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  • 1
    Online Resource
    Online Resource
    Properties of circulating leukocytes in spontaneously hypertensive rats
    Canadian Science Publishing ; 1995
    In:  Biochemistry and Cell Biology Vol. 73, No. 7-8 ( 1995-07-01), p. 491-500
    Details
    In: Biochemistry and Cell Biology, Canadian Science Publishing, Vol. 73, No. 7-8 ( 1995-07-01), p. 491-500
    Abstract: The factors responsible for predisposition to progressive organ injury and vascular complications in arterial hypertension are uncertain. Recent evidence shows that leukocytes participate in cardiovascular conditions for which hypertension is a risk factor. Therefore, there is a need to define the properties of circulating leukocytes in hypertensives. There are about twice as many circulating leukocytes in spontaneous hypertensive rats (SHRs) compared with their normotensive controls, the Wistar–Kyoto rats (WKYs). The SHR neutrophils are viscoelastic and similar to neutrophils in WKYs but exhibit lower deformability in short-term elastic deformation. Mature SHRs have elevated levels of spontaneous pseudopod formation. Mild stimulation with N-formyl-Met-Leu-Phe or platelet-activating factor (10 −8  M) results in a significantly enhanced level of neutrophil pseudopod formation in SHRs but not in WKYs. SHRs exhibit higher levels of spontaneous superoxide formation. Alkaline phosphatase content of individual circulating neutrophils in SHRs is on average lower while plasma levels of alkaline phosphatase in the same samples are elevated in the SHRs. Spontaneous degranulation of SHR neutrophils is also detectable with myeloperoxidase measurements. Such activity of circulating leukocytes poses a significant risk for vascular cytotoxicity in the hypertensive rats.Key words: neutrophil, degranulation, alkaline phosphatase, myeloperoxidase, nitro blue tetrazolium reduction, rheological properties, adhesion.
    Type of Medium: Online Resource
    ISSN: 0829-8211 , 1208-6002
    URL: Article
    DOI: 10.1139/o95-054
    Language: English
    Publisher: Canadian Science Publishing
    Publication Date: 1995
    SSG: 12
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  • 2
    Online Resource
    Online Resource
    Microvascular tone in a skeletal muscle of spontaneously hypertensive rats.
    Ovid Technologies (Wolters Kluwer Health) ; 1987
    In:  Hypertension Vol. 9, No. 2 ( 1987-02), p. 164-171
    Details
    In: Hypertension, Ovid Technologies (Wolters Kluwer Health), Vol. 9, No. 2 ( 1987-02), p. 164-171
    Abstract: We studied the degree of arteriolar smooth muscle constriction in the spinotrapezius muscle microcirculation of spontaneously hypertensive rats and their normotensive controls, Wistar-Kyoto rats. The constriction was expressed in the form of a nondimensional tone as the difference between steady state and dilated diameter (after papaverine treatment) divided by the dilated diameter. Both animal strains showed on average a progressive increase of tone toward the more distal arterioles, with a peak tone being reached in the transverse arterioles. Tone values in the hypertensive animals were consistently elevated. The number of arterioles that had more than 5% tone (so-called responder arterioles) was higher in the hypertensive animals. These studies suggest that, besides the anatomical adjustments documented earlier in our laboratory in the arteriolar network of this muscle, functional adjustments in the form of an elevated microvascular tone are associated with the elevated resistance in spontaneously hypertensive rats.
    Type of Medium: Online Resource
    ISSN: 0194-911X , 1524-4563
    URL: Article
    DOI: 10.1161/01.HYP.9.2.164
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 1987
    detail.hit.zdb_id: 2094210-2
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  • 3
    Online Resource
    Online Resource
    Impaired leukocyte-endothelial cell interaction in spontaneously hypertensive rats.
    Ovid Technologies (Wolters Kluwer Health) ; 1994
    In:  Hypertension Vol. 24, No. 6 ( 1994-12), p. 719-727
    Details
    In: Hypertension, Ovid Technologies (Wolters Kluwer Health), Vol. 24, No. 6 ( 1994-12), p. 719-727
    Abstract: Hypertension is associated with a progressive organ injury whose etiology remains largely speculative. An increasing database shows that activated leukocytes, while affording an important immune protection, may be a contributing factor to several of the pathogenetic features of the hypertension syndrome. The purpose of this study was to determine the extent to which the glucocorticoid pathway may be involved in the atypical kinetics of leukocytes in spontaneously hypertensive rats (SHR) compared with normotensive Wistar-Kyoto (WKY) rats. The typical venular leukocyte adhesion induced by histamine application was significantly lower in SHR, and a comparison of normalized leukocyte rolling velocity (VWBC/VRBC) showed the values to be significantly higher in SHR relative to WKY controls. This abnormal trend in adherent leukocyte numbers and in VWBC/VRBC values could be counteracted when SHR were pretreated with RU 486, a synthetic glucocorticoid inhibitor, and restored to the levels observed in WKY rats. Anti-P-selectin monoclonal antibody (PB1.3) attenuated in SHR and WKY rats the increment of adherent leukocyte numbers as well as the decrement of VWBC/VRBC value that developed under combined histamine and RU 486 superfusion. Furthermore, an anti-intercellular adhesion molecule-1 monoclonal antibody (1A29) served to attenuate the increment of adherent leukocyte number induced by a combination of histamine and RU 486 superfusion in WKY rats and SHR. The results indicate that the deficient leukocyte-endothelial cell interaction in SHR can be circumvented by a glucocorticoid inhibitor.
