In:
Heterocyclic Communications, Walter de Gruyter GmbH, Vol. 21, No. 1 ( 2015-2-1), p. 13-18
Abstract:
A series of N -(arylpiperazinyl)acetamide derivatives of 1,3- and 3,7-dimethyl-1 H -purine-2,6(3 H ,7 H )-dione was synthesized and biologically evaluated in in vitro competition binding experiments for serotonin 5-HT 6 , 5-HT 7 , and dopamine D 2 receptors. The structure-affinity relationships for this group of compounds allowed for determination of structural features responsible for receptor affinity. Among the investigated derivatives, compounds 5 and 12 with (2,3-dichlorophenyl)piperazine moiety were classified as potent dual 5-HT 6 /D 2 receptors ligands, whereas compound 4 , with 4-(benzo[ d ]isothiazol-3-yl)piperazine moiety, and compounds 8 and 15 , with (2,3-dichlorophenyl)piperazine moiety, were classified as potent D 2 receptor ligands.
Type of Medium:
Online Resource
ISSN:
2191-0197
,
0793-0283
DOI:
10.1515/hc-2014-0200
Language:
English
Publisher:
Walter de Gruyter GmbH
Publication Date:
2015
detail.hit.zdb_id:
2598389-1
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