In:
The Journal of Laryngology & Otology, Cambridge University Press (CUP), Vol. 125, No. 3 ( 2011-03), p. 227-230
Kurzfassung:
This study aimed to demonstrate the histological and immunohistological features of skin biopsy specimens from patients complaining of isolated itching of the external auditory canal. Materials and methods: A prospective, case–control study was performed of 24 patients undergoing evaluation for contact dermatitis of the external auditory canal, and 24 controls. Skin biopsies were examined histologically by a single, blinded dermatopathologist, using light microscopy, to determine histopathological characteristics. The immunohistological presence of the antimicrobial peptides human β-defensin-3 and LL-37 cathelicidin was also assessed. Findings for patients and controls were compared. Results: There was a statistically significant difference in the degree of inflammation, comparing patients and controls ( p 〈 0.05). There was no significant difference in the presence of spongiotic changes, comparing patients and controls ( p 〉 0.05). Furthermore, the patients' skin biopsies did not show pronounced expression of human β-defensin-3 or LL-37 cathelicidin. Conclusion: Histological and immunohistological examination of skin biopsies from cases of isolated itching of the external auditory canal did not support a diagnosis of dermatitis.
Materialart:
Online-Ressource
ISSN:
0022-2151
,
1748-5460
DOI:
10.1017/S0022215110002161
Sprache:
Englisch
Verlag:
Cambridge University Press (CUP)
Publikationsdatum:
2011
ZDB Id:
2013209-8
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