In:
Chemotherapy, S. Karger AG, Vol. 54, No. 3 ( 2008), p. 228-235
Abstract:
〈 i 〉 Background: 〈 /i 〉 To evaluate the efficacy and toxicity of an oxaliplatin, fluorouracil (5-FU), and folinic acid (FOLFOX-6) combination therapy in patients with advanced or recurrent gastric cancer. 〈 i 〉 Methods: 〈 /i 〉 Patients with previously untreated advanced or recurrent gastric cancer received oxaliplatin 100 mg/m 〈 sup 〉 2 〈 /sup 〉 and leucovorin 400 mg/m 〈 sup 〉 2 〈 /sup 〉 (2-hour intravenous infusion) followed by a 5-FU bolus of 400 mg/m 〈 sup 〉 2 〈 /sup 〉 (10-min infusion) and then 5-FU 2,600–3,000 mg/m 〈 sup 〉 2 〈 /sup 〉 (46-hour continuous infusion). The chemotherapy was repeated every 14 days. 〈 i 〉 Results: 〈 /i 〉 Fifty-one patients were enrolled in this study. Of these, 46 were assessable for efficacy, and all patients were assessable for toxicity. Three of 51 patients achieved a complete response, and 18 had partial responses, giving an overall response rate of 41.2%. Stable disease was observed in 11 (21.6%) patients and progressive disease in 14 (27.5%). The median time to progression was 5.4 months, and the median overall survival was 12.1 months. NCI-CTC grade 3/4 hematological toxicities were neutropenia and anemia in 9.8 and 7.8% of the patients, respectively. Grade 3 peripheral neuropathy was recorded in 3 (5.9%) patients. Other NCI-CTC grade 3 or 4 toxicities included diarrhea in 3 patients (5.9%) and vomiting in 5 (9.8%). There were no treatment-related deaths. 〈 i 〉 Conclusions: 〈 /i 〉 This oxaliplatin/5-FU/folinic acid regimen shows good efficacy and an acceptable toxicity profile in advanced or recurrent gastric cancer patients; further clinical trials are warranted.
Type of Medium:
Online Resource
ISSN:
0009-3157
,
1421-9794
Language:
English
Publisher:
S. Karger AG
Publication Date:
2008
detail.hit.zdb_id:
1482111-4
SSG:
15,3
Permalink