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  • 1
    Online Resource
    Online Resource
    The effects of streptozotocin-induced diabetes on brucellosis of rats
    Oxford University Press (OUP) ; 2003
    In:  FEMS Immunology & Medical Microbiology Vol. 39, No. 3 ( 2003-12), p. 275-278
    Details
    In: FEMS Immunology & Medical Microbiology, Oxford University Press (OUP), Vol. 39, No. 3 ( 2003-12), p. 275-278
    Type of Medium: Online Resource
    ISSN: 0928-8244 , 1574-695X
    URL: Article
    DOI: 10.1016/S0928-8244(03)00257-8
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2003
    detail.hit.zdb_id: 2693712-8
    detail.hit.zdb_id: 1500464-8
    SSG: 12
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  • 2
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    Clinical Impact of Glucagon-Like Peptide-1 Receptor Analogs on the Complications of Obesity
    S. Karger AG ; 2023
    In:  Obesity Facts Vol. 16, No. 2 ( 2023), p. 149-163
    Details
    In: Obesity Facts, S. Karger AG, Vol. 16, No. 2 ( 2023), p. 149-163
    Abstract: 〈 b 〉 〈 i 〉 Background: 〈 /i 〉 〈 /b 〉 Obesity is a chronic disease associated with increased morbidity and mortality due to its complications. The aims of obesity treatment are primarily to accomplish weight loss, and prevention or treatment of its complications. Lifestyle changes along with behavioral therapy constitute the first-line treatment of obesity followed by pharmacotherapy. Glucagon-like peptide receptor analogs (GLP-1 RAs) are among the approved pharmacotherapy options. Their central effect on suppressing appetite results in considerable weight loss. However, their effect on the complications of obesity has not been very well recognized. This review aims to analyze the effects of GLP-1 RAs on the complications of obesity, as diabetes mellitus, hypertension, nonalcoholic steatohepatitis (NASH), cardiovascular diseases, polycystic ovary syndrome, infertility, obstructive sleep apnea (OSA), osteoarthritis, cancer and central nervous system problems. 〈 b 〉 〈 i 〉 Summary: 〈 /i 〉 〈 /b 〉 Data from preclinical studies and clinical trials have been thoroughly evaluated. Effects regarding the complications as far as the scope of this review have covered can be summarized as blood glucose lowering, blood pressure lowering, resolution of NASH, improving major cardiovascular events, improving fertility and sex hormone levels, and improvement in OSA symptoms and in cognitive scores. Although the mechanisms are not fully elucidated, it is clear that the effects are not solely due to weight loss, but some pleiotropic effects like decreased inflammation, oxidative stress, and fibrosis also play a role in some of the complications. 〈 b 〉 〈 i 〉 Key Messages: 〈 /i 〉 〈 /b 〉 Treating obesity is not only enabling weight loss but ameliorating complications related to obesity. Thus, any antiobesity medication has to have some favorable effects on the complications. As far as the GLP-RA’s analogs are concerned, there seems to be an improvement in many of the complications regardless of the weight loss effect of these medications.
