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  • 1
    Online Resource
    Online Resource
    Multicenter study of serotype distribution of Streptococcus pneumoniae nasopharyngeal isolates from healthy children in the Russian Federation after introduction of PCV13 into the National Vaccination Calendar
    Elsevier BV ; 2020
    In:  Diagnostic Microbiology and Infectious Disease Vol. 96, No. 1 ( 2020-01), p. 114914-
    Details
    In: Diagnostic Microbiology and Infectious Disease, Elsevier BV, Vol. 96, No. 1 ( 2020-01), p. 114914-
    Type of Medium: Online Resource
    ISSN: 0732-8893
    URL: Article
    DOI: 10.1016/j.diagmicrobio.2019.114914
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2020
    detail.hit.zdb_id: 2026024-6
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  • 2
    Online Resource
    Online Resource
    The history of the creation of special temperature measurement devices in humans
    Consilium Medicum ; 2022
    In:  Pediatrics. Consilium Medicum , No. 2 ( 2022-07-30), p. 140-146
    Details
    In: Pediatrics. Consilium Medicum, Consilium Medicum, , No. 2 ( 2022-07-30), p. 140-146
    Abstract: Thermometry has firmly entered our lives. Today, we habitually put the thermometer in the armpit and evaluate the result after 10 min. At the same time, doubts often arise concerning the interpretation of the measurement results, especially in case of severe infections, impaired general well-being, feeling feverish or hot and headache. This article deals with thermometry in light of history of the development of medical thermometers and the assessment of the different types of fever before the development of new technical possibilities for assessing body temperature. In children especially young children, high fever is not only a symptom of the disease, but also a dangerous factor for the development of complications. The control of body temperature, the detection of the periods of hyperthermia, the efficacy of antipyretic drugs can alleviate the course of the disease and prevent the development of terrible complications (dehydration, cerebral edema, convulsions, etc.). Today, in the period of rapid development of computer technologies, the possibilities of thermometry are also changing. The application of small and lightweight smart devices allows to control the change in child's body temperature, especially during the illness, and to respond in a timely manner to changes.
    Type of Medium: Online Resource
    ISSN: 2658-6622 , 2658-6630
    URL: Article
    DOI: 10.26442/26586630.2022.2.201419
    Language: Unknown
    Publisher: Consilium Medicum
    Publication Date: 2022
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  • 3
    Online Resource
    Online Resource
    The role of ω3-polyunsaturated fatty acids in the prevention of atherogenic cardiovascular diseases starting in childhood
    Consilium Medicum ; 2022
    In:  Pediatrics. Consilium Medicum , No. 1 ( 2022-05-10), p. 33-38
    Details
    In: Pediatrics. Consilium Medicum, Consilium Medicum, , No. 1 ( 2022-05-10), p. 33-38
    Abstract: Diseases of the cardiovascular system are one of the main causes of morbidity, disability and mortality. One of the most significant risk factors for their development is atherogenic dyslipidemia. Atherosclerotic vascular damage occurs long before clinical manifestation and often begins to progress as early as childhood. This is why children represent the most important cohort for the prevention of cardiovascular diseases of atherosclerotic genesis. Studies show that taking ₃-polyunsaturated fatty acids reduces the risk of atherosclerotic vascular disease in adults and children. The effect is achieved by multidirectional effects on risk factors such as insulin resistance, obesity, diabetes mellitus, dyslipidaemia, arterial hypertension, inflammation and endothelial dysfunction. In children with primary dyslipidemia (heterozygous familial hypercholesterolemia) taking ₃-polyunsaturated fatty acids leads to normalization of serum triglycerides and a moderate decrease in total cholesterol and low-density lipoprotein cholesterol. The most significant therapeutic and prophylactic effects are observed in patients with secondary dyslipidemias caused by obesity and diabetes mellitus, when, besides the decrease in triglycerides and the increase in HDL cholesterol, ₃-polyunsaturated fatty acids increase the insulin sensitivity of cells and tissue, body weight reduction, increase in muscle mass, stabilization of blood pressure and improvement of liver function are observed. Considering pleiotropic protective effect and good tolerability, ₃-polyunsaturated fatty acids can be widely used for primary and secondary prevention of atherosclerotic cardiovascular diseases in children and adolescents.