    Type of Medium: Online Resource
    ISSN: 0194-911X , 1524-4563
    URL: Article
    DOI: 10.1161/01.HYP.24.6.719
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 1994
    detail.hit.zdb_id: 2094210-2
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  • 4
    Online Resource
    Online Resource
    Mechanisms of cell injury in rat mesentery and cremaster muscle
    American Physiological Society ; 1998
    In:  American Journal of Physiology-Heart and Circulatory Physiology Vol. 274, No. 3 ( 1998-03-01), p. H1009-H1015
    Details
    In: American Journal of Physiology-Heart and Circulatory Physiology, American Physiological Society, Vol. 274, No. 3 ( 1998-03-01), p. H1009-H1015
    Abstract: The events responsible for cell injury after a tissue stimulation are only incompletely understood. The purpose of this study was to examine mechanisms of cell injury in two tissues, rat mesentery and cremaster muscle, after tissue stimulation with N-formylmethionyl-leucyl-phenylalanine (FMLP) and platelet-activating factor (PAF). The response was studied in the same animal in random order using normal and leukopenic rats. The tissues were exteriorized after pentobarbital anesthesia. Five to six vascularized areas were chosen in each tissue, and cell injury and hydroperoxide production were assessed visually by continuous superfusion with 1 μM propidium iodide and 5 μM dichlorofluorescin diacetate (DCFH), respectively. FMLP (1 × 10 −8 M) and then PAF (1 × 10 −8 M) were added to the superfusate, and measurements were made at several time points. The second tissue was then examined using the same protocol. In the cremaster, there was little hydroperoxide production, and the tissue injury was eliminated after leukopenia. Leukopenia had no effect on tissue injury in the mesentery. Although hydroperoxide production was observed, there was no correlation between it and the tissue injury. The level of preactivation showed no correlation with either tissue injury or hydroperoxide production. In light of these results, mast cell degranulation may be an important mechanism of tissue injury in the mesentery.
    Type of Medium: Online Resource
    ISSN: 0363-6135 , 1522-1539
    URL: Article
    DOI: 10.1152/ajpheart.1998.274.3.H1009
    RVK:
    WA 15000
    Language: English
    Publisher: American Physiological Society
    Publication Date: 1998
    detail.hit.zdb_id: 1477308-9
    SSG: 12
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  • 5
    Online Resource
    Online Resource
    SOME EFFECTS OF PROTEOLYTIC INHIBITORS ON TISSUE INJURY AND SYSTEMIC ANAPHYLAXIS
    Rockefeller University Press ; 1961
    In:  The Journal of Experimental Medicine Vol. 113, No. 2 ( 1961-02-01), p. 437-450
    Details
    In: The Journal of Experimental Medicine, Rockefeller University Press, Vol. 113, No. 2 ( 1961-02-01), p. 437-450
    Abstract: A study was made of the development of various forms of local and systemic injury in animals treated with inhibitors of proteolytic activity. The agents used were tosylarginine methyl ester (TAME), epsilon aminocaproic acid (EACA), and soybean trypsin inhibitor (SBTI). 1. Hemorrhagic necrosis in the skin of the rabbit following intradermal epinephrine in combination with bacterial endotoxin (either intravenous or local) was clearly suppressed by EACA, TAME, and SBTI, given systemically. Tosylarginine (TA) was ineffective. 2. No effect was observed on the classical Shwartzman reaction, the local Arthus phenomenon, or inflammation induced by xylene. 3. The lethal effects of systemic anaphylaxis in the mouse, acute endotoxemia in the rat and mouse, and drum shock in the rat are suppressed by EACA and TAME. 4. There was no effect on the generalized Shwartzman phenomenon in the rabbit and on anaphylaxis in the guinea pig. 5. The effects of EACA or TAME on the injury reactions under investigation were not due to a pharmacological or chemical action on vascular behavior per se. 6. The data provide corroborative evidence for a proteolytic step in injury phenomena which may be mediated through some common activation system. 7. The working hypothesis is advanced that local or systemic stress through the release of epinephrine may result in an increase of a circulating activator of proteolysis and that this in turn may give rise to the release of vasoactive substances,—possibly histamine, serotonin, or a polypeptide.