    Type of Medium: Online Resource
    ISSN: 1662-4025 , 1662-4033
    URL: Article
    DOI: 10.1159/000526808
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2023
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  • 3
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    Online Resource
    High prevalence of obesity and diabetes mellitus in Konya, a central Anatolian city in Turkey
    Elsevier BV ; 2005
    In:  Diabetes Research and Clinical Practice Vol. 70, No. 2 ( 2005-11), p. 151-158
    Details
    In: Diabetes Research and Clinical Practice, Elsevier BV, Vol. 70, No. 2 ( 2005-11), p. 151-158
    Type of Medium: Online Resource
    ISSN: 0168-8227
    URL: Article
    DOI: 10.1016/j.diabres.2005.03.030
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2005
    detail.hit.zdb_id: 2004910-9
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  • 4
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    Online Resource
    Criteria for EASO-Collaborating Centres for Obesity Management
    S. Karger AG ; 2011
    In:  Obesity Facts Vol. 4, No. 4 ( 2011), p. 329-333
    Details
    In: Obesity Facts, S. Karger AG, Vol. 4, No. 4 ( 2011), p. 329-333
    Type of Medium: Online Resource
    ISSN: 1662-4033 , 1662-4025
    URL: Article
    DOI: 10.1159/000331236
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2011
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  • 5
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    Interdisciplinary European Guidelines on Metabolic and Bariatric Surgery
    S. Karger AG ; 2013
    In:  Obesity Facts Vol. 6, No. 5 ( 2013), p. 449-468
    Details
    In: Obesity Facts, S. Karger AG, Vol. 6, No. 5 ( 2013), p. 449-468
    Abstract: In 2012, an outstanding expert panel derived from IFSO-EC (International Federation for the Surgery of Obesity - European Chapter) and EASO (European Association for the Study of Obesity), composed by key representatives of both Societies including past and present presidents together with EASO's OMTF (Obesity Management Task Force) chair, agreed to devote the joint Medico-Surgical Workshop of both institutions to the topic of metabolic surgery as a pre-satellite of the 2013 European Congress on Obesity (ECO) to be held in Liverpool given the extraordinarily advancement made specifically in this field during the past years. It was further agreed to revise and update the 2008 Interdisciplinary European Guidelines on Surgery of Severe Obesity produced in cooperation of both Societies by focusing in particular on the evidence gathered in relation to the effects on diabetes during this lustrum and the subsequent changes that have taken place in patient eligibility criteria. The expert panel composition allowed the coverage of key disciplines in the comprehensive management of obesity and obesity-associated diseases, aimed specifically at updating the clinical guidelines to reflect current knowledge, expertise and evidence-based data on metabolic and bariatric surgery.
    Type of Medium: Online Resource
    ISSN: 1662-4025 , 1662-4033
    URL: Article
    DOI: 10.1159/000355480
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2013
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  • 6
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    Online Resource
    How Things Happen
    S. Karger AG ; 2013
    In:  Obesity Facts Vol. 6, No. 5 ( 2013), p. 481-482
    Details
    In: Obesity Facts, S. Karger AG, Vol. 6, No. 5 ( 2013), p. 481-482
    Type of Medium: Online Resource
    ISSN: 1662-4025 , 1662-4033
    URL: Article
    DOI: 10.1159/000356090
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2013
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  • 7
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    Online Resource
    An EASO Position Statement on Multidisciplinary Obesity Management in Adults
    S. Karger AG ; 2014
    In:  Obesity Facts Vol. 7, No. 2 ( 2014), p. 96-101
    Details
    In: Obesity Facts, S. Karger AG, Vol. 7, No. 2 ( 2014), p. 96-101
    Abstract: Obesity has proven to be a gateway to ill health. It has already reached epidemic proportions becoming one of the leading causes of death and disability in Europe and world-wide. Obesity plays a central role in the development of a number of risk factors and chronic diseases like hypertension, dyslipidaemia and type 2 diabetes mellitus inducing cardiovascular morbidity and mortality. Therefore weight management plays a central role in controlling the respective risk factors and their consequences. Obesity is a complex condition of multifactorial origin. Biological but also psychological and social factors interfere to lead to excess body weight and its deleterious outcomes. Obesity management cannot focus any more only on weight (and BMI) reduction. More attention is to be paid to waist circumference (or waist-to-hip ratio, especially in females), the improvement in body composition (measured with body composition tracking systems like BOD POD, dual energy X-ray absorptiometry or bioelectrical impedance analysis) which is focusing on ameliorating or maintaining fat-free mass and decreasing fat mass. Management of co-morbidities, improving quality of life and well-being of obese patients are also included in treatment aims. This statement emphasises the importance of a comprehensive approach to obesity management.
