In:
PeerJ, PeerJ, Vol. 11 ( 2023-02-13), p. e14792-
Abstract:
We recently studied the association between various human leukocyte antigen (HLA) alleles and end-stage renal disease (ESRD). According to our analysis, HLA-B*50 and HLA-DQA1*3 alleles were positively associated with ESRD, while B*40, DRB1*12, DRB1*13, and DQA1*6 alleles were negatively associated with ESRD. However, a single case-control study does not have enough statistical power to evaluate the possible impact of genetic polymorphism on any disease. Hence, the main objective of this meta-analysis is to determine the association between these abovementioned HLA alleles and ESRD. Design MEDLINE/PubMed, EMBASE, Web of Science, and Cochrane databases were searched through December 2020 for case-control studies on the associations between HLA polymorphisms and ESRD. Independent reviewers screened the texts of potentially eligible studies and assessed the risk of bias. The meta-analysis was conducted based on the checklists and guidelines based on PRISMA. Results We identified 26 case-control studies comprising 1,312 ESRD and 3,842 healthy subjects. A non-significant positive association was observed between HLA-B*50 (OR = 1.02, 95% CI [0.90, 1.24]), HLA-B*40 (OR = 1.75, 95% CI [0.98, 3.2] ), HLA-DQA1*3, (OR = 1.17, 95% CI [0.74, 1.84]), DRB1*12 (OR = 1.05, 95% CI [0.94, 1.18] ) alleles and ESRD. In addition, a non-significant negative association was observed between HLA-DRB1*13 (OR = 0.90, CI [0.81, 1.01]), HLA-DQB1*6 (OR = 0.79, 95% CI [0.58, 1.07] ) alleles and ESRD. Conclusions Our meta-analysis indicates no significant association between HLA-B*50, HLA-DQA1*3, B*40, DRB1*12, DRB1*13, and DQA1*6 alleles and ESRD. Further studies with larger sample sizes and adjustments for confounders are required to confirm these conclusions.
Type of Medium:
Online Resource
ISSN:
2167-8359
DOI:
10.7717/peerj.14792/fig-1
DOI:
10.7717/peerj.14792/fig-2
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10.7717/peerj.14792/fig-3
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10.7717/peerj.14792/fig-4
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10.7717/peerj.14792/fig-5
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10.7717/peerj.14792/fig-6
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10.7717/peerj.14792/fig-7
DOI:
10.7717/peerj.14792/table-1
DOI:
10.7717/peerj.14792/supp-1
DOI:
10.7717/peerj.14792/supp-2
DOI:
10.7717/peerj.14792/supp-3
DOI:
10.7717/peerj.14792/supp-4
DOI:
10.7717/peerj.14792/supp-5
DOI:
10.7717/peerj.14792/supp-6
DOI:
10.7717/peerj.14792/supp-7
DOI:
10.7717/peerj.14792/supp-8
DOI:
10.7717/peerj.14792/supp-9
Language:
English
Publisher:
PeerJ
Publication Date:
2023
detail.hit.zdb_id:
2703241-3
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