    Type of Medium: Online Resource
    ISSN: 2658-6622 , 2658-6630
    URL: Article
    DOI: 10.26442/26586630.2022.1.201434
    Language: Unknown
    Publisher: Consilium Medicum
    Publication Date: 2022
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  • 4
    Online Resource
    Online Resource
    The Effects of Separate and Combined Treatment of Male Rats with Type 2 Diabetes with Metformin and Orthosteric and Allosteric Agonists of Luteinizing Hormone Receptor on Steroidogenesis and Spermatogenesis
    MDPI AG ; 2021
    In:  International Journal of Molecular Sciences Vol. 23, No. 1 ( 2021-12-24), p. 198-
    Details
    In: International Journal of Molecular Sciences, MDPI AG, Vol. 23, No. 1 ( 2021-12-24), p. 198-
    Abstract: In men with type 2 diabetes mellitus (T2DM), steroidogenesis and spermatogenesis are impaired. Metformin and the agonists of luteinizing hormone/human chorionic gonadotropin(hCG)-receptor (LH/hCG-R) (hCG, low-molecular-weight allosteric LH/hCG-R-agonists) can be used to restore them. The aim was to study effectiveness of separate and combined administration of metformin, hCG and 5-amino-N-tert-butyl-2-(methylsulfanyl)-4-(3-(nicotinamido)phenyl)thieno[2,3-d]pyrimidine-6-carboxamide (TP3) on steroidogenesis and spermatogenesis in male rats with T2DM. hCG (15 IU/rat/day) and TP3 (15 mg/kg/day) were injected in the last five days of five-week metformin treatment (120 mg/kg/day). Metformin improved testicular steroidogenesis and spermatogenesis and restored LH/hCG-R-expression. Compared to control, in T2DM, hCG stimulated steroidogenesis and StAR-gene expression less effectively and, after five-day administration, reduced LH/hCG-R-expression, while TP3 effects changed weaker. In co-administration of metformin and LH/hCG-R-agonists, on the first day, stimulating effects of LH/hCG-R-agonists on testosterone levels and hCG-stimulated expression of StAR- and CYP17A1-genes were increased, but on the 3–5th day, they disappeared. This was due to reduced LH/hCG-R-gene expression and increased aromatase-catalyzed estradiol production. With co-administration, LH/hCG-R-agonists did not contribute to improving spermatogenesis, induced by metformin. Thus, in T2DM, metformin and LH/hCG-R-agonists restore steroidogenesis and spermatogenesis, with metformin being more effective in restoring spermatogenesis, and their co-administration improves LH/hCG-R-agonist-stimulating testicular steroidogenesis in acute but not chronic administration.
    Type of Medium: Online Resource
    ISSN: 1422-0067
    URL: Article
    DOI: 10.3390/ijms23010198
    Language: English
    Publisher: MDPI AG
    Publication Date: 2021
    detail.hit.zdb_id: 2019364-6
    SSG: 12
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  • 5
    Online Resource
    Online Resource
    Fig. 13. Atopic dermatitis in the area of the folds of the wrist joint. Before treatment (а) and 3 months later (b).