    Type of Medium: Online Resource
    ISSN: 1662-4025 , 1662-4033
    URL: Article
    DOI: 10.1159/000362191
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2014
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  • 8
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    Online Resource
    European Association for the Study of Obesity Position Statement on Medical Nutrition Therapy for the Management of Overweight and Obesity in Adults Developed in Collaboration with the European Federation of the Associations of Dietitians
    S. Karger AG ; 2023
    In:  Obesity Facts Vol. 16, No. 1 ( 2023), p. 11-28
    Details
    In: Obesity Facts, S. Karger AG, Vol. 16, No. 1 ( 2023), p. 11-28
    Abstract: 〈 b 〉 〈 i 〉 Introduction: 〈 /i 〉 〈 /b 〉 Obesity affects nearly 1 in 4 European adults increasing their risk for mortality and physical and psychological morbidity. Obesity is a chronic relapsing disease characterized by abnormal or excessive adiposity with risks to health. Medical nutrition therapy based on the latest scientific evidence should be offered to all Europeans living with obesity as part of obesity treatment interventions. 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 A systematic review was conducted to identify the latest evidence published in the November 2018–March 2021 period and to synthesize them in the European guidelines for medical nutrition therapy in adult obesity. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 Medical nutrition therapy should be administered by trained dietitians as part of a multidisciplinary team and should aim to achieve positive health outcomes, not solely weight changes. A diverse range of nutrition interventions are shown to be effective in the treatment of obesity and its comorbidities, and dietitians should consider all options and deliver personalized interventions. Although caloric restriction-based interventions are effective in promoting weight reduction, long-term adherence to behavioural changes may be better supported via alternative interventions based on eating patterns, food quality, and mindfulness. The Mediterranean diet, vegetarian diets, the Dietary Approaches to Stop Hypertension, portfolio diet, Nordic, and low-carbohydrate diets have all been associated with improvement in metabolic health with or without changes in body weight. In the November 2018–March 2021 period, the latest evidence published focused around intermittent fasting and meal replacements as obesity treatment options. Although the role of meal replacements is further strengthened by the new evidence, for intermittent fasting no evidence of significant advantage over and above continuous energy restriction was found. Pulses, fruit and vegetables, nuts, whole grains, and dairy foods are also important elements in the medical nutrition therapy of adult obesity. 〈 b 〉 〈 i 〉 Discussion: 〈 /i 〉 〈 /b 〉 Any nutrition intervention should be based on a detailed nutritional assessment including an assessment of personal values, preferences, and social determinants of eating habits. Dietitians are expected to design interventions that are flexible and person centred. Approaches that avoid caloric restriction or detailed eating plans (non-dieting approaches) are also recommended for improvement of quality of life and body image perceptions.
    Type of Medium: Online Resource
    ISSN: 1662-4025 , 1662-4033
    URL: Article
    DOI: 10.1159/000528083
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2023
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  • 9
    Online Resource
    Online Resource
    European Guidelines for Obesity Management in Adults
    S. Karger AG ; 2015
    In:  Obesity Facts Vol. 8, No. 6 ( 2015), p. 402-424
    Details
    In: Obesity Facts, S. Karger AG, Vol. 8, No. 6 ( 2015), p. 402-424
    Abstract: Obesity is a chronic metabolic disease characterised by an increase of body fat stores. It is a gateway to ill health, and it has become one of the leading causes of disability and death, affecting not only adults but also children and adolescents worldwide. In clinical practice, the body fatness is estimated by BMI, and the accumulation of intra-abdominal fat (marker for higher metabolic and cardiovascular disease risk) can be assessed by waist circumference. Complex interactions between biological, behavioural, social and environmental factors are involved in regulation of energy balance and fat stores. A comprehensive history, physical examination and laboratory assessment relevant to the patient's obesity should be obtained. Appropriate goals of weight management emphasise realistic weight loss to achieve a reduction in health risks and should include promotion of weight loss, maintenance and prevention of weight regain. Management of co-morbidities and improving quality of life of obese patients are also included in treatment aims. Balanced hypocaloric diets result in clinically meaningful weight loss regardless of which macronutrients they emphasise. Aerobic training is the optimal mode of exercise for reducing fat mass while a programme including resistance training is needed for increasing lean mass in middle-aged and overweight/obese individuals. Cognitive behavioural therapy directly addresses behaviours that require change for successful weight loss and weight loss maintenance. Pharmacotherapy can help patients to maintain compliance and ameliorate obesity-related health risks. Surgery is the most effective treatment for morbid obesity in terms of long-term weight loss. A comprehensive obesity management can only be accomplished by a multidisciplinary obesity management team. We conclude that physicians have a responsibility to recognise obesity as a disease and help obese patients with appropriate prevention and treatment. Treatment should be based on good clinical care, and evidence-based interventions; should focus on realistic goals and lifelong multidisciplinary management.
