In:
Current Pharmaceutical Biotechnology, Bentham Science Publishers Ltd., Vol. 25, No. 1 ( 2024-01), p. 93-101
Abstract:
A significant part of blast injury is accompanied by hemorrhagic shock
(BS), while research on its fluid resuscitation strategies have not been reported. Although blood products are usually recommended in most resuscitation cases, they are less available in certain
conditions. To this end, here, we focused on a widely used and more accessible fluid type- crystalloid fluid, in BS treatment. Methods: We conducted studies in rats comparing the therapeutic effects of 3 different crystalloid
solutions at different time points after BS, and explored the underlying mechanisms. Generally, the survival rates gradually dropped along with the time when fluid resuscitation was given. Results: Among different types of solution, the hypertonic saline (HS) group showed the highest
survival rates. The lactated Ringer’s solution (LR) only displayed lifesaving effect at 0.5 h resuscitation time point. Moreover, it is worth noting that the survival rates of the normal saline (NS)
group at all the time points were lower than the non-treatment control. Mechanism study in rats indicated that the therapeutic differences may be caused by varied degrees of pulmonary edema
and inflammatory responses under different crystalloid fluid resuscitation. Conclusion: In conclusion, we assessed the effects and investigated the mechanisms of different
crystalloid fluid resuscitation strategies for BS for the first time, which potentially contributes to the establishment of guidance for crystalloid fluid resuscitation of BS patients.
Type of Medium:
Online Resource
ISSN:
1389-2010
DOI:
10.2174/1389201024666230330100423
Language:
English
Publisher:
Bentham Science Publishers Ltd.
Publication Date:
2024
SSG:
15,3
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