    ECO-Vector LLC ; 2023
    In:  Russian Journal of Skin and Venereal Diseases Vol. 26, No. 1 ( 2023-04-07), p. 25-39
    Details
    In: Russian Journal of Skin and Venereal Diseases, ECO-Vector LLC, Vol. 26, No. 1 ( 2023-04-07), p. 25-39
    Abstract: BACKGROUND: Atopic dermatitis is a chronic, relapsing and severely itchy dermatitis that usually occurs in childhood and has a characteristic age-related distribution. Atopic dermatitis is relatively frequent, affecting 1020% of children in developed countries. Atopic dermatitis in children associated with poor school performance, low self-esteem and family problems. Recent studies show importance in atopic dermatitis pathogenesis of protein filaggrin and modulation of its activity may be a promising direction in the pathogenic therapy of atopic dermatitis. AIM: to study the effect of a cream for dry, sensitive and atopic skin with a modulator of filaggrin activity on the course of mild and moderate atopic dermatitis. MATERIAL AND METHODS: An open, prospective, multicentre, non-comparative, single-group clinical trial was organized to test the effectiveness of a cream with a filaggrin activity modulator. The study was on outpatients in the participated centers and included 5 visits with a screening visit 1, and 5th visit ― therapy completion. Cream was used for 12 weeks. In total, the study involved 60 children aged 3 to 18 years with diagnoses of atopic dermatitis of mild and moderate severity. The severity of atopic dermatitis was measured with the SCORAD, EASI, IGA scales, also measured was skin pH and transepidermal water loss (TEWL), as well as the severity of xerosis according to visual analogue scale. RESULTS: The severity of atopic dermatitis in children whose therapy regimens included Admera cream decreased by 19.6 points according to the SCORAD index, including in children who did not receive mometasone furoate in the therapy schemes, the SCORAD index decreased statistically significantly compared to the baseline data (p 0.001). The overall decline in the EASI index ― by 3.0 points, the IGA global assessment index ― by 2.0 points, the severity of xerosis decreased by 3 points (in all cases, p 0.001). Transepidermal water loss decreased (by 4.5 g/m2 per hour, p 0.001); Skin pH did not change (difference 0.02, p=0.34). The smell was rated as "excellent" by 86.7% (95% CI 75.494.1), the consistency ― by 83.3% (95% CI 71.591.7) of the respondents, and overall satisfaction was noted by ― 88.3% (95% CI 77.495.2) of the respondents. CONCLUSION: Сream for dry and sensitive skin with a modulator of filaggrin activity during the study showed good efficacy and tolerability and can be used in atopic dermatitis treatment regimens as a basic care product, both during exacerbation and remission.
    Type of Medium: Online Resource
    ISSN: 2412-9097 , 1560-9588
    URL: Issue
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    URL: Article
    DOI: 10.17816/dv.11
    DOI: 10.17816/dv122220
    DOI: 10.17816/dv122220-1783962
    DOI: 10.17816/dv122220-1783969
    DOI: 10.17816/dv122220-1783976
    DOI: 10.17816/dv122220-1783984
    DOI: 10.17816/dv122220-1783991
    DOI: 10.17816/dv122220-1784001
    DOI: 10.17816/dv122220-1784007
    DOI: 10.17816/dv122220-1784013
    DOI: 10.17816/dv122220-1784030
    DOI: 10.17816/dv122220-1784037
    DOI: 10.17816/dv122220-1784044
    DOI: 10.17816/dv122220-1784051
    DOI: 10.17816/dv122220-1784059
    Language: Unknown
    Publisher: ECO-Vector LLC
    Publication Date: 2023
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  • 6
    Online Resource
    Online Resource
    BH4-deficient hyperphenylalaninemia in Russia
    Public Library of Science (PLoS) ; 2021
    In:  PLOS ONE Vol. 16, No. 4 ( 2021-4-6), p. e0249608-
    Details
    In: PLOS ONE, Public Library of Science (PLoS), Vol. 16, No. 4 ( 2021-4-6), p. e0249608-
    Abstract: A timely detection of patients with tetrahydrobiopterin (BH 4 ) -deficient types of hyperphenylalaninemia (HPABH 4 ) is important for assignment of correct therapy, allowing to avoid complications. Often HPABH 4 patients receive the same therapy as phenylalanine hydroxylase (PAH) -deficiency (phenylketonuria) patients—dietary treatment—and do not receive substitutive BH 4 therapy until the diagnosis is confirmed by molecular genetic means. In this study, we present a cohort of 30 Russian patients with HPABH 4 with detected variants in genes causing different types of HPA. Family diagnostics and biochemical urinary pterin spectrum analyses were carried out. HPABH 4 A is shown to be the prevalent type, 83.3% of all HPABH 4 cases. The mutation spectrum for the PTS gene was defined, the most common variants in Russia were p.Thr106Met—32%, p.Asn72Lys—20%, p.Arg9His—8%, p.Ser32Gly—6%. We also detected 7 novel PTS variants and 3 novel QDPR variants. HPABH 4 prevalence was estimated to be 0.5–0.9% of all HPA cases in Russia, which is significantly lower than in European countries on average, China, and Saudi Arabia. The results of this research show the necessity of introducing differential diagnostics for HPABH 4 into neonatal screening practice.