    Type of Medium: Online Resource
    ISSN: 1662-4025 , 1662-4033
    URL: Article
    DOI: 10.1159/000442721
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2015
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  • 10
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    Online Resource
    Risk Factors Influencing Seroconversion after Inactive SARS-CoV-2 Vaccination in People Living with Obesity
    S. Karger AG ; 2022
    In:  Obesity Facts Vol. 15, No. 5 ( 2022), p. 648-654
    Details
    In: Obesity Facts, S. Karger AG, Vol. 15, No. 5 ( 2022), p. 648-654
    Abstract: 〈 b 〉 〈 i 〉 Introduction: 〈 /i 〉 〈 /b 〉 The aim of this study was to investigate the antibody titers against SARS-CoV-2 spike antigens and the risk factors affecting antibody levels in people living with obesity (PwO) after inactive SARS-CoV-2 vaccine (CoronaVac) administration. 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 169 consecutive patients with obesity who visited the Center for Obesity Management at Istanbul University-Cerrahpaşa, Cerrahpaşa Medical Faculty Hospitals, between May and August 2021, were invited to the study. The nonobese control group was recruited from 191 subjects who visited the Cerrahpaşa Hospitals Vaccination Unit. The study group and the nonobese control group have already received two doses of inactive SARS-CoV-2 vaccine. The SARS-CoV-2 IgG nucleocapsid antibody test was administered to patients and control subjects to discover those who had prior SARS-CoV-2 infection. Forty-one patients who had prior infection and received two doses of vaccine were also included in the study as a subgroup. Blood samples were taken on the 3rd to 4th week after the second vaccination. SARS-CoV-2 IgG antibody titers were determined by quantitative serological methods. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 Antibody titers against SARS-CoV-2 spike antigen of individuals with BMI ≥30.0 kg/m 〈 sup 〉 2 〈 /sup 〉 were significantly lower than those with BMI & #x3c;30 kg/m 〈 sup 〉 2 〈 /sup 〉 ( 〈 i 〉 p 〈 /i 〉 = 0.001) in the study group. Moreover, the antibody titers in people with BMI ≥30.0 kg/m 〈 sup 〉 2 〈 /sup 〉 were significantly lower than in those having a BMI & #x3c;30.0 kg/m 〈 sup 〉 2 〈 /sup 〉 in the subgroup ( 〈 i 〉 p 〈 /i 〉 = 0.03). Age ( 〈 i 〉 p 〈 /i 〉 = 0.03), BMI ( 〈 i 〉 p 〈 /i 〉 = 0.006), and hypertension ( 〈 i 〉 p 〈 /i 〉 = 0.03) were found to be independent risk factors for antibody response in PwO. Women with non-prior SARS-CoV-2 infection showed a significantly higher antibody response then men ( 〈 i 〉 p 〈 /i 〉 = 0.001). 〈 b 〉 〈 i 〉 Conclusion: 〈 /i 〉 〈 /b 〉 SARS-CoV-2-Immunoglobulin G antibody levels against inactive (CoronaVac) vaccine were found to be lower in PwO compared to nonobese individuals. Antibody titers may be measured, and booster doses should be delivered accordingly in PwO for optimal protection.
    Type of Medium: Online Resource
    ISSN: 1662-4025 , 1662-4033
    URL: Article
    DOI: 10.1159/000525555
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2022
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