay of 31.5 and 36.0 days, respectively. Tracheostomy was required for 4 patients and no early deaths were recorded. Of the 391 children in the grouped cohort, mean age and weight was older at 7.67 months and larger at 5.70 kg. Length of stay in both ICU and overall hospital course was 31.6 and 43.5 days, respectively. Mortality etiology for 44 patients was reported: 17 (38.6%) cardiac-related and 28 (63.6%) late mortalities. Our overall calculated mortality risk of 1.26 ( P  〈  .05) was lower than reported ratios of 2.0+. Conclusion: Despite the numerous institutional studies involving tracheal stenosis, mortality and surgical challenges remain high. Future studies with the inclusion of specific perioperative data can prove to further evaluate correlations between presentation characteristics and mortality.
    Type of Medium: Online Resource
    ISSN: 0003-4894 , 1943-572X
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2023
    detail.hit.zdb_id: 2033055-8
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  • 6
    Online Resource
    Online Resource
    Hindawi Limited ; 2018
    In:  Case Reports in Endocrinology Vol. 2018 ( 2018), p. 1-4
    In: Case Reports in Endocrinology, Hindawi Limited, Vol. 2018 ( 2018), p. 1-4
    Abstract: Background . Undifferentiated anaplastic carcinoma rarely develops from chronic hyperthyroidism. Although acute hyperthyroidism can develop prior to anaplastic transformation, chronic hyperthyroidism was thought to be a protective measure against thyroid malignancy. Methods . A 79-year-old female presented acutely to the hospital with dyspnea. She had been taking methimazole for chronic hyperthyroidism due to toxic thyroid nodules, previously biopsied as benign. Upon admission, imaging showed tracheal compression, requiring a total thyroidectomy with tracheostomy for airway management. Results . Pathology demonstrated undifferentiated anaplastic thyroid carcinoma. The patient passed away shortly after hospital discharge. Despite treatment with methimazole for many years, abrupt enlargement of her toxic multinodular goiter was consistent with malignant transformation. Chronic hyperthyroidism and toxic nodules are rarely associated with thyroid malignancy, with only one previous report documenting association with anaplastic thyroid carcinoma. Conclusion . Progressive thyroid enlargement and acute worsening of previously controlled hyperthyroidism should promote concern for disease regardless of baseline thyroid function.
    Type of Medium: Online Resource
    ISSN: 2090-6501 , 2090-651X
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2018
    detail.hit.zdb_id: 2627633-1
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  • 7
    Online Resource
    Online Resource
    Hindawi Limited ; 2018
    In:  Case Reports in Otolaryngology Vol. 2018 ( 2018-12-10), p. 1-3
    In: Case Reports in Otolaryngology, Hindawi Limited, Vol. 2018 ( 2018-12-10), p. 1-3
    Abstract: Objective . To demonstrate lateral pharyngeal wall collapse and increased apnea-hypopnea index in a child posttonsillectomy. Background . Some children have worsening of their sleep symptoms after tonsillectomy for obstructive sleep apnea. This case report demonstrates an open airway on drug-induced sleep endoscopy (DISE) in a child with tonsillar hypertrophy followed by more pronounced airway obstruction related to lateral pharyngeal wall collapse after tonsillectomy. Case Presentation . A 7-year-old boy presented with obstructive sleep apnea and underwent workup with DISE. Following adenotonsillectomy and subsequent lingual tonsillectomy with epiglottopexy, the patient’s sleep apnea symptoms and polysomnogram results worsened. Subsequent DISE showed a more narrowed oropharyngeal airway space as compared to his preoperative DISE. Discussion . Palatine tonsillar tissue may splint open the airway and prevent airway obstruction in a subset of pediatric patients. Further clinical studies are necessary to determine which children experience this phenomenon. Clinical examination using DISE can be useful in making clinical decisions prior to tonsillectomy.
    Type of Medium: Online Resource
    ISSN: 2090-6765 , 2090-6773
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2018
    detail.hit.zdb_id: 2648756-1
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  • 8
    Online Resource
    Online Resource
    Hindawi Limited ; 2018
    In:  Case Reports in Otolaryngology Vol. 2018 ( 2018), p. 1-3
    In: Case Reports in Otolaryngology, Hindawi Limited, Vol. 2018 ( 2018), p. 1-3
    Abstract: Objective . To present a rare case of a pediatric tracheocutaneous sinus years after repair of a tracheocutaneous fistula and to review management strategies. Background . A tracheocutaneous fistula is a common sequela of pediatric tracheostomy and can occur in as many as one in three pediatric patients. There is debate in the literature regarding optimal surgical management. Case Presentation . An 8-year-old girl presented to the emergency department with swelling and erythema over the anterior neck. Clinical exam and diagnostic imaging revealed an underlying tracheocutaneous sinus. Discussion . Complications following pediatric tracheostomy are common and range in complexity from stomal granulation to tracheocutaneous fistula. There is some debate regarding the optimal surgical management of children with tracheocutaneous fistula following tracheostomy. This report discusses the management of a pediatric child with an unusual tracheocutaneous sinus and reviews the various surgical techniques which have been described for definitive repair.
    Type of Medium: Online Resource
    ISSN: 2090-6765 , 2090-6773
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2018
    detail.hit.zdb_id: 2648756-1
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  • 9
    Online Resource
    Online Resource
    Elsevier BV ; 2022
    In:  International Journal of Pediatric Otorhinolaryngology Vol. 162 ( 2022-11), p. 111284-
    In: International Journal of Pediatric Otorhinolaryngology, Elsevier BV, Vol. 162 ( 2022-11), p. 111284-
    Type of Medium: Online Resource
    ISSN: 0165-5876
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2022
    detail.hit.zdb_id: 2224872-9
    detail.hit.zdb_id: 2009657-4
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  • 10
    Online Resource
    Online Resource
    Elsevier BV ; 2018
    In:  International Journal of Pediatric Otorhinolaryngology Vol. 112 ( 2018-09), p. 75-79
    In: International Journal of Pediatric Otorhinolaryngology, Elsevier BV, Vol. 112 ( 2018-09), p. 75-79
    Type of Medium: Online Resource
    ISSN: 0165-5876
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2018
    detail.hit.zdb_id: 2224872-9
    detail.hit.zdb_id: 2009657-4
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