    Type of Medium: Online Resource
    ISSN: 1932-6203
    URL: Article
    URL: Article
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    URL: Article
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    URL: Article
    DOI: 10.1371/journal.pone.0249608
    DOI: 10.1371/journal.pone.0249608.t001
    DOI: 10.1371/journal.pone.0249608.t002
    DOI: 10.1371/journal.pone.0249608.t003
    DOI: 10.1371/journal.pone.0249608.t004
    DOI: 10.1371/journal.pone.0249608.t005
    DOI: 10.1371/journal.pone.0249608.t006
    DOI: 10.1371/journal.pone.0249608.t007
    Language: English
    Publisher: Public Library of Science (PLoS)
    Publication Date: 2021
    detail.hit.zdb_id: 2267670-3
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  • 7
    Online Resource
    Online Resource
    A Method for Preventing Scarring from Surgical Treatment of Glaucoma
    VSMU N.N. Burdenko ; 2017
    In:  Vestnik of Experimental and Clinical Surgery Vol. 9, No. 1 ( 2017-02-23), p. 81-
    Details
    In: Vestnik of Experimental and Clinical Surgery, VSMU N.N. Burdenko, Vol. 9, No. 1 ( 2017-02-23), p. 81-
    Abstract: Актуальность Улучшение технических аспектов выполнения хирургических вмешательств при глаукоме позволило до-биться снижения внутриглазного давления в раннем послеоперационном периоде, а также уменьшения частоты развитияпослеоперационных осложнений. Актуальным является вопрос избыточного рубцевания в области оперативного вме-шательства, в результате которого снижается гипотензивный эффект операции, а в отдаленном послеоперационномпериоде, в некоторых случаях, сводит на нет результаты операции.Цель исследования Разработать способ повышения эффективность антиглаукоматозной операции, при которой для про-филактики рубцевания используют синтетический материал Gore-tex.Материалы и методы Эксперимент проведен на 30 животных, которые были разделены на две группы, контрольную - 15животных, оперированных по стандартной методике глубокой склерэктомии по С. Н. Федеорову (ГСЭ), и опытную - 15животных, которым при выполнении ГСЭ под поверхностный склеральный лоскут укладывалась полоска, выкроенная измембраны Gore-tex.Результаты и их обсуждение Исследование результатов имплантации синтетического материала Gore-tex при про-ведении ГСЭ выявило снижение частоты рецидива подъёма внутриглазного давления (ВГД) в позднем послеоперационномпериоде, уменьшение процессов рубцевания. Морфологические исследования показали, что в контрольной группе через 6месяцев в зоне оперативного вмешательства определялось разрастание грубой соединительной ткани с незначительнымколичеством фибробластов и новообразованных сосудов. Уровень внутриглазного давления (ВГД) в контрольной группеживотных через 6 месяцев составил 11.0 мм рт. ст, т. е. вернулся к дооперационному уровню, тогда как в опытной группечерез 6 месяцев после хирургического вмешательства имплант окружен тонкой фиброзной капсулы, вокруг имплантаиме-ется полость до 20 мкм, заполненная жидкостью, которая сообщается с супрахориоидальным и субтеноновым простран-ством. Отмечались дополнительные полости между отдельными волокнами коллагена, также заполненные жидкостью.Уровень ВГД через 6 месяцев после проведения оперативного вмешательства по предлагаемой методике составил 9,0 ммрт ст, что коррелировало с морфологическими изменениями в зоне вмешательства.Заключение Полученные результаты свидетельствуют о том, что использование мембраны Gore-tex снижает процессырубцевания в зоне оперативного вмешательства и способствует повышению гипотензивного эффекта существующегохирургического лечения.Ключевые слова глаукома, профилактика рубцевания, хирургическое лечение.