    Type of Medium: Online Resource
    ISSN: 1540-9538 , 0022-1007
    URL: Article
    DOI: 10.1084/jem.113.2.437
    RVK:
    XA 10000
    Language: English
    Publisher: Rockefeller University Press
    Publication Date: 1961
    detail.hit.zdb_id: 1477240-1
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  • 6
    Online Resource
    Online Resource
    Antihypertensive Action of Neotetrazolium
    SAGE Publications ; 1956
    In:  Experimental Biology and Medicine Vol. 92, No. 4 ( 1956-08-01), p. 752-753
    Details
    In: Experimental Biology and Medicine, SAGE Publications, Vol. 92, No. 4 ( 1956-08-01), p. 752-753
    Type of Medium: Online Resource
    ISSN: 1535-3702 , 1535-3699
    URL: Article
    DOI: 10.3181/00379727-92-22602
    Language: English
    Publisher: SAGE Publications
    Publication Date: 1956
    detail.hit.zdb_id: 2020856-X
    SSG: 12
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  • 7
    Online Resource
    Online Resource
    AN EVALUATION OF THE PROTECTIVE ACTION OF AUTONOMIC BLOCKING AGENTS IN PERIPHERAL CIRCULATORY STRESS
    Ovid Technologies (Wolters Kluwer Health) ; 1954
    In:  Anesthesiology Vol. 15, No. 6 ( 1954-11-01), p. 589-600
    Details
    In: Anesthesiology, Ovid Technologies (Wolters Kluwer Health), Vol. 15, No. 6 ( 1954-11-01), p. 589-600
    Type of Medium: Online Resource
    ISSN: 0003-3022
    URL: Article
    DOI: 10.1097/00000542-195411000-00001
    RVK:
    XA 22600
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 1954
    detail.hit.zdb_id: 2016092-6
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  • 8
    Online Resource
    Online Resource
    Vasoactive properties of plasma protein fractions
    American Physiological Society ; 1964
    In:  American Journal of Physiology-Legacy Content Vol. 206, No. 4 ( 1964-04-01), p. 923-925
    Details
    In: American Journal of Physiology-Legacy Content, American Physiological Society, Vol. 206, No. 4 ( 1964-04-01), p. 923-925
    Abstract: The capacity of plasma to potentiate norepinephrine (NOR)-induced contractions of the rabbit aortic strip can be attributed to the plasma protein fractions, perhaps almost exclusively to their albumin content. Albumin, 0.2–2 mg/15 ml, potentiated a threshold test dose of NOR from minimal to maximal effect. In the presence of albumin 1–2 mg/15 ml, the threshold dose of NOR was decreased about five to ten times. Albumin, 500 mg/15 ml, did not have a greater potentiating effect. Albumin itself had no contracting ability. The blood of the anesthetized rabbit does not contain sufficient NOR to contract the aortic strip; such concentrations of NOR even in the presence of plasma proteins or albumin were ineffective. The data suggest that NOR does not contribute directly to the maintenance of normal vascular tone.
    Type of Medium: Online Resource
    ISSN: 0002-9513
    URL: Article
    DOI: 10.1152/ajplegacy.1964.206.4.923
    RVK:
    WA 15000
    RVK:
    XA 20060
    Language: English
    Publisher: American Physiological Society
    Publication Date: 1964
    detail.hit.zdb_id: 1477334-X
    detail.hit.zdb_id: 2065807-2
    detail.hit.zdb_id: 1477287-5
    detail.hit.zdb_id: 1477308-9
    detail.hit.zdb_id: 1477297-8
    detail.hit.zdb_id: 1477331-4
    detail.hit.zdb_id: 1477300-4
    detail.hit.zdb_id: 1477329-6
    SSG: 12
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  • 9
    Online Resource
    Online Resource
    Influence of Intravascular Pressure on Vascular Response to Epinephrine.
    SAGE Publications ; 1962
    In:  Experimental Biology and Medicine Vol. 111, No. 2 ( 1962-11-01), p. 238-241
    Details
    In: Experimental Biology and Medicine, SAGE Publications, Vol. 111, No. 2 ( 1962-11-01), p. 238-241
    Type of Medium: Online Resource
    ISSN: 1535-3702 , 1535-3699
    URL: Article
    DOI: 10.3181/00379727-111-27753
    Language: English
    Publisher: SAGE Publications
    Publication Date: 1962
    detail.hit.zdb_id: 2020856-X
    SSG: 12
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  • 10
    Online Resource
    Online Resource
    Participation of VEM and VDM Mechanisms in Drum Shock and in Development of ‘Resistance’ to Drum Trauma
    American Physiological Society ; 1950
    In:  American Journal of Physiology-Legacy Content Vol. 164, No. 1 ( 1950-12-31), p. 91-104
    Details
    In: American Journal of Physiology-Legacy Content, American Physiological Society, Vol. 164, No. 1 ( 1950-12-31), p. 91-104
    Type of Medium: Online Resource
    ISSN: 0002-9513
    URL: Article
    DOI: 10.1152/ajplegacy.1950.164.1.91
    RVK:
    WA 15000
    RVK:
    XA 20060
    Language: English
    Publisher: American Physiological Society
    Publication Date: 1950
    detail.hit.zdb_id: 1477334-X
    detail.hit.zdb_id: 2065807-2
    detail.hit.zdb_id: 1477287-5
    detail.hit.zdb_id: 1477308-9
    detail.hit.zdb_id: 1477297-8
    detail.hit.zdb_id: 1477331-4
    detail.hit.zdb_id: 1477300-4
    detail.hit.zdb_id: 1477329-6
    SSG: 12
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