In:
European Journal of Inorganic Chemistry, Wiley, Vol. 2011, No. 36 ( 2011-12), p. 5538-5547
Abstract:
Three ruthenium(II) complexes [Ru(dmp) 2 (dcdppz)] 2+ 1 , [Ru(phen) 2 (dcdppz)] 2+ 2 , and [Ru(dip) 2 (dcdppz)] 2+ 3 were synthesized and characterized. The crystal structure of complex 1 was solved by single‐crystal X‐ray diffraction. This complex crystallizes in the monoclinic system, space group C 2/ c with a = 18.454(3) Å, b = 44.648(7) Å, c = 13.082(2) Å, β = 99.911(3)°, R = 0.0571, and R ω = 0.1501. The DNA‐binding constants were determined to be 1.78 (±0.24) × 10 5 , 2.73 (±0.16) × 10 5 , and 7.55 (±0.16) × 10 5 M –1 for 1 , 2 , and 3 , respectively. The photocleavage of pBR322 DNA by Ru II complexes was studied. The retardation assay of pGL 3 plasmid DNA was investigated. The cytotoxicity of complexes 1 , 2 , and 3 against BEL‐7402, Hela, HepG‐2, and MG‐63 cells was evaluated by the MTT method. Complexes 1 and 3 show higher cytotoxicity than Cisplatin on Hela cells. The apoptosis and cell cycle arrest were investigated, and the antioxidant activities of these complexes were also explored.
Type of Medium:
Online Resource
ISSN:
1434-1948
,
1099-0682
DOI:
10.1002/ejic.v2011.36
DOI:
10.1002/ejic.201100848
Language:
English
Publisher:
Wiley
Publication Date:
2011
detail.hit.zdb_id:
1475009-0
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