    Type of Medium: Online Resource
    ISSN: 2409-143X , 2070-478X
    URL: Article
    DOI: 10.18499/2070-478X-2016-9-1-81-88
    Language: Unknown
    Publisher: VSMU N.N. Burdenko
    Publication Date: 2017
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  • 8
    Online Resource
    Online Resource
    Post-covid syndrome in children in rare cases of COVID-19
    Consilium Medicum ; 2022
    In:  Pediatrics. Consilium Medicum , No. 1 ( 2022-05-10), p. 8-14
    Details
    In: Pediatrics. Consilium Medicum, Consilium Medicum, , No. 1 ( 2022-05-10), p. 8-14
    Abstract: Post-covid syndrome (PCS) is a symptom complex that occurs during and after COVID-19 lasting more than 12 weeks, which is not a possible disease. The clinical manifestations of PCS are many-sided, under their mask or manifestations or exacerbations of chronic organic activity, the trigger of which was the virus, are hidden. PCS is a diagnosis of exclusion. The main manifestations of PCS: autonomic dysregulation, cognitive and psycho-emotional disorders, disorders of the respiratory system, cardiovascular, digestive systems. Direct pathogenic factors, the main neurological manifestations are PCS of preservation of brain hypoperfusion, hypoxia and hypoxemia, resulting in energy deficiency of neuronal structures, violation of the probable, as well as virus-induced structural detection of neurons in the cortex and subcortical structures of the brain. The severity and duration of exposure appear to be increasingly dependent on the body's response to SARS-CoV-2. PCS has a different severity of severity in recovered patients and does not always depend on the severity of the acute period. Timely examination with differential diagnosis allows not only to make a diagnosis, but also to recommend therapy with a personalized approach to the correction of PCS.
    Type of Medium: Online Resource
    ISSN: 2658-6622 , 2658-6630
    URL: Article
    DOI: 10.26442/26586630.2022.1.201515
    Language: Unknown
    Publisher: Consilium Medicum
    Publication Date: 2022
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  • 9
    Online Resource
    Online Resource
    Mysterious 〈i〉Akkermansia muciniphila〈/i〉. What do we know about it? A review
    Consilium Medicum ; 2023
    In:  Pediatrics. Consilium Medicum , No. 1 ( 2023-06-06), p. 74-80
    Details
    In: Pediatrics. Consilium Medicum, Consilium Medicum, , No. 1 ( 2023-06-06), p. 74-80
    Abstract: "Microbes and humans" is a topic that has been continuously studied over the past decade. Numerous recent studies show that quantitative and qualitative changes in the composition of the gastrointestinal tract microbiota have direct and indirect effects on metabolic changes in the host. Many countries are researching the microbiome and opportunities to influence health through environmental modification and introducing a probiotic, a metabiotic, or a synbiotic into the body. Considerable attention is paid to metabolic disorders and obesity, as these are issues that are becoming a progressive global epidemic. More than 2 billion people are overweight and obese, and many experts continue to look for promising methods to combat it. A special group of high risk for obesity is children. Statistics show a steady upward trend of obesity in children. Over the past 10 years, this trend has shown a rapid pace: from 6.7%, according to 2010, to 9.1% by 2020. In this context, Akkermansia muciniphila attracts special attention among all bacteria inhabiting the gastrointestinal tract due to its potential to treat insulin resistance, obesity, and diabetes mellitus. This article reviews new research on the A. muciniphila effects on the host and ways to correct metabolism using probiotics.
