In:
The Scientific World Journal, Hindawi Limited, Vol. 2014 ( 2014), p. 1-4
Abstract:
Zinc-enriched yeast (ZnY) and zinc sulfate (ZnSO 4 ) are considered zinc (Zn) supplements currently available. The purpose of the investigation was to compare and evaluate pharmacokinetics and biodistribution of ZnY and ZnSO 4 in rats. ZnY or ZnSO 4 were orally administered to rats at a single dose of 4 mg Zn/kg and Zn levels in plasma and various tissues were determined using inductively coupled plasma-optical emission spectrometry. Maximum plasma concentration values were 3.87 and 2.81 μ g/mL for ZnY and ZnSO 4 , respectively. Both ZnY and ZnSO 4 were slowly eliminated with a half-life of over 7 h and bone had the highest Zn level in all tissues. Compared to ZnSO 4 , the relative bioavailability of ZnY was 138.4%, indicating that ZnY had a significantly higher bioavailability than ZnSO 4 .
Type of Medium:
Online Resource
ISSN:
2356-6140
,
1537-744X
Language:
English
Publisher:
Hindawi Limited
Publication Date:
2014
detail.hit.zdb_id:
2075968-X
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