    Type of Medium: Online Resource
    ISSN: 2658-6622 , 2658-6630
    URL: Article
    DOI: 10.26442/26586630.2023.1.202190
    Language: Unknown
    Publisher: Consilium Medicum
    Publication Date: 2023
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  • 10
    Online Resource
    Online Resource
    Pharynx infectious and inflammatory diseases local etiotropic therapy efficacy comprehensive assessment in preschool and primary school-age children
    Consilium Medicum ; 2023
    In:  Pediatrics. Consilium Medicum , No. 3 ( 2023-10-04), p. 135-146
    Details
    In: Pediatrics. Consilium Medicum, Consilium Medicum, , No. 3 ( 2023-10-04), p. 135-146
    Abstract: Background. The oropharyngeal microbiota is important in maintaining resistance, eliminating viruses and regulating local protective reactions in response to inflammation in acute respiratory infections. Aim. To evaluate of the effect of topical etiotropic therapy on clinical manifestations, elimination of viruses and on oropharyngeal microbiota in the treatment of acute infectious inflammation of the throat that occurred as part of acute respiratory infections in children aged 510 years. Materials and methods. 120 outpatient patients randomized into 3 equal groups were treated for 7 days: in Group 1 0.2% hexethidine-containing aerosol, in Group 2 0.03 mg combined spray gramicidin S and 0.1 mg cetylpyridinium chloride, in Group 3 0.01% topical solution containing benzyldimethyl-myristoylamino-propylammonium. Changes in the severity of clinical manifestations were compared (integral indicator modified Tonsillopharyngitis Severity Score TSSm for children, the severity of the "sore throat" symptom on the WongBaker scale, the severity of local signs of inflammation according to pharyngoscopy data) in groups at Visit 2 (day 51) and Visit 3 (day 121) compared with the Visit 1. The elimination of acute respiratory infection pathogens was evaluated: polymerase chain reaction (PCR) of oropharyngeal smears obtained on days 1, 3 and 5 (1) PCR-1, PCR-2, PCR-3 respectively, with the detection of 12 respiratory viruses, including SARS-CoV-2. The state of the microbiota was assessed by sequencing the full-size 16S gene in samples obtained before and after treatment 1st and 12th (1) days, and compared with 19 indicators in healthy. Results. By Visit 3, the decrease in TSSm indicators was: 4.01.07 in Group 1; 5.01.48 in Group 2 and 4.01.02 in Group 3. The intergroup differences between Group 2 and 1, Group 2 and 3 were statistically significant (p0.05). The severity of sore throat by Visit 3 decreased in groups 1, 2 and 3 respectively by 2.00.90, 2.50.61 and 2.10.60, intergroup differences between groups 2 and 1, 2 and 3 had statistical significance at p0.05. The time to achieve complete relief of the disease according to the TSSm indicator was (day, MSE): 16.61.47 in Group 1; 11.91.13 in Group 2 and 12.41.38 in Group 3, intergroup differences (groups 1 and 2) are significant, p0.05. The time of complete relief from sore throat for groups 13 was 12.60.96, 8.00.87 and 9.41.01 respectively, intergroup differences (groups 1 and 2) were significant, p0.05. By Visit 2, the proportion of patients with a negative PCR result increased in Group 1 by 25%, in Group 2 by 43% and in Group 3 by 38%, which corresponded to the elimination of 81, 92 and 74% of viruses detected in groups according to PCR-1 and PCR-2. The microbiota of participants in all groups before treatment differed from the microbiota of healthy in terms of alpha and beta diversity, as well as in terms of indicators obtained by the NearesBalance method. After completion of treatment, changes in the microbiota in terms of beta diversity were observed in all groups compared to the initial state. In contrast to groups 1 and 3, in Group 2 there were statistically significant changes in species-level balances between groups of microbes that distinguish between sick and healthy, towards indicators of healthy. Conclusion. Topical etiotropic medications provide rapid relief of complaints and local signs of inflammation in the treatment of patients aged 510 years with sore throat in acute respiratory infections and contribute to the rapid elimination of pathogens of acute respiratory infections. A combined preparation containing an antiseptic and a bacteriocin-like antimicrobial peptide gramicidin S provides a more pronounced therapeutic effect at an earlier time and the elimination of 90% of all respiratory viruses, including SARS-CoV-2, by the fifth day of therapy, and also has the most sparing effect on the oropharyngeal microbiota compared to antiseptic monopreparations, which may explain its more pronounced anti-inflammatory effect.
    Type of Medium: Online Resource
    ISSN: 2658-6622 , 2658-6630
    URL: Article
    DOI: 10.26442/26586630.2023.3.202304
    Language: Unknown
    Publisher: Consilium Medicum
    Publication Date: